A catalogue of genetic information from some 60,000 people reveals unexpected surprises — and highlights the need to make genomic data publicly accessible to aid studies of rare diseases.
doi: 10.1038/536249a
Modern gene-editing tools are being used to understand the mechanisms of evolution.
doi: 10.1038/536249b
It is one of the last Caribbean countries to get hit.
doi: 10.1038/536257a
Result could be closest thing yet to an observation of the bizarre phenomenon.
doi: 10.1038/536258a
Cash-strapped Zewail City of Science and Technology is the legacy of Arab chemist Ahmed Zewail.
doi: 10.1038/nature.2016.20408
Ecologists fear plan to seal off the United States from Mexico would put wildlife at risk.
doi: 10.1038/536260a
Excitement rises over chance of new physics from particle-du-jour.
doi: 10.1038/nature.2016.20405
世界の海に大量のプラスチックがたまっていることは知られているが、どこに、どのような状態で存在し、どのような害があるかは分かっていない。
doi: 10.1038/536263a
現代の生活のほぼ全ての場面で使われているポリマーの限界が、新世代のプラスチックの研究によってさらに広がりつつある。
doi: 10.1038/536266a
一群の｢リビング」重合反応が1950年代に開発されたことは、高分子の分子量分布を制御する方法へとつながり、高分子科学の分野に大きな変革を引き起こした。その影響は現在にも及んでいる。
doi: 10.1038/536276a
エキソームは、ゲノムの中のタンパク質をコードしている領域である。14の研究に由来する6万706人のエキソームの塩基配列を収集したデータを使って、ヒトでの遺伝的変動についての綿密な考察がなされた。
doi: 10.1038/536277a
一群の睡眠促進ニューロンをドーパミンシグナルの伝達によって不活性化すると、ショウジョウバエでは2種類のカリウムチャネルタンパク質での変化に依存して、急性的あるいは慢性的な覚醒状態がもたらされることが分かった。
doi: 10.1038/nature18918
鉄を含む触媒の活性部位が突き止められた。これによって、自動車の燃料になると考えられているメタノールへと、メタンを室温で変換する反応に実際に役立ちそうな触媒が設計されることが期待されている。
doi: 10.1038/536280a
哺乳類の胚発生の際に細胞が最初の系譜決定を行う仕組みを説明する仮説は複数存在する。全てを包括する1つの機構を考えることで、これらの本質的に異なるモデルを統一できることが今回明らかになった。
doi: 10.1038/nature18920
電荷キャリア密度が高いオーバードープされた高温超伝導体の性質はすでに解明されたと考えられてきた。だが1つの実験が、このような系の量子物理学的性質に関する我々の知識に対して疑問を投げ掛けている。
doi: 10.1038/536282a
Exome sequencing data from 60,706 people of diverse geographic ancestry is presented, providing insight into genetic variation across populations, and illuminating the relationship between DNA variants and human disease.
doi: 10.1038/nature19057
A subset of dorsal clock neurons are identified in Drosophila as sleep-promoting cells, which participate in a feedback loop with pacemaker neurons to drive both midday siesta and night-time sleep.
doi: 10.1038/nature19097
Skin stem cells, but not their progenitors, are able to form tumours owing to the ability of oncogene-targeted stem cells to increase symmetric self-renewing division and a higher p53-dependent resistance to apoptosis.
doi: 10.1038/nature19069
A new method based on protein engineering to trap an intact complex between Siz1, SUMO-bound E2, and PCNA for structure determination.
doi: 10.1038/nature19071
The scaling law for the critical temperature and zero-temperature stiffness in an overdoped copper oxide semiconductor does not conform to the standard Bardeen–Cooper–Schrieffer description.
doi: 10.1038/nature19061
Thin-film solar cells were fabricated using layered two-dimensional perovskites with near-single-crystalline out-of-plane alignment, which facilitates efficient charge transport leading to greatly improved power conversion efficiency with technologically relevant stability to light exposure, humidity and heat stress.
doi: 10.1038/nature18306
Iron-containing zeolites have an exceptional ability to convert methane into methanol, but their active site have been hard to study; now, magnetic circular dichroism has been used to explore the reactive species, providing a technique that should be generally applicable, and revealing the value of constraining active sites within a lattice to improve catalyst functionality.
doi: 10.1038/nature19059
The long-sought direct formation of a bond between two sp3-hybridized carbon atoms is achieved by the merger of photoredox and nickel catalysis using only simple carboxylic acids and alkyl halides as starting materials.
doi: 10.1038/nature19056
Experiments show that magnesium oxide can dissolve in core-forming metallic melts at very high temperatures; core formation models suggest that a giant impact during Earth’s accretion could have contributed large amounts of magnesium to the early core, the subsequent exsolution of which would have generated enough gravitational energy to power an early geodynamo and produce an ancient magnetic field.
doi: 10.1038/nature18594
Natural variation in the courtship song of Drosophila is mapped to the intronic insertion of a retroelement at the slowpoke locus, which encodes an ion channel.
doi: 10.1038/nature19093
Sleep-promoting neurons in Drosophila are shown to switch between electrical activity and silence as a function of sleep need; the switch is operated by dopamine and involves the antagonistic regulation of two potassium channels.
doi: 10.1038/nature19055
A human neurodevelopmental model fills the current knowledge gap in the cellular biology of Williams syndrome and could lead to further insights into the molecular mechanism underlying the disorder and the human social brain.
doi: 10.1038/nature19067
Here, a combination of biophysical measurement, modelling, and genetic and experimental manipulation of cell contractile components is used to analyse the formation of the inner cell mass in the early mouse embryo.
doi: 10.1038/nature18958
Size-selective pores in the HIV-1 capsid hexamer recruit nucleotides, thereby allowing reverse transcription to take place inside the capsid.
doi: 10.1038/nature19098
Electron cryomicroscopy structures are provided for all core and supernumerary protein subunits of mammalian complex I, a 45-subunit enzyme that powers eukaryotic respiration.
doi: 10.1038/nature19095
