Volume 552 Number 7683



Grows well in sun and warmth — and shade and cold p.5

Trees and shrubs could be less fussy about the climate than scientists thought. That might be good news as the planet warms.

doi: 10.1038/d41586-017-07841-1


Great mentoring is key for the next generation of scientists p.5

The Nature Awards for Mentoring in Science show that it is crucial to support researchers in leading their groups well.

doi: 10.1038/d41586-017-07840-2


Gene-drive technology needs thorough scrutiny p.6

Scientists must continue to play their part in pointing out the potential environmental dangers.

doi: 10.1038/d41586-017-08214-4



Archaeologists uneasy as Trump shrinks Bears Ears monument lands p.13

Thousands of ancient Native American sites to lose protections.

doi: 10.1038/d41586-017-07794-5


Huge haul of rare pterosaur eggs excites palaeontologists p.14

Embryos found in some fossil eggs suggest that hatchlings struggled to fly.

doi: 10.1038/nature.2017.23049


Bat cave solves mystery of deadly SARS virus — and suggests new outbreak could occur p.15

Chinese scientists find all the genetic building blocks of SARS in a single population of horseshoe bats.

doi: 10.1038/d41586-017-07766-9


Scientists want in on humanity's next big space station p.16

Space agencies are planning a Deep Space Gateway to orbit the Moon.

doi: 10.1038/d41586-017-07869-3


Hundreds of German universities set to lose access to Elsevier journals p.17

Negotiations to reduce journal prices and promote open access are progressing slowly.

doi: 10.1038/d41586-017-07817-1

News Features


The labs that forge distant planets here on Earth p.20


doi: 10.1038/d41586-017-07844-y

News & Views


Nanotechnology: DNA self-assembly scaled up p.34


doi: 10.1038/d41586-017-07690-y


Palaeontology: A tip of the hat to evolutionary change p.35


doi: 10.1038/d41586-017-07440-0


Planetary science: A steamy proposal for Martian clays p.37


doi: 10.1038/d41586-017-07661-3


Parkinson's disease: Vivid views of the PINK1 protein p.38


doi: 10.1038/d41586-017-07691-x


Computational material science: Two-dimensional tellurium p.40


doi: 10.1038/d41586-017-07159-y


Cancer immunotherapy: The dark side of PD-1 receptor inhibition p.41


doi: 10.1038/nature24759


In retrospect: Quantum-teleportation experiments turn 20 p.42


doi: 10.1038/d41586-017-07689-5



Greater future global warming inferred from Earth’s recent energy budget p.45

Models show that several aspects of Earth’s top-of-atmosphere energy budget and the magnitude of projected global warming are correlated, enabling us to infer that future warming has been underestimated.

doi: 10.1038/nature24672


Structure of PINK1 in complex with its substrate ubiquitin p.51

Stabilization of a transient protein kinase–substrate complex using a nanobody provides molecular details about how the Parkinson’s disease-linked protein kinase PINK1 phosphorylates ubiquitin, and suggests new pharmacological strategies.

doi: 10.1038/nature24645


A transfer-RNA-derived small RNA regulates ribosome biogenesis p.57

A 22-nucleotide fragment of a transfer RNA regulates translation by binding to the mRNA of a ribosomal protein and increasing its expression, and downregulation of the fragment in patient-derived liver tumour cells reduces tumour growth in mice.

doi: 10.1038/nature25005



Direct detection of a break in the teraelectronvolt cosmic-ray spectrum of electrons and positrons p.63

A direct measurement of cosmic-ray electrons and positrons with unprecedentedly high energy resolution reveals a spectral break at about 0.9 teraelectronvolts, confirming the evidence found by previous indirect measurements.

doi: 10.1038/nature24475


Fractal assembly of micrometre-scale DNA origami arrays with arbitrary patterns p.67

Simple assembly rules applied recursively in a multistage assembly process enable the creation of DNA origami arrays with sizes of up to 0.5 square micrometres and with arbitrary patterns.

doi: 10.1038/nature24655


Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components p.72

DNA bricks with binding domains of 13 nucleotides instead of the typical 8 make it possible to self-assemble gigadalton-scale, three-dimensional nanostructures consisting of tens of thousands of unique components.

doi: 10.1038/nature24648


Gigadalton-scale shape-programmable DNA assemblies p.78

By using DNA sequence information to encode the shapes of DNA origami building blocks, shape-programmable assemblies can be created, with sizes and complexities similar to those of viruses.

doi: 10.1038/nature24651


Biotechnological mass production of DNA origami p.84

All necessary strands for DNA origami can be created in a single scalable process by using bacteriophages to generate single-stranded precursor DNA containing the target sequences interleaved with self-excising DNA enzymes.

doi: 10.1038/nature24650


Primordial clays on Mars formed beneath a steam or supercritical atmosphere p.88

Many Martian clays formed when Mars’ primary crust reacted with a water/carbon dioxide steam or supercritical atmosphere and subsequent impacts and volcanism caused the distribution of clay exposures seen today.

doi: 10.1038/nature24657


Reconciling taxon senescence with the Red Queen’s hypothesis p.92

Focusing attention on the expansion of taxa, rather than their survival, resolves the apparent contradiction between seemingly deterministic patterns of waxing and waning of taxa over time and the randomness of extinction implied by the Red Queen’s hypothesis.

doi: 10.1038/nature24656


Genetic diversity of the African malaria vector Anopheles gambiae p.96

Genome sequencing analyses from 765 specimens of Anopheles gambiae and Anopheles coluzzii from 15 locations across Africa characterize patterns of gene flow and variations in population size, and provide a resource for studying the evolution of natural malaria vector populations.

doi: 10.1038/nature24995


Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors p.101

Proteins expressed on the surfaces of erythrocytes infected with Plasmodium falciparum help the parasite to evade the host immune system by acting as ligands for immune inhibitory receptors and thereby downregulating the immune response.

doi: 10.1038/nature24994


Maternal age generates phenotypic variation in Caenorhabditis elegans p.106

Maternal age is found to be a major source of phenotypic variation in isogenic C. elegans populations living in a controlled environment, with the progeny of young mothers impaired for multiple fitness traits.

doi: 10.1038/nature25012


IL-11 is a crucial determinant of cardiovascular fibrosis p.110

Fibroblast-specific IL-11 expression causes heart and kidney fibrosis and organ failure, whereas IL-11 inhibition prevents fibroblast activation and organ fibrosis, indicating that IL-11 inhibition is a potential therapeutic strategy to treat fibrotic diseases.

doi: 10.1038/nature24676


Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth p.116

The inactivation of DNA mismatch repair in cancer cells produces dynamic mutational profiles and generates neoantigens, which result in improved immune surveillance against these cells.

doi: 10.1038/nature24673


PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis p.121

Loss of the PD-1 receptor promotes the development of T cell non-Hodgkin lymphomas by modulating oncogenic signalling pathways, and blocking these pathways reduces tumourigenesis.

doi: 10.1038/nature24649


Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control p.126

The methyltransferase METTL3 promotes the leukaemic state in acute myeloid leukaemia (AML) by catalysing the m6A RNA modification through its recruitment on the transcription start sites of AML-associated genes.

doi: 10.1038/nature24678


Genetically programmed chiral organoborane synthesis p.132

A genetically encoded platform can produce chiral organoboranes in bacteria with high turnover, enantioselectivity and chemoselectivity, and can be tuned and configured through DNA manipulation.

doi: 10.1038/nature24996

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