Volume 546 Number 7657



Six decades of struggle over the pill p.185

A notable anniversary highlights the progress and benefits of contraceptives, but also the continuing battle for access to them.

doi: 10.1038/546185a


Rare particle decays offer hope of new physics p.185

The strange and subtle behaviour of B mesons could crack open the standard model.

doi: 10.1038/546185b


A sugar high in structural biology p.186

Four Nature papers describing the receptor structures involved in glucose metabolism hold great promise for finding new ways to treat diabetes.

doi: 10.1038/546186a



Italy rebuked for failure to prevent olive-tree tragedy p.193

European Commission reveals widespread delays by the country’s authorities to halt spread of deadly plant disease.

doi: 10.1038/546193a


NASA’s dark-energy probe faces cost crisis p.195

Space agency takes a hard look at plans for its next big space observatory.

doi: 10.1038/546195a


AI summit aims to help world’s poorest p.196

United Nations meeting hopes to focus artificial intelligence on sustainable development goals.

doi: 10.1038/546196a


Romania’s science reforms prompt boycott p.197

Researchers refuse to sit on evaluation panels after government bans international participation.

doi: 10.1038/546197a


Trump pulls United States out of Paris climate agreement p.198

Withdrawal from global pact may take almost four years — which could give the winner of the 2020 presidential race the final word.

doi: 10.1038/nature.2017.22096

News Features


The mathematicians who want to save democracy p.200


doi: 10.1038/546200a

News & Views


Palaeoanthropology: On the origin of our species p.212


doi: 10.1038/546212a


Optical physics: One ring to multiplex them all p.214


doi: 10.1038/546214a


Neurodegenerative disease: RNA repeats put a freeze on cells p.215


doi: 10.1038/nature22503


Magnetism in flatland p.216


doi: 10.1038/546216a


Evolution: Differences can hold populations together p.218


doi: 10.1038/nature22502


Climate science: Cracking the palaeoclimate code p.219


doi: 10.1038/nature22501



Flavour-changing neutral currents making and breaking the standard model p.221

doi: 10.1038/nature21721


A challenge to lepton universality in B-meson decays p.227

doi: 10.1038/nature22346


Nutrient acquisition strategies of mammalian cells p.234

doi: 10.1038/nature22379



RNA phase transitions in repeat expansion disorders p.243

Nucleotide repeat expansions create templates for multivalent base-pairing, which causes RNA to undergo a sol–gel phase transition and may explain the formation of nuclear RNA foci that are commonly observed in several neurological and neuromuscular diseases.

doi: 10.1038/nature22386


Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein p.248

The structure of the GLP-1 receptor complexed with its ligand offers insight into the mechanism of class B G-protein-coupled receptor activation.

doi: 10.1038/nature22394


Crystal structure of the GLP-1 receptor bound to a peptide agonist p.254

The solved crystal structure of the GLP-1 receptor bound to a truncated agonist enables the design of synthetic agonists that exhibit potent activity in vivo.

doi: 10.1038/nature22800


Structure of the full-length glucagon class B G-protein-coupled receptor p.259

The crystal structure of the full-length human glucagon receptor reveals the essential role of the 12-residue ‘stalk’ segment and an extracellular loop in the regulation of ligand binding and receptor activation.

doi: 10.1038/nature22363



Discovery of intrinsic ferromagnetism in two-dimensional van der Waals crystals p.265

Intrinsic long-range ferromagnetic order is observed in few-layer Cr2Ge2Te6 crystals, with a transition temperature that can be controlled using small magnetic fields.

doi: 10.1038/nature22060


Layer-dependent ferromagnetism in a van der Waals crystal down to the monolayer limit p.270

Magneto-optical Kerr effect microscopy is used to show that monolayer chromium triiodide is an Ising ferromagnet with out-of-plane spin orientation.

doi: 10.1038/nature22391


Microresonator-based solitons for massively parallel coherent optical communications p.274

Frequency combs produced by solitons in silicon-based optical microresonators are used to transmit data streams of more than 50 terabits per second in telecommunication wavelength bands.

doi: 10.1038/nature22387


Accelerated discovery of two crystal structure types in a complex inorganic phase field p.280

A computational tool that combines human-like chemical understanding with ab initio methods guides the compositional choice of complex five-component metallic oxides, yielding two new complex crystal structures.

doi: 10.1038/nature22374


Frequency dependence limits divergent evolution by favouring rare immigrants over residents p.285

In a study using stickleback fish, negative frequency-dependent selection favours rare immigrants over common residents, weakening the effect of divergent natural selection.

doi: 10.1038/nature22351


New fossils from Jebel Irhoud, Morocco and the pan-African origin of Homo sapiens p.289

New human fossils from Jebel Irhoud (Morocco) document the earliest evolutionary stage of Homo sapiens and display modern conditions of the face and mandible combined with more primative features of the neurocranium.

doi: 10.1038/nature22336


The age of the hominin fossils from Jebel Irhoud, Morocco, and the origins of the Middle Stone Age p.293

Thermoluminescence dating of fire-heated flint artefacts, and directly associated newly discovered remains of Homo sapiens, indicate that the Middle Stone Age site of Jebel Irhoud in Morocco is 383–247 thousand years old.

doi: 10.1038/nature22335


Dynamic corticostriatal activity biases social bonding in monogamous female prairie voles p.297

In a prairie vole (Microtus ochrogaster) model of social bonding, a functional circuit from the prefrontal cortex to nucleus accumbens is dynamically modulated to enhance females’ affiliative behaviour towards a partner.

doi: 10.1038/nature22381


The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition p.302

Combined studies in MYC-driven mouse lymphomas and human Burkitt lymphoma unravel an essential role for the B-cell antigen receptor in the control of tumour B-cell fitness both in vitro and in vivo, with possible biological and clinical implications.

doi: 10.1038/nature22353


Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling p.307

Random mutagenesis in haploid human cells coupled to quantitative protein measurements with different antibodies is used as a readout for individual cellular phenotypes.

doi: 10.1038/nature22376


Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators p.312

Crystal structures of the human GLP-1 receptor in complex with two negative allosteric modulators reveal a common binding pocket, and, together with mutagenesis and modelling studies, further our understanding of the receptor activation mechanism.

doi: 10.1038/nature22378

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