Volume 548 Number 7668



Magnetic antiparticle expands strange field of swirling science p.371

Antiskyrmion offers promise for superfast spintronic computers.

doi: 10.1038/548371b


Head injuries in sport must be taken more seriously p.371

Sports organizations are only starting to understand the harm that can be inflicted by high-contact activities. Science must play its part in highlighting the problem and in aiding diagnosis.

doi: 10.1038/548371a



How machine learning could help to improve climate forecasts p.379

Mixing artificial intelligence with climate science helps researchers to identify previously unknown atmospheric processes and rank climate models.

doi: 10.1038/548379a


Supernova’s messy birth casts doubt on reliability of astronomical yardstick p.380

Brightness of exploding stars may vary more than researchers realized.

doi: 10.1038/nature.2017.22066


Ecologists protest Australia’s plans to cut funding for environment-monitoring network p.381

Scientists say the move will reduce the country’s capacity to predict future ecosystem changes.

doi: 10.1038/nature.2017.22453


Mysteries of turbulence unravelled p.382

Simulations follow how swirls in a fluid transfer and dissipate energy.

doi: 10.1038/nature.2017.22474


Theft of South African relics riles researchers p.383

Efforts to relocate artefacts to sites of origin could stall after gold robbery at national park.

doi: 10.1038/nature.2017.22479

News Features


Creeping earth could hold secret to deadly landslides p.384


doi: 10.1038/548384a

News & Views


Neurobiology: Diversity reaches the stars p.396


doi: 10.1038/548396a


Gravitational waves: History of black holes revealed by their spin p.397


doi: 10.1038/548397a


Biotechnology: At the heart of gene edits in human embryos p.398

今回、遺伝子編集技術CRISPR–Casをin vitroで育てられたヒト胚に用いて、疾患関連変異が修正された。編集した構成要素を受精時に導入すると、修復効率が向上した。

doi: 10.1038/nature23533


Materials science: Magnetic molecules back in the race p.400


doi: 10.1038/548400a


Genetics: Role of mutation in fly-wing evolution p.401


doi: 10.1038/nature23536


Atmospheric science: Ancient ice and the global methane cycle p.403


doi: 10.1038/548403a


Global health: Probiotic prevents infections in newborns p.404


doi: 10.1038/nature23540



A randomized synbiotic trial to prevent sepsis among infants in rural India p.407

A synbiotic preparation of Lactobacillus plantarum and fructooligosaccharide was found to significantly reduce sepsis and infections of the lower respiratory tract in a trial involving newborns from rural India.

doi: 10.1038/nature23480


Correction of a pathogenic gene mutation in human embryos p.413

CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.

doi: 10.1038/nature23305


The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis p.420

An atomic model of the primed pre-fusion SNARE–complexin–synaptotagmin-1 complex in neuronal exocytosis accounting for vesicle priming and cooperation in synchronizing and activating evoked release on the sub-millisecond timescale.

doi: 10.1038/nature23484



Distinguishing spin-aligned and isotropic black hole populations with gravitational waves p.426

The spins of the black holes involved in each of the four mergers that have been detected in gravitational waves so far were either small or not aligned with the binary orbit.

doi: 10.1038/nature23453


Large turbulent reservoirs of cold molecular gas around high-redshift starburst galaxies p.430

Large haloes of diffuse molecular gas discovered around high-redshift starburst galaxies show that galactic feedback, coupled to turbulence and gravity, extends the starburst phase instead of quenching it.

doi: 10.1038/nature23298


Epitaxy of advanced nanowire quantum devices p.434

A finely tuned growth strategy to generate nanowire networks that fulfil all the prerequisites for braiding may lead to a demonstration of Majorana braiding.

doi: 10.1038/nature23468

化学:ジスプロソセニウムにおける60 Kでの分子の磁気ヒステリシス

Molecular magnetic hysteresis at 60 kelvin in dysprosocenium p.439

Magnetic hysteresis is observed in a dysprosocenium complex at temperatures of up to 60 kelvin, the origin of which is the localized metal–ligand vibrational modes unique to dysprosocenium.

doi: 10.1038/nature23447


Minimal geological methane emissions during the Younger Dryas–Preboreal abrupt warming event p.443

Measurements from Antarctic ice suggest that geological methane emissions are much lower than previously thought, and that methane emissions from hydrates and permafrost in response to climate warming are minimal.

doi: 10.1038/nature23316


Mutation predicts 40 million years of fly wing evolution p.447

A detailed analysis of fly wing phenotypes reveals a strong positive relationship between variation produced by mutation, standing genetic variation, and evolutionary rate over the past 40 million years.

doi: 10.1038/nature23473


Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis p.451

Myofibroblast-derived R-spondin 3 orchestrates regeneration of antral stomach epithelium via Wnt signalling in Axin2+ stem cells.

doi: 10.1038/nature23642

幹細胞:Polyloxバーコーディングによってin vivoで明らかになった造血幹細胞の運命

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo p.456

An artificial recombination locus, Polylox, that can generate hundreds of thousands of individual barcodes is used to trace the fates of haematopoietic stem cells in mice.

doi: 10.1038/nature23653


cGAS surveillance of micronuclei links genome instability to innate immunity p.461

The cytoplasmic DNA sensor cGAS detects DNA in ruptured micronuclei and activates an innate immune response.

doi: 10.1038/nature23449


Mitotic progression following DNA damage enables pattern recognition within micronuclei p.466

The authors report a link between mitosis, the formation of micronuclei and DNA-damage-induced cGAS-dependent inflammation.

doi: 10.1038/nature23470


CDK4/6 inhibition triggers anti-tumour immunity p.471

Mouse models of breast carcinoma and other solid tumours show that selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors not only induce tumour cell cycle arrest but also promote anti-tumour immunity.

doi: 10.1038/nature23465


Vaccine-driven pharmacodynamic dissection and mitigation of fenethylline psychoactivity p.476

A vaccine-driven approach shows that the prominent stimulant features of the psychoactive profile of fenethylline can be attributed to amphetamine, with synergistic support from theophylline, and no direct contributions from the parent drug molecule.

doi: 10.1038/nature23464


Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure p.480

The authors report the crystal structure of the β2 adrenergic receptor in complex with compound 15, an allosteric modulator that binds to an alternative binding pocket.

doi: 10.1038/nature23652

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