Volume 510 Number 7506



Biosafety in the balance p.443

An accident with anthrax demonstrates that pathogen research always carries a risk of release — and highlights the need for rigorous scrutiny of gain-of-function flu studies.

doi: 10.1038/510443a


Storm warning p.444

Environmentalists are divided over whether it is possible to have a ‘good’ Anthropocene.

doi: 10.1038/510444b


Metrics market p.444

Measures of research impact are improving, but universities should be wary of their limits.

doi: 10.1038/510444a



NASA carbon-monitoring orbiter readies for launch p.451

Satellite will map sources and sinks of greenhouse gas in unprecedented detail.

doi: 10.1038/510451a


Africa science plan attacked p.452

Proposed innovation strategy is low on detail and commitments from governments.

doi: 10.1038/510452a


Resurrected cancer drug faces regulators p.454

Despite a chequered history, olaparib is finally before the US Food and Drug Administration.

doi: 10.1038/510454a


‘Life on Earth’ project gets under way p.455

Assessments by international biodiversity group aim to halt damage to world’s ecosystems.

doi: 10.1038/510455a


Brain wave hits California p.456

State creates programme to boost neuroscience innovation.

doi: 10.1038/510456a

News Features


Love in the lab: Close collaborators p.458


doi: 10.1038/510458a


Nutrition: Vitamins on trial p.462


doi: 10.1038/510462a

News & Views


Nuclear-weapons dismantlement: Identifying a hidden warhead p.476


doi: 10.1038/510476a


Antibiotic resistance: To the rescue of old drugs p.477


doi: 10.1038/510477a


Fundamental constants: A cool way to measure big G p.478


doi: 10.1038/nature13507


Structural biology: Wobble puts RNA on target p.480


doi: 10.1038/nature13502


Applied physics: Trawling for complements p.481


doi: 10.1038/510481a


Structural biology: Enzyme assembly line pictured p.482


doi: 10.1038/nature13505



An overview of N-heterocyclic carbenes p.485

N-heterocyclic carbenes are powerful tools in organic chemistry, with many commercially important applications; this overview describes their properties and potential uses.

doi: 10.1038/nature13384



A zero-knowledge protocol for nuclear warhead verification p.497

Future rounds of nuclear arms control would ideally involve direct inspection of nuclear warheads using procedures that give inspectors high confidence about the authenticity of submitted nuclear items yet give no information about their design; this is now shown to be achievable using zero-knowledge protocols in neutron imaging of nuclear warheads.

doi: 10.1038/nature13457


Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance p.503

The emergence of Gram-negative pathogens resistant to carbapenem antibiotics is a global health concern and carbapenem resistance often arises through acquisition of β-lactamase enzymes; this study identifies the natural fungal product aspergillomarasmine A as a metallo-β-lactamase inhibitor and a potential treatment to tackle carbapenem resistance.

doi: 10.1038/nature13445


The selective tRNA aminoacylation mechanism based on a single G•U pair p.507

X-ray crystal structures of a tRNA synthetase bound to wild-type and mutant alanine tRNAs reveal the structural basis for selectivity.

doi: 10.1038/nature13440


Structure of a modular polyketide synthase p.512

Polyketide synthases are multidomain enzymes that produce polyketides, which form the basis of many therapeutic agents; here, electron cryo-microscopy is used to establish the structure of a bacterial full-length module, and to elucidate the structural basis of both intramodule and intermodule substrate transfer.

doi: 10.1038/nature13423



Precision measurement of the Newtonian gravitational constant using cold atoms p.518

Determination of the gravitational constant G using laser-cooled atoms and quantum interferometry, a technique that gives new insight into the systematic errors that have proved elusive in previous experiments, yields a value that has a relative uncertainty of 150 parts per million and which differs from the current recommended value by 1.5 combined standard deviations.

doi: 10.1038/nature13433


Chirality-specific growth of single-walled carbon nanotubes on solid alloy catalysts p.522

Single-walled carbon nanotubes of a single chirality can be produced with an abundance of more than 92 per cent when using tungsten-based bimetallic alloy nanocrystals as catalysts.

doi: 10.1038/nature13434


South Greenland ice-sheet collapse during Marine Isotope Stage 11 p.525

The isotopic composition of glacial sediment discharged into the ocean from south Greenland is used to identify a major reduction in the amount of that sediment derived from erosion of Greenland’s Precambrian bedrock, probably indicating the cessation of subglacial erosion and sediment transport during Marine Isotope Stage 11 as a result of the almost complete deglaciation of south Greenland.

doi: 10.1038/nature13456


Purkinje-cell plasticity and cerebellar motor learning are graded by complex-spike duration p.529

Recordings from monkeys during motor learning suggest that durations of complex-spike (CS) responses to climbing-fibre inputs are meaningful signals correlated across the Purkinje-cell population during motor learning; longer climbing-fibre bursts lead to longer-duration CS responses, larger synaptic depression and stronger learning, thus forming a graded instruction.

doi: 10.1038/nature13282


Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells p.533

Here human embryonic stem cell lines are derived by somatic cell nuclear transfer from cells of a newborn and from skin cells of an adult, a female with type 1 diabetes; the stem cells produced are pluripotent and can be differentiated into insulin-producing beta cells.

doi: 10.1038/nature13287


Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing p.537

Medulloblastoma is a malignant childhood brain tumour presenting major clinical challenges; here, a comprehensive genome-wide DNA methylation data set from human and mouse tumours, coupled with analysis of histone modifications, RNA transcripts and genome sequencing, uncovers a wealth of alterations that provide insights into the epigenetic regulation of transcription and genome organization in medulloblastoma pathogenesis.

doi: 10.1038/nature13268


Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase p.542

Metformin treatment of rats at physiologically relevant doses inhibits the redox shuttle enzyme mitochondrial glycerophosphate dehydrogenase.

doi: 10.1038/nature13270


Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression p.547

Formation of an active cyclin D1–Cdk4 complex suppresses glucose metabolism independently of cell division.

doi: 10.1038/nature13267


Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer p.552

Several proteins localized at membrane contact sites contain an SMP domain, which has been proposed to act as a lipid-binding module; here, the crystal structure of a fragment of the extended synaptotagmin 2 protein, including its SMP, is presented, and indicates that this protein may have a direct role in lipid transport.

doi: 10.1038/nature13269


BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks p.556

Direct evidence for the role of BRCA1 in controlling homologous recombination at stalled replication forks has been obtained in mammalian cells using the bacterial Tus/Ter system.

doi: 10.1038/nature13295


Structural rearrangements of a polyketide synthase module during its catalytic cycle p.560

Polyketide synthases (PKSs) are multidomain enzymes that produce polyketides, which form the basis of many therapeutic agents; here, electron cryo-microscopy is used to probe the structure of an intact module of a multi-enzyme PKS in different functional states.

doi: 10.1038/nature13409

「Journal home」に戻る