Volume 536 Number 7617



Go forth and replicate! p.373

To make replication studies more useful, researchers must make more of them, funders must encourage them and journals must publish them.

doi: 10.1038/536373a



Earth-sized planet around nearby star is astronomy dream come true p.381

Planet orbiting Proxima Centauri is likely to be the focus of future interstellar voyages.

doi: 10.1038/nature.2016.20445


US personalized-medicine industry takes hit from Supreme Court p.382

Recent decisions seem to drive spike in patent rejections.

doi: 10.1038/nature.2016.20436


China, Japan, CERN: Who will host the next LHC? p.383

Labs are vying to build ever-bigger colliders against a backdrop of uncertainty about how particle physicists will make the next big discoveries.

doi: 10.1038/nature.2016.20453


Obama’s science legacy: betting big on biomedical science p.385

Ambitious bids to map the brain and cure cancer have not boosted overall research funding.

doi: 10.1038/536385a

Obama’s science legacy: a space race stalls p.386

A crewed trip to Mars is still decades away.

doi: 10.1038/536386a

Obama’s science legacy: uneven progress on scientific integrity p.386

US agencies have adopted stronger policies but have not always followed them.

doi: 10.1038/536386b

Obama’s science legacy: climate (policy) hots up p.387

President sidesteps Congress to curb US greenhouse-gas emissions.

doi: 10.1038/536387a

News Features


Busting the billion-dollar myth: how to slash the cost of drug development p.388


doi: 10.1038/536388a

News & Views


Robotics: Generation soft p.400


doi: 10.1038/536400a


Cancer metabolism: Friendly neighbours feed tumour cells p.401


doi: 10.1038/nature19420


Structural biology: Signal locked in p.402


doi: 10.1038/nature19418


Inorganic chemistry: Fleeting glimpse of an elusive element p.404


doi: 10.1038/536404a


Neuroscience: Memories linked within a window of time p.405


doi: 10.1038/536405a


Cell division: Mitotic regulation comes into focus p.407


doi: 10.1038/nature19423


Astronomy: Earth-like planet around Sun's neighbour p.408


doi: 10.1038/536408a



Early onset of industrial-era warming across the oceans and continents p.411

Reconstructions of ocean and land temperatures since ad 1500 indicate that sustained, industrial-era warming of land areas in the Northern Hemisphere and tropical oceans began earlier than previously thought, around the mid-nineteenth century.

doi: 10.1038/nature19082


Genomic insights into the origin of farming in the ancient Near East p.419

Analysis of DNA from ancient individuals of the Near East documents the extreme substructure among the populations which transitioned to farming, a structure that was maintained throughout the transition from hunter–gatherer to farmer but that broke down over the next five thousand years.

doi: 10.1038/nature19310


Uncovering Earth’s virome p.425

An integrated computational approach that explores the viral content of more than 3,000 metagenomic samples collected globally highlights the existing global viral diversity, increases the known number of viral genes by an order of magnitude, and provides detailed insights into viral distribution across diverse ecosystems and into virus–host interactions.

doi: 10.1038/nature19094


Molecular basis of APC/C regulation by the spindle assembly checkpoint p.431

A high-resolution structure of a complex between the anaphase-promoting complex (APC/C) and the mitotic checkpoint complex (MCC) reveals how MCC interacts with and represses APC/C by obstructing substrate recognition and suppressing E3 ligase activity.

doi: 10.1038/nature19083



A terrestrial planet candidate in a temperate orbit around Proxima Centauri p.437

A small planet of at least 1.3 Earth masses is orbiting Proxima Centauri with a period of about 11.2 days, with the potential for liquid water on its surface.

doi: 10.1038/nature19106


Extending the lifetime of a quantum bit with error correction in superconducting circuits p.441

A quantum-error-correction system is demonstrated in which natural errors due to energy loss are suppressed by encoding a logical state as a superposition of Schrödinger-cat states, which results in the system reaching the ‘break-even’ point, at which the lifetime of a qubit exceeds the lifetime of the constituents of the system.

doi: 10.1038/nature18949


Molecular modifiers reveal a mechanism of pathological crystal growth inhibition p.446

Like citrate, the molecule hydroxycitrate is shown to inhibit growth of the crystal that is the principal component of kidney stones, suggesting that hydroxycitrate could be another treatment for kidney stone disease.

doi: 10.1038/nature19062


An integrated design and fabrication strategy for entirely soft, autonomous robots p.451

An untethered, entirely soft robot is designed to operate autonomously by combining microfluidic logic and hydrogen peroxide as an on-board fuel supply.

doi: 10.1038/nature19100


Biodiversity at multiple trophic levels is needed for ecosystem multifunctionality p.456

Both a high number of species and abundance in multiple trophic levels are required for ecosystems to continue to provide the services humans require of them.

doi: 10.1038/nature19092


The TRPM2 ion channel is required for sensitivity to warmth p.460

The neuronal mechanism for the detection of non-painful warm stimuli has remained unclear; mammalian TRPM2 ion channel is shown to be required for warmth detection in the non-noxious range of 33–38 °C, and surprisingly to mediate responses to warmth in the autonomic nervous system.

doi: 10.1038/nature19074


The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6 p.464

The cellular prion protein PrPC promotes peripheral myelin homeostasis by acting on a G protein-coupled receptor to increase levels of cyclic AMP in Schwann cells.

doi: 10.1038/nature19312


DWARF14 is a non-canonical hormone receptor for strigolactone p.469

Structural, biochemical, mass spectrometry and genetic analyses define Arabidopsis thaliana AtD14 as a non-canonical hormone receptor for strigolactone, which hydrolyses strigolactone into a covalently linked intermediate molecule and undergoes an open-to-closed state transition for interaction with D3 to trigger strigolactone signalling.

doi: 10.1038/nature19073


Vaccine protection against Zika virus from Brazil p.474

The authors test several candidate vaccines for Zika virus in mouse models and show that single-shot DNA vaccines and inactivated virus vaccines provide complete protection against Zika virus isolates from Brazil and Puerto Rico.

doi: 10.1038/nature18952


Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion p.479

Pancreatic adenocarcinoma cells drive autophagy in tumour microenvironment-associated stellate cells, which release alanine that is used by the cancer cells as a carbon source for a variety of metabolic processes in an otherwise nutrient-poor environment.

doi: 10.1038/nature19084

構造生物学:クラスA GPCRに見られる多様な活性化経路は、Gタンパク質結合領域周辺では高い類似性を示す

Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region p.484

A highly conserved rearrangement of residue contacts functions as a common step in the activation pathways of diverse G-protein-coupled receptors.

doi: 10.1038/nature19107

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