Volume 546 Number 7656



Why function is catching on in conservation p.7

Counting what species do is becoming as important as counting how many there are.

doi: 10.1038/nature.2017.22058


Keep shouting to save science p.7

As political leaders on either side of the Atlantic set out contrasting positions on science funding, researchers everywhere need to ensure that their voices are heard.

doi: 10.1038/546007a

Nature Researchは、科学論文の再現性を一層高めるために、実験手法や統計解析の詳細なレポートの添付を求める。

Announcement: Towards greater reproducibility for life-sciences research in Nature p.8

doi: 10.1038/546008a



Trials of embryonic stem cells to launch in China p.15

Studies to treat vision loss and Parkinson’s disease are the first to proceed under new regulations.

doi: 10.1038/546015a


UK election: science spending pledges overshadowed by Brexit p.16

Parties promise more money for research, but scientists fear impact of split with European Union.

doi: 10.1038/546016a


Mummy DNA unravels ancient Egyptians’ ancestry p.17

Genetic analysis reveals a close relationship with Middle Easterners, not central Africans.

doi: 10.1038/546017a


Neutron stars set to open their heavy hearts p.18

Space mission will peer inside the densest matter in the Universe.

doi: 10.1038/546018a


Trump budget would slash science programmes across government p.19

Proposed cuts include 11% at the National Science Foundation, 18% at the National Institutes of Health and 30% at the Environmental Protection Agency.

doi: 10.1038/nature.2017.22036

News Features


Biodiversity moves beyond counting species p.22


doi: 10.1038/546022a

News & Views


Structural biology: Signalling under the microscope p.36


doi: 10.1038/nature22491


Astrophysics: Multi-molecular views of a stellar nursery p.37


doi: 10.1038/nature22499


Cell imaging: An intracellular dance visualized p.39


doi: 10.1038/nature22500


Condensed-matter physics: Functional materials at the flick of a switch p.40


doi: 10.1038/546040a


Atmospheric science: The self-cleansing ability of prehistoric air p.41


doi: 10.1038/546041a


Genomics: Sunflowers sequenced p.43

栽培種のヒマワリ(Helianthus annuus L.)の参照ゲノムは、この作物のストレス耐性と油脂生産の向上を目的とした育種計画の有用なリソースになる見込みがある。

doi: 10.1038/546043a


Microbiology: Diversity breeds tolerance p.44


doi: 10.1038/546044a


Biomedical research: Premature lambs grown in a bag p.45


doi: 10.1038/546045a



A neural circuit architecture for angular integration in Drosophila p.101

A neural circuit in Drosophila reveals how the fly’s internal sense of heading rotates when it turns.

doi: 10.1038/nature22343


Blocking FSH induces thermogenic adipose tissue and reduces body fat p.107

An antibody against the pituitary hormone Fsh reduces adiposity and increases thermogenesis in ovariectomized mice or mice fed a high-fat diet.

doi: 10.1038/nature22342


Ensemble cryo-EM elucidates the mechanism of translation fidelity p.113

Structural ensembles of the 70S ribosome bound to cognate or near-cognate charged tRNAs in complex with EF-Tu illustrate the crucial role of the nucleotide G530 in decoding of mRNA, and demonstrate that translational fidelity results from direct control of GTPase by the decoding centre.

doi: 10.1038/nature22397


Phase-plate cryo-EM structure of a class B GPCR–G-protein complex p.118

Volta phase-plate cryo-electron microscopy reveals the structure of the full-length calcitonin receptor in complex with its peptide ligand and Gαsβγ.

doi: 10.1038/nature22327



Electric-field control of tri-state phase transformation with a selective dual-ion switch p.124

Materials are described here that can change their crystalline phase in response to the electrically controlled insertion or extraction of oxygen and hydrogen ions, giving rise to three distinct phases with different optical, electrical and magnetic properties.

doi: 10.1038/nature22389


Femtosecond response of polyatomic molecules to ultra-intense hard X-rays p.129

Upon exposure to ultra-intense, hard X-ray pulses, polyatomic molecules containing one heavy atom reach a much higher degree of ionization than do individual heavy atoms, contrary to previous assumptions.

doi: 10.1038/nature22373


Isotopic evidence of multiple controls on atmospheric oxidants over climate transitions p.133

Observations from a Greenland ice core reveal that tropospheric oxidants are sensitive to climate-driven changes in reactive halogen chemistry and stratosphere-to-troposphere transport of ozone, in addition to ozone precursor emissions.

doi: 10.1038/nature22340


Extreme hydrothermal conditions at an active plate-bounding fault p.137

Extreme temperatures and fluid pressures are measured, and their causes modelled, in a borehole into the Alpine Fault, where an earthquake rupture is expected within the next few decades.

doi: 10.1038/nature22355


Large conservation gains possible for global biodiversity facets p.141

Expanding protected areas for ecological conservation by just 5% has the potential to markedly increase terrestrial biodiversity protection.

doi: 10.1038/nature22368


Leaf bacterial diversity mediates plant diversity and ecosystem function relationships p.145

A tree biodiversity and ecosystem function experiment shows that leaf bacterial diversity is positively related to plant community productivity, and explains a portion of the variation in productivity that would otherwise be attributed to plant diversity and functional traits.

doi: 10.1038/nature22399


The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution OPEN p.148

A high-quality reference for the sunflower genome (Helianthus annuus L.) and analysis of gene networks involved in flowering time and oil metabolism provide a basis for nutritional exploitation and analyses of adaptation to climate change.

doi: 10.1038/nature22380


Deletion of a mycobacterial divisome factor collapses single-cell phenotypic heterogeneity p.153

The mycobacterial protein LamA functions as an inhibitor of cell wall synthesis at the nascent cell pole, contributing to asymmetry in polar growth, and could represent a much-needed target for the development of anti-tuberculosis therapies.

doi: 10.1038/nature22361


Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells p.158

The chemoattractant S1P is identified as an extrinsic factor that supports naive T cell survival, and acts via a signalling mechanism to maintain mitochondrial content and function.

doi: 10.1038/nature22352


Applying systems-level spectral imaging and analysis to reveal the organelle interactome p.162

Using confocal and lattice light sheet microscopy, the authors perform systems-level analysis of the organelle interactome in live cells, allowing them to visualize the frequency and locality of up to five-way interactions between different organelles.

doi: 10.1038/nature22369


CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells p.168

In human cell lines with mutant KRAS and loss of LKB1, CPS1 expression correlates inversely with LKB1 expression; silencing CPS1 in these cells induces DNA damage and cell death as a result of pyrimidine depletion rather than ammonia toxicity.

doi: 10.1038/nature22359

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