Research press release


Nature Communications

Biology: Diet and colon cancer risk in African Americans


今回、Stephen O’Keefeたちは、アフリカ系アメリカ人(20名)とアフリカ農村部の住民(20名)を対象として、大腸がんの発生における食事の重要性に関する一連の調査を行った。その結果、両集団の食事は根本的に異なっており、動物性タンパク質と動物性脂肪の摂取量はアフリカ系アメリカ人の方が2~3倍多く、炭水化物と繊維質の摂取量はアフリカ農村部の住民の方が多いということが分かった。また、大腸内視鏡検査では、アフリカ系アメリカ人に大腸がんバイオマーカーが多く見られた。



A fibre rich, low fat diet may help to reduce colon cancer risk in African Americans, reports a study published in Nature Communications. Colon cancer is the second leading cause of cancer death in western society and African Americans show the highest incidence of the disease in the USA.

Stephen O’Keefe and colleagues performed a series of investigations on the importance of diet in the development of colon cancer in a group of 20 African Americans and 20 rural African participants. They found that diets in both populations were fundamentally different, with animal protein and fat intake 2 to 3 times higher in African Americans, and carbohydrate and fibre intake higher in Africans. Colonoscopy results showed greater incidence of colon cancer biomarkers in African Americans.

These differences were also associated with a profound difference in microbiota in both populations. Africans had higher levels of carbohydrate fermenting and butyrate producing bacteria, and African Americans had higher levels of bile acid metabolising bacteria. There is already extensive evidence suggesting an anti-inflammatory and tumour suppressant role for the products of fibre fermentation (particularly butyrate), and evidence suggesting that some products of bile acid metabolism are carcinogenic. These findings may indicate a possible mechanism for dietary mediation of certain colon cancer risk factors.

The authors then conducted a two-week food exchange between the populations, which had a significant impact on colonic microbiota and associated metabolites, resulting in a reduction in cancer risk biomarkers in African Americans, and an increase in rural Africans. This suggests that a move to a fibre rich, low fat diet may impact the high levels of colon cancer in the African American population, however longitudinal studies are necessary to demonstrate this.

doi: 10.1038/ncomms7342

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