Research press release


Nature Communications

Hair replacement: Connecting the follicle in mice

毛のないマウスに移植された毛包が、筋肉や神経繊維などの周辺組織と結合したことを報告する論文が、今週、Nature Communicationsに掲載される。この研究は、幹細胞から生成した毛包細胞を移植する技術を前進させる可能性がある。



Hair follicles transplanted into a hairless mouse, which form connections with the surrounding tissue including muscle and nerve fibres are reported in a study published in Nature Communications this week. The work could further enhance the ability to transplant hairs generated from stem cells.

Organs such as teeth, salivary glands and hair follicles have been previously engineered. Takashi Tsuji and colleagues previously reported that a hair follicle and its shaft can be regenerated from embryonic follicle stem cells. Using similar starting tissue, and also adult hair follicle-derived stem cells, they now show that the bioengineered hair follicle germs can be transplanted into hairless mice and form functional hair follicles. The hair follicles can connect with the surrounding skin layer, muscles and nerve fibres and in response to a stimulus can stand on end. The transplanted follicles can also undergo normal hair cycling.

The findings further our understanding of hair follicle transplantation.

doi: 10.1038/ncomms1784


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