Research press release


Nature Cell Biology

Spreading brain cancer



X Breakefieldたちは、原発巣のグリオブラストーマ細胞が、血管増殖、細胞の増殖や移動、それに免疫系の回避のような、がんの広がりを促進する機能をもつ遺伝物質とタンパク質を含むマイクロベシクルを分泌していることを報告している。そして、グリオーマに関連している2つの特定の分子、EGFRvIIIとmiRNA-21がマイクロベシクル内に存在し、これらが脳腫瘍患者の血液中で検出可能であることを見いだした。


A simple blood test could be used to diagnose brain cancer, suggests a study published online this week in Nature Cell Biology. This easy procedure could be used as an alternative to the invasive methods currently used to diagnose one of the most aggressive cancers known.

Glioblastomas are highly malignant brain tumours with poor prognosis. Tumour cells release small membrane sacs called microvesicles or exosomes that contain substances capable of altering surrounding tissue. These vesicles can fuse with neighbouring cells and transfer their content leading to the progression of the tumour.

Xandra Breakefield and colleagues report that primary glioblastoma cells release microvesicles containing genetic material and proteins that are involved in cancer-promoting functions. These include growth of blood vessels, cell growth and migration, and evasion of the immune system. The team noted that two specific molecules associated with gliomas, EGFRvIII and miRNA-21, were present in the microvesicles and could be detected in the blood of patients with brain tumours.

This suggests that a simple blood test could be used to identify the presence of these molecules and may be useful as a non-invasive cancer diagnostic.

doi: 10.1038/ncb1800


メールマガジンリストの「Nature 関連誌今週のハイライト」にチェックをいれていただきますと、毎週各ジャーナルからの最新の「注目のハイライト」をまとめて皆様にお届けいたします。