Volume 543 Number 7647



Forensics: Germany considers wider use of DNA evidence in criminal cases p.589

The country may lift its ban on the analysis of gene-coding regions in DNA samples.

doi: 10.1038/543589b


Trump’s pipeline permit is bad for both the US economy and the environment p.589

The US president’s approval of a controversial oil pipeline offers a disturbing glimpse of the future. But he will struggle to get things all his own way.

doi: 10.1038/543589a


An early start on tackling childhood cancers p.590

The most vulnerable cancer patients are drawing the attention they deserve.

doi: 10.1038/543590a



Battle between quantum and thermodynamic laws heats up p.597

Physicists try to rebuild the laws of heat and energy for processes at a quantum scale.

doi: 10.1038/543597a


Canada budget falls flat with scientists p.598

Emphasis on innovation overshadowed by funding freeze for key research councils.

doi: 10.1038/nature.2017.21699


Gates Foundation announces open-access publishing venture p.599

Global health charity is latest funder to start its own publishing