Volume 520 Number 7547



Numbers matter p.263

Researchers need help in making the statistical power of animal experiments clear.

doi: 10.1038/520263b


Close the deal p.263

Science-based evidence and enlightened diplomacy have brought within reach a historic opportunity for nuclear détente with Iran. It must be seized.

doi: 10.1038/520263a


Announcement: Time to tackle cells’ mistaken identity p.264

doi: 10.1038/520264a



UK funders demand strong statistics for animal studies p.271

Move addresses concerns that some experiments are not using enough animals.

doi: 10.1038/520271a


Canadians baulk at reforms to health-research agency p.272

Biomedical-funding revamp threatens to marginalize under-represented researchers.

doi: 10.1038/520272a


The printed organs coming to a body near you p.273

From kidneys to hands, 3D printers are churning out made-to-order bones and rudimentary organs.

doi: 10.1038/520273a


Iran nuclear deal raises hopes for science p.274

ranian physicists excited at prospects for a new physics lab and greater collaboration with the rest of the world.

doi: 10.1038/520274a


Leading scientists favour women in tenure-track hiring test p.275

US science and engineering professors preferred female job candidates by two to one.

doi: 10.1038/520275a

Nature Biotechnologyでは、コンピューターを使った研究についてソフトウェアも検証するよう、査読者へ要請を。

Rule rewrite aims to clean up scientific software p.276

Nature Biotechnology asks peer reviewers to check accessibility of code used in computational studies.

doi: 10.1038/520276a

News Features


Cancer: The Ras renaissance p.278


doi: 10.1038/520278a


Biography of a space telescope: Voices of Hubble p.282


doi: 10.1038/520282a

News & Views


Cancer: The complex seeds of metastasis p.298


doi: 10.1038/nature14377


Planetary science: A new recipe for Earth formation p.299


doi: 10.1038/520299a


Cancer: An extravascular route for tumour cells p.300


doi: 10.1038/nature14382


Organic chemistry: Streamlining drug synthesis p.302


doi: 10.1038/520302a


Particle physics: A weighty mass difference p.303


doi: 10.1038/nature14381


Ecology: Recovering the potential of coral reefs p.304


doi: 10.1038/nature14384



A resource for cell line authentication, annotation and quality control p.307

Competing financial interests. The majority of authors are employees of Genentech Inc. and/or hold stock in Roche.

doi: 10.1038/nature14397



Crystal structures of the human adiponectin receptors p.312

The crystal structures of the human adiponectin receptors AdipoR1 and AdipoR2 are solved at 2.9 and 2.4 Å resolution, respectively; the structural and functional information may aid the development and optimization of adiponectin receptor agonists for the treatment of obesity-related diseases.

doi: 10.1038/nature14301


Two disparate ligand-binding sites in the human P2Y1 receptor p.317

Two X-ray crystal structures are presented of the human P2Y1 G-protein-coupled receptor, which is an important target for anti-thrombotic drugs; the structures unexpectedly reveal two ligand-binding sites.

doi: 10.1038/nature14287


宇宙物理学:爆発星Nova Vul 1670における核の灰とアウトフロー

Nuclear ashes and outflow in the eruptive star Nova Vul 1670 p.322

Observations of CK Vulpeculae reveal that it is surrounded by molecular gas and dust whose large mass and chemical composition cannot have come from a nova; the best explanation is that this object is the remnant of the merger of two stars.

doi: 10.1038/nature14257


An ultrafast rechargeable aluminium-ion battery p.325

An aluminium-ion battery is reported that can charge within one minute, and offers improved cycle life compared to previous devices; it operates through the electrochemical deposition and dissolution of aluminium at the anode, and the intercalation/de-intercalation of chloroaluminate anions into a novel graphitic-foam cathode.

doi: 10.1038/nature14340


Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts p.329

The continuous-flow synthesis of both enantiomers of a complex molecule, the anti-inflammatory drug rolipram, is described, using only columns packed with achiral and chiral heterogeneous catalysts, thus enabling batch processing to be avoided.

