Colorectal cancer (CRC) is a major cause of cancer-related death. To decrease the incidence of CRC, it is recommended that neoplastic lesions (such as adenomas) be resected during colonoscopy1,2. A large cohort study conducted in the United States with 88,902 participants showed a roughly 70% reduction of death from CRC after colonoscopy screening3. However, the quality of the colonoscopy is important; adenoma detection rates (ADRs) during colonoscopy are inversely associated with the incidence of interval CRC (defined as cancer diagnosed between screening and post-screening surveillance examinations) and with CRC-related mortality4,5. However, many adenomas are missed during routine colonoscopy6, and ADR is significantly influenced by inter-endoscopist variability4, which is a major barrier to the standardization of high-quality colonoscopy. Computer-aided detection (CADe) systems powered by artificial intelligence could address this problem7. By indicating the presence and location of polyps in real time during colonoscopies, CADe can function as a second observer, potentially drawing the endoscopist’s attention to polyps that are displayed on the monitor but may be overlooked by the endoscopist.