Research press release


Nature Cell Biology

The ‘aggressive’ prostate compartment


M Shenたちは、前立腺がんのマウスモデルを使って、前立腺中の異なるタイプの細胞を起源とする腫瘍は、それぞれ異なる分子シグネチャーをもつようになることを明らかにしている。この分析から、前立腺の管腔細胞から生じた腫瘍は基底細胞から生じたものよりも浸潤性が高いという結果が得られた。基底細胞に由来する腫瘍が腫瘍促進因子の働きによって管腔型腫瘍に似るようになった場合でも、これと同様の結果が見られた。


Tumours that develop in certain cells in the prostate are more aggressive than tumours originating in others, reports work published this week in Nature Cell Biology. The research suggests that tumours that originated in the luminal compartment of the prostate are generally associated with poor patient prognosis.

Michael Shen and colleagues use a mouse model of prostate cancer to show that tumours originating in different types of cells in the prostate give rise to tumours with distinctive molecular signatures. The analysis helped them conclude that tumours arising in the luminal compartment of the prostate are more aggressive than tumours originating in the basal compartment. This is the case even when tumour-promoting factors cause basal tumours to resemble luminal tumours.

The authors also used genetic tracing of cells in mouse prostate to demonstrate the plasticity of basal cell types during prostate regeneration and adult tissue homeostasis. This finding may prove important, as a subset of basal cells seem able to switch to a luminal fate if required.

doi: 10.1038/ncb2697


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