doi: 10.1038/nature14343


Icebergs not the trigger for North Atlantic cold events p.333

A delay between surface cooling and the arrival of ice-rafted debris at a site southwest of Iceland over the past four glacial cycles implies that icebergs typically arrived too late to have triggered cooling, although the freshwater derived from melting icebergs may provide a positive feedback for cold stadial conditions.

doi: 10.1038/nature14330


A Mercury-like component of early Earth yields uranium in the core and high mantle 142Nd p.337

High pressure experiments show that addition of a reduced sulfur-rich body to Earth during its accretion would provide enough energy to power the core’s geodynamo and, by fractionating neodymium relative to samarium, would explain the observed enrichment of Earth’s mantle in neodymium-142.

doi: 10.1038/nature14350


Recovery potential of the world's coral reef fishes p.341

A study of the recovery potential of over 800 of the world's coral reefs shows that 83% of fished reefs are missing more than half their expected biomass, with severe consequences for key ecosystem functions; protection from fishing would allow full recovery in 35 years on average, but in 59 years for the most degraded reefs.

doi: 10.1038/nature14358


Emotional learning selectively and retroactively strengthens memories for related events p.345

Initially weak episodic memories in humans can be selectively enhanced and consolidated following later emotional learning involving conceptually related information, suggesting a mechanism for how we can remember initially inconsequential information after a relevant later experience.

doi: 10.1038/nature14106


Thirst driving and suppressing signals encoded by distinct neural populations in the brain p.349

Two genetically distinct populations of neurons in the subfornical organ of mice can either induce thirst and water-seeking behaviour or suppress thirst, regardless of the hydration status of the animal.

doi: 10.1038/nature14108


The evolutionary history of lethal metastatic prostate cancer p.353

The subclonal composition of human prostate tumours and their metastases has been mapped by whole-genome sequencing, thus establishing the evolutionary trees behind the development and spread of these cancers; an important observation was that metastases could be re-seeded multiple times, and spread from one tumour to another was frequently seen.

doi: 10.1038/nature14347


A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis p.358

Different clones of a mammary tumour cell line possess differential abilities to contribute to the formation of metastasis; the expression of Serpine2 and Slp1 proteins drives vascular mimicry and metastasis to the lung, with similar associations observed in human data sets, and these proteins also function as anticoagulants, thus further promoting extravasation of tumour cells.

doi: 10.1038/nature14403


SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance p.363

Tumours are a low-oxygen environment, in this study glioblastoma cells are found to overexpress the serine hydroxymethyltransferase SHMT2; SHMT acts to reduce oxygen consumption, which confers the tumour cells with a survival advantage.

doi: 10.1038/nature14363


Therapy-induced tumour secretomes promote resistance and tumour progression p.368

Tumour cells respond to an effective, targeted drug treatment with BRAF, ALK or EGFR kinase inhibitors by inducing a complex network of secreted signals that promote tumour growth, dissemination and metastasis of drug-resistant cancer cell clones, and increase the survival of drug-sensitive tumour cells, potentially contributing to incomplete tumour regression.

doi: 10.1038/nature14336


Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer p.373

In this study, involving melanoma patients and a mouse model for melanoma, an optimal anti-tumour response was induced by using a combination of radiation with anti-CTLA4 and anti-PD-L1 antibody therapies, each attacking the tumour from a different angle.

doi: 10.1038/nature14292


Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation p.378

Parasites of the Theileria genus infect cattle and transform their host cells, a transformation that can be reversed by treatment with the drug buparvaquone; here, a Theileria homologue of the peptidyl-prolyl isomerase PIN1 is shown to be secreted into the host cell, where it promotes transformation and can be directly inhibited by buparvaquone.

doi: 10.1038/nature14044


β-Lactam formation by a non-ribosomal peptide synthetase during antibiotic biosynthesis p.383

The monocyclic β-lactam rings of the nocardicin family of antibiotics are biosynthesized by an unprecedented activity of non-ribosomal peptide synthetases, a mechanism that is distinct from the pathways to the other classes of β-lactam antibiotics.

doi: 10.1038/nature14100

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