Research press release


Nature Communications

Epidemiology: Global analysis finds male patients are at higher risk of severe COVID-19

このほど全世界の新型コロナウイルス感染症(COVID-19)症例の300万例以上の解析が行われ、男性患者が集中治療室へ入室する必要が生じる確率は、女性の約3倍に達することが示唆された。また、男性患者の方がCOVID-19による死亡リスクが高いことも判明した。この研究結果について報告する論文が、Nature Communication に掲載される。


今回、Kate Webb、Claire Deakinたちの研究チームは、政府のウェブサイトと既発表文献から得た2020年1月1日〜6月1日の92件の報告書のメタ解析を行い、性別がSARS-CoV-2感染のリスク因子なのかどうか、そしてCOVID-19による死亡率を調べた。今回の解析の対象となったのは、世界46か国と米国44州の合計311万1714件の症例で、それぞれ性別が記録されていた。その結果、このサンプル中の重症急性呼吸器症候群コロナウイルス2(SARS-CoV-2)感染患者の割合に男女差はないことが判明した。しかし、COVID-19のために集中治療室に入室する確率は、男性患者の方が女性患者よりも2.84倍高く、COVID-19によって死亡する確率も男性患者の方が1.39倍高かった。


A global analysis of over three million cases of COVID-19, suggests that male patients with the disease are almost three times more likely to require admission to intensive care than female patients. The study, published in Nature Communications, also finds that male patients have a higher risk of death from COVID-19.

Evidence suggests that there is a bias towards increased disease severity from COVID-19 in male patients. However, this has not been validated in a large-scale analysis of global data.

In a meta-analysis of 92 reports from between 1 January 2020 and 1 June 2020 obtained from government websites and published literature, Kate Webb, Claire Deakin and colleagues investigated whether sex was a risk factor for SARS-CoV-2 infection, and mortality from COVID-19. In total, their analysis included 3,111,714 cases, where sex was recorded, from 46 countries and 44 states in the United States. The authors found that there was no difference in the proportion of male and female patients who were infected with SARS-CoV-2 in their sample. However, male patients were found to have increased odds (2.84 times higher) of being admitted to an intensive care unit as a result of COVID-19. The odds of death from COVID-19 were 1.39 times higher for male patients in their sample than females.

The authors suggest that differences in the immune responses of different sexes are likely to be a factor in the results they observed. However, other biological factors and sex-based co-morbidities may also have an influence. The authors argue that although further studies are needed, these data have important implications for the clinical management of COVID-19 and mitigation strategies.

doi: 10.1038/s41467-020-19741-6

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