Research press release


Nature Communications

Medical research: Repairing wounds with light-activated ‘bio-glue’



今回、Hongwei Ouyangたちの研究グループは、細胞外マトリックス(タンパク質と他の分子のネットワーク)の組成を模倣し、紫外線照射で急速に硬化するゲルを設計した。Ouyangたちは、実験室での予備的な動物実験で、このゲル系でブタの肝臓の創傷を封止できることを示した。彼らは次に、ブタに一連の外科手術を実施し、このヒドロゲルで心臓の創傷を縫合せずに封止できることを実証した。外科手術後、これらのブタのうち3匹を2週間の回復期間にわたって観察したところ、外科手術による異常は見られなかった。

A light-activated adhesive gel that can rapidly seal wounds to arteries and the heart is presented in an article published in Nature Communications. The ‘bio-glue’, demonstrated in a pig model, could have potential applications in surgery in the future. However, additional studies are needed to confirm the safety of the gel for its use in further trials, including those involving humans.

Uncontrolled bleeding following trauma or during surgery is a major cause of death and it is difficult to seal these wounds without sutures (stiches). Gel-based solutions require both strong adhesion to the wet tissue and the strength to resist high blood pressures and the movement of a beating heart. However, very few non-toxic materials meet these criteria.

Hongwei Ouyang and colleagues designed a gel that mimics the composition of the extracellular matrix (a network of proteins and other molecules) and rapidly sets when exposed to ultraviolet light. In preliminary animal experiments in the laboratory, the authors showed that their system was able to seal wounds to pig livers. Following this they performed a set of surgical procedures on pigs and were able to demonstrate that wounds to the heart could be sealed using the hydrogel without the need for sutures. Following the procedure, three of the pigs were monitored for a two-week recovery period and no abnormalities were observed as a result of the surgery.

doi: 10.1038/s41467-019-10004-7

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