Volume 511 Number 7511



Fishy business p.507

Delays in approving genetically engineered salmon may be a taste of worse to come.

doi: 10.1038/511507b


Safety doesn’t happen by accident p.507

To create a strong biosafety culture, information on mishaps involving deadly pathogens must be reported and shared fully and transparently.

doi: 10.1038/511507a



Biosafety controls come under fire p.515

Experts call for a stronger safety culture at secure sites after incidents involving anthrax and flu in a US laboratory.

doi: 10.1038/511515a


Project drills deep into coming quake p.516

Sensors in borehole at New Zealand seismic fault will peek under the surface of impending rupture.

doi: 10.1038/511516a


Contamination hits cell work p.518

Mycoplasma infestations are widespread and costing laboratories millions of dollars in lost research.

doi: 10.1038/511518a


FDA debates trial-data secrecy p.519

US drug regulator weighs up merits of disclosing preliminary results.

doi: 10.1038/511519a


Ebola treatments caught in limbo p.520

Logistics and lack of funds keep experimental drugs and vaccines from being used in Africa outbreak.

doi: 10.1038/511520a

News Features


Dam removals: Rivers on the run p.521


doi: 10.1038/511521a


Cancer biomarkers: Written in blood p.524


doi: 10.1038/511524a

News & Views


Palaeoclimate science: Causes and effects of Antarctic ice p.536


doi: 10.1038/511536a


HIV: The mixed blessing of interferon p.537


doi: 10.1038/nature13517


Quantum physics: The path most travelled p.538


doi: 10.1038/511538a


Epigenetics: Cellular memory erased in human embryos p.540


doi: 10.1038/nature13648


Malaria: Protein-export pathway illuminated p.541


doi: 10.1038/nature13646



Comprehensive molecular profiling of lung adenocarcinoma OPEN p.543

An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.

doi: 10.1038/nature13385


Topoisomerase II mediates meiotic crossover interference p.551

Topoisomerase II mediates meiotic crossover interference by adjusting the protein/DNA meshwork of chromosome axes.

doi: 10.1038/nature13442

構造生物学:クラスC GPCRである代謝型グルタミン酸受容体5の膜貫通ドメインの構造

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain p.557

An X-ray structure is presented for metabotropic glutamate receptor 5, a class C G-protein-coupled glutamate receptor linked to fragile X syndrome and neurological disorders; this study provides insights into the protein’s mechanism of action.

doi: 10.1038/nature13396



Velocity anti-correlation of diametrically opposed galaxy satellites in the low-redshift Universe p.563

Measurements of the velocities of pairs of diametrically opposed satellite galaxies of host galaxies in the local Universe show that satellite pairs out to a distance of 150 kiloparsecs from their hosts are anti-correlated in their velocities and that galaxies in the larger-scale environment are strongly clumped along the axis joining the inner satellite pair.

doi: 10.1038/nature13481


Misaligned protoplanetary disks in a young binary star system p.567

Observations show that one or both of the protoplanetary disks in the young binary system HK Tauri are significantly inclined to the binary orbital plane, demonstrating that the necessary conditions exist for the misalignment-driven mechanisms thought to produce the unusual orbits of some extrasolar planets.

doi: 10.1038/nature13521


Mapping the optimal route between two quantum states p.570

Reconstruction of the quantum trajectories of a superconducting circuit that evolves under the competing influences of continuous weak measurement and Rabi drive makes it possible to deduce the most probable path through quantum state space.

doi: 10.1038/nature13559


Antarctic glaciation caused ocean circulation changes at the Eocene–Oligocene transition p.574

A climate model is used to show that the growth of the Antarctic ice sheet at about 34 Myr ago drove changes in ocean circulation, but the opening of ocean gateways had relatively little impact.

doi: 10.1038/nature13597


Widespread mixing and burial of Earth’s Hadean crust by asteroid impacts p.578

A new bombardment model of the early Earth, calibrated with existing lunar and terrestrial data, shows that the Earth’s surface would have been widely reprocessed by impacts through mixing and burial by impact-generated melt; the model may also explain the age distribution of ancient zircons and the absence of early terrestrial rocks.

doi: 10.1038/nature13539


Seasonal not annual rainfall determines grassland biomass response to carbon dioxide p.583

Large annual variation in the stimulation of above-ground biomass by elevated carbon dioxide in a mixed C3/C4 temperate grassland can be predicted accurately using seasonal rainfall totals.

doi: 10.1038/nature13281


PTEX is an essential nexus for protein export in malaria parasites p.587

This paper demonstrates that a protein complex known as PTEX translocates all malaria parasite proteins destined for export into the cytosol of their host red blood cell.

doi: 10.1038/nature13555


PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes p.592

Plasmodium parasites, the causative agent of malaria, infect and remodel red blood cells by exporting hundreds of proteins into the red blood cell cytosol, a topological conundrum given that the parasite resides in a compartment known as the parasitophorous vacuole; here a dihydrofolate-reductase-based destabilization domain approach is used to inactivate HSP101, part of the Plasmodium translocon of exported proteins, and to demonstrate that it is required for the secretion of all classes of exported Plasmodium proteins.

doi: 10.1038/nature13574


Equalizing excitation–inhibition ratios across visual cortical neurons p.596

Different amounts of excitation received by different pyramidal cells of primary visual cortex are matched by proportional amounts of inhibition.

doi: 10.1038/nature13321


Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression p.601

The timing of type I interferon signalling determines the disease course of SIV infection.

doi: 10.1038/nature13554


The DNA methylation landscape of human early embryos p.606

Base-resolution maps of DNA methylation in human gametes and early embryos offer novel insights into human methylation dynamics and the functional relationship between DNA methylation and gene expression.

doi: 10.1038/nature13544


DNA methylation dynamics of the human preimplantation embryo p.611

Genome-scale DNA methylation maps over early human embryogenesis and embryonic stem cell derivation provide insights into shared and unique modes of regulation when compared to the mouse model, including relationships to gene expression, transposable element activity, and maternal-specific methylation.

doi: 10.1038/nature13581


Targeting transcription regulation in cancer with a covalent CDK7 inhibitor p.616

Here, a covalent inhibitor targeting cyclin-dependent kinase 7 (CDK7) demonstrates in vitro and in vivo efficacy against T-cell acute lymphoblastic leukaemia by downregulating oncogenic transcriptional programs.

doi: 10.1038/nature13393

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