Research press release


Nature Medicine

Inhibition present in absences


脳のてんかん性活動は、抑制性活動が減少し、神経の興奮が亢進した結果起こると一般に考えられている。D Copeたちは、てんかん発作の一種の欠神発作にあたるマウスとラットの発作(通常は、動きが止まり、「宙を見つめる」のが特徴)で、実際には抑制性活動が増加していることを明らかにした。



An unexpected role of inhibitory activity in promoting epilepsy is reported in a study in this week's Nature Medicine. The work points to new potential targets for the treatment of certain types of seizures.

Epileptic activity in the brain is commonly believed to be the result of reduced inhibitory activity and increased neuronal excitation. David Cope and his colleagues show that inhibitory activity is actually increased in mouse and rat forms of epilepsy known as absence seizures ― usually characterized by a lack of movement and sufferers 'staring into space'.

The team found that the increased inhibition is due to a reduction in the uptake of GABA ― the main inhibitory neurotransmitter in the nervous system. The team also found that the selective activation of GABA receptors was sufficient to elicit absence seizures in mice and rats.

These results disclose an unexpected mechanism that may have importance in human epilepsy and point to novel potential targets for the treatment of absence seizures.

doi: 10.1038/nm.2058

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