Research press release


Nature Communications

Medical research: New potential treatment for heavy menstrual bleeding



今回、Jackie Maybin、Hilary Critchleyたちの研究グループは、子宮内膜がうまく修復されるには低酸素状態になる必要があり、PHD阻害剤という医薬品を月経時のマウスに投与する実験で子宮内膜の修復が促進されることを明らかにした。このPHD阻害剤には、子宮を「騙して」酸素濃度が低いと思わせる作用がある。この実験からは、PHD阻害剤を女性に投与して子宮内膜の修復を加速させ、月経時の出血とそれに関連する症状を緩和し得ることが示唆されているが、こうした結果がヒトでも得られることを確認するため、今後も研究を行う必要がある。

An alternative approach to surgery and hormonal therapy for the treatment of heavy menstrual bleeding is presented in a mouse model this week in Nature Communications. About one in five women will experience this condition at some point in their life, and either undergo surgery, which often precludes later pregnancy, or go under hormonal treatment, which is associated with a wide range of adverse effects. More research is therefore needed to identify alternative treatment options.

In the absence of pregnancy, the lining of the uterus breaks down, causing menstruation. Bleeding persists until the lining of the uterus is successfully repaired. In many women this process comes with severe pain and heavy bleeding, and the risk of developing severe anaemia.

Jackie Maybin, Hilary Critchley and colleagues show that the lining of the uterus needs to experience low levels of oxygen to successfully repair. They show that treatment with a pharmaceutical compound called a PHD inhibitor, which ‘tricks’ the uterus into thinking that oxygen levels are low, promotes repair of the uterus lining in a mouse model of menses. These experiments suggest that PHD inhibitors could be used in women to accelerate repair of the uterus lining and thus reduce bleeding and associated symptoms during menstruation, although further research is needed to confirm these results in humans.

doi: 10.1038/s41467-017-02375-6

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