Volume 537 Number 7619



The historic truth about science fiction from H. G. Wells to Star Trek p.137

Science fiction fights the past as much as it faces the future.

doi: 10.1038/537137b


Macchiarini scandal is a valuable lesson for the Karolinska Institute p.137

Procedures have rightly been tightened in response to the controversy surrounding surgeon Paolo Macchiarini — but the institute must take care not to restrict its science.

doi: 10.1038/537137a


Announcement: Where are the data? p.138

doi: 10.1038/537138a



Mars contamination fear could divert Curiosity rover p.145

NASA must avoid spreading Earth microbes to suspected water in hillside streaks.

doi: 10.1038/537145a


London super-lab opens under cloud of Brexit p.147

Research begins at the unabashedly international Francis Crick Institute.

doi: 10.1038/nature.2016.20530


Boom in unproven cell therapies intensifies regulatory debate p.148

Controversial US guidelines attempt to rein in rogue stem-cell clinics.

doi: 10.1038/537148a


Venerable brain-cancer cell line faces identity crisis p.149

Samples of the cell line do not match its 50-year-old source ― but how the mix-up occurred is a mystery.

doi: 10.1038/nature.2016.20515


US science agencies face budget limbo p.149

Likelihood of stopgap spending measure grows.

doi: 10.1038/537149a

News Features


How to raise a genius: lessons from a 45-year study of super-smart children p.152


doi: 10.1038/537152a


The new breed of cutting-edge catalysts p.156


doi: 10.1038/537156a

News & Views


Drug discovery: Designing the ideal opioid p.170


doi: 10.1038/nature19424


Nanoscience: Slippery when narrow p.171


doi: 10.1038/537171a


Conservation: Mapping the terrestrial human footprint p.172


doi: 10.1038/537172a


Astrophysics: Violent emissions of newborn stars p.174


doi: 10.1038/537174a


Structural biology: Catalytic spliceosome captured p.175


doi: 10.1038/nature19422


Evolutionary biology: Fin to limb within our grasp p.176


doi: 10.1038/nature19425



Photocontrol of fluid slugs in liquid crystal polymer microactuators p.179

A light-actuated liquid crystal polymer material system precisely manipulates liquid drops through capillary forces, and can be formed into a variety of shapes.

doi: 10.1038/nature19344


Structure-based discovery of opioid analgesics with reduced side effects p.185

Computational docking to the the μ-opioid-receptor identifies PZM21, a novel selective biased agonist that generates substantial affective analgesia in mice without altering respiration or inducing drug reinforcement.

doi: 10.1038/nature19112

構造生物学:電位依存性カルシウムチャネルCav1.1の3.6 Å分解能での構造

Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution p.191

The cryo-electron microscopy structure of the rabbit voltage-gated calcium channel Cav1.1 complex at a nominal resolution of 3.6 ångströms.

doi: 10.1038/nature19321


Cryo-EM structure of the spliceosome immediately after branching p.197

Cryo-EM reveals the configuration of substrate pre-mRNA within the active spliceosome and suggests how remodelling occurs prior to exon ligation.

doi: 10.1038/nature19316


Structural basis for the antifolding activity of a molecular chaperone p.202

The solution structure of SecB, a molecular chaperone that exhibits strong antifolding activity, in complex with alkaline phosphatase and maltose-binding protein captured in their unfolded states.

doi: 10.1038/nature18965



Compression and ablation of the photo-irradiated molecular cloud the Orion Bar p.207

One-arcsecond-resolution millimetre-wave images enable the surface of the Orion Bar molecular cloud to be resolved, revealing a fragmented ridge of high-density substructures, photoablative gas flows and instabilities that suggest that the cloud edge has been compressed by a high-pressure wave expanding into the molecular cloud, in contrast to predictions from static equilibrium models.

doi: 10.1038/nature18957


Massive radius-dependent flow slippage in carbon nanotubes p.210

The pressure-driven flow rate through individual carbon nanotubes is precisely determined from the hydrodynamics of emerging water jets, revealing unexpectedly large and radius-dependent surface slippage.

doi: 10.1038/nature19315


Oxidative diversification of amino acids and peptides by small-molecule iron catalysis p.214

Two small-molecule iron catalysts are shown to be capable of facilitating the targeted C–H oxidative modification of amino acids and peptides with preservation of α-centre chirality (a challenging synthesis), producing a diverse range of amino acids and peptides.

doi: 10.1038/nature18941


A progressively wetter climate in southern East Africa over the past 1.3 million years p.220

A 1.3-million-year-long climate history from the Lake Malawi basin in eastern Africa displays a trend towards progressively wetter conditions superimposed on strong 100,000-year eccentricity cycles of temperature and rainfall since the Mid-Pleistocene Transition around 900,000 years ago.

doi: 10.1038/nature19065


Digits and fin rays share common developmental histories p.225

Hoxa- and Hoxd-deficient zebrafish generated using Crispr/Cas with fate mapping have reduced fin rays and increased endochondral elements, establishing homology between the developmental programs that create fin rays and the wrists and digits of mammals.

doi: 10.1038/nature19322


Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness p.229

A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious in vivo, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.

doi: 10.1038/nature19339


Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system p.234

Hypoxia in germinal centres regulates B cell class switching via its effects on mTOR complex 1 and activation-induced cytosine deaminase activity.

doi: 10.1038/nature19334

免疫学:長鎖非コードRNA Morrbidは、Bimと短命の骨髄性細胞の寿命を調節している

The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan p.239

The long non-coding RNA Morrbid controls myeloid cell lifespan and regulates apoptosis by repressing the adjacent pro-apoptotic Bcl2l11 gene in cis.

doi: 10.1038/nature19346


PionX sites mark the X chromosome for dosage compensation p.244

Recognition of the X chromosome by the dosage compensation complex in Drosophila relies on the sequence and shape of PionX sites.

doi: 10.1038/nature19338


Insights from biochemical reconstitution into the architecture of human kinetochores p.249

Biochemical reconstitution of a synthetic human kinetochore with 21 protein subunits and centromeric nucleosomal DNA unveils fundamental principles of kinetochore organization and function.

doi: 10.1038/nature19333

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