US Republican idea for tax on carbon makes climate sense p.271

A conservative solution to global warming.

doi: 10.1038/542271b

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Steps to help Turkey build a future on research p.271

The Turkish government must stop university dismissals and commit itself to creating a welcoming research environment if its grand plans for science are to succeed.

doi: 10.1038/542271a

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The dark side of social media p.272

Psychologists find that Internet trolls seem impervious to any efforts to change their behaviour.

doi: 10.1038/542272a

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Three sites where NASA might retrieve its first Mars rock p.279

Agency narrows possible targets for the first-ever sample return from the red planet.

doi: 10.1038/nature.2017.21470

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'Riskiest ideas' win $50 million from Chan Zuckerberg Biohub p.280

Initiative's first grants will fund a medley of wild ideas from top San Francisco Bay Area biologists, engineers and programmers.

doi: 10.1038/nature.2017.21440

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Long-awaited mathematics proof could help scan Earth's innards p.281

Proposed solution to geometry puzzle allows an object’s structure to be determined from limited information.

doi: 10.1038/nature.2017.21439

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World’s largest wind-mapping project spins up in Portugal p.282

International team seeks better picture of wind as it moves over rugged terrain.

doi: 10.1038/542282a

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Heavyweight funders back central site for life-sciences preprints p.283

Coalition of scientists and research agencies argue for a one-stop shop server.

doi: 10.1038/nature.2017.21466

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Elusive triangulene created by moving atoms one at a time p.284

Unstable molecule couldn’t be made through conventional synthesis, so IBM researchers carried out molecular surgery using a microscope tip.

doi: 10.1038/nature.2017.21462

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News Features


The Turkish paradox: Can scientists thrive in a state of emergency? p.286


doi: 10.1038/542286a

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News & Views


Palaeoclimate science: Pulsating ice sheet p.298


doi: 10.1038/542298a

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Physiology: An atypical switch for metabolism and ageing p.299


doi: 10.1038/nature21500

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Genomics: Keen insights from quinoa p.300


doi: 10.1038/nature21495

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Physiology: Gut feeling for food choice p.302


doi: 10.1038/nature21499

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Environmental science: Oceans lose oxygen p.303


doi: 10.1038/542303a

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Evolution: Catastrophe triggers diversification p.304


doi: 10.1038/nature21494

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The genome of Chenopodium quinoa OPEN p.307

Constructing a reference genome for quinoa (Chenopodium quinoa) allows for genetic diversity during the evolution of sub-genomes in quinoa to be characterized and markers that may be used to develop sweet commercial varieties are identified.

doi: 10.1038/nature21370

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Identity and dynamics of mammary stem cells during branching morphogenesis p.313

The formation of the branched epithelial network of the mouse mammary gland during puberty is driven by a heterogeneous population of stem cells at the terminal end buds of the epithelium.

doi: 10.1038/nature21046

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Cryo-EM structure of a human spliceosome activated for step 2 of splicing p.318

The cryo-EM structure of the splicing intermediate known as the C* complex from human.

doi: 10.1038/nature21079

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Photovoltage field-effect transistors p.324

A photovoltage field-effect transistor is demonstrated that is very sensitive to infrared light and has high gain.

doi: 10.1038/nature21050

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Stable colloids in molten inorganic salts p.328

A class of colloids is reported in which inorganic solute particles—such as metals and semiconductors—are dispersed in molten inorganic salts.

doi: 10.1038/nature21041

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Heinrich events triggered by ocean forcing and modulated by isostatic adjustment p.332

Heinrich events — episodes of massive iceberg discharge from the Laurentide Ice Sheet into the North Atlantic Ocean — are triggered by the incursion of warm ocean waters destabilizing the calving front.

doi: 10.1038/nature21069

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Decline in global oceanic oxygen content during the past five decades p.335

The oxygen content of the global ocean has decreased by more than two per cent over the past five decades, with large variations found in different ocean basins and at different ocean depths.

doi: 10.1038/nature21399

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Primordial helium entrained by the hottest mantle plumes p.340

Analysis of helium isotope ratios in volcanic hotspot lavas suggests that hotter, more buoyant plumes upwelling from the deep mantle entrain high-3He/4He material, unlike cooler, less buoyant plumes, implying the existence of a dense, relatively undisturbed primordial reservoir in the deep mantle.

doi: 10.1038/nature21023

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Mega-evolutionary dynamics of the adaptive radiation of birds p.344

A study of more than 2,000 bird species shows that diversity in bill shape expands towards extreme morphologies early in avian evolution in a series of major jumps, before switching to a second phase in which bills repeatedly evolve similar shapes by subdividing increasingly tight regions of already occupied niche space.

doi: 10.1038/nature21074

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Early brain development in infants at high risk for autism spectrum disorder p.348

Surface area expansion from 6–12 months precedes brain overgrowth in high risk infants diagnosed with autism at 24 months and cortical features in the first year predict individual diagnostic outcomes.

doi: 10.1038/nature21369

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Single-cell spatial reconstruction reveals global division of labour in the mammalian liver p.352

Single-molecule fluorescence in situ hybridization is performed to identify several landmark genes in the liver and their level of expression in single-cell RNA sequencing is used to spatially reconstruct the zonation of all liver genes.

doi: 10.1038/nature21065

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EPRS is a critical mTORC1–S6K1 effector that influences adiposity in mice p.357

Glutamyl-prolyl tRNA synthetase (EPRS) is a downstream effector of the mTORC1–S6K1 signalling axis and contributes to adiposity and ageing in mice.

doi: 10.1038/nature21380

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Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer p.362

Depletion of Smarcb1 activates the Myc network of signalling cascades, increasing protein metabolism and activation of survival pathways allowing highly aggressive Kras-independent pancreatic cancer cells to develop.

doi: 10.1038/nature21064

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C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress p.367

Adult neurons from Caenorhabditis elegans can extrude large membrane-surrounded vesicles, known as exophers, containing protein aggregates and dysfunctional organelles that threaten neuronal homeostasis.

doi: 10.1038/nature21362

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MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion p.372

Crystal structures of engineered human MFN1 in different stages of GTP hydrolysis provide insights into the GTP-induced conformational changes that promote MFN1 dimerization to bring about mitochondrial fusion.

doi: 10.1038/nature21077

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Structure of a spliceosome remodelled for exon ligation p.377

The cryo-electron microscopy structure of a yeast spliceosome stalled before mature RNA formation provides insight into the mechanism of exon ligation.

doi: 10.1038/nature21078

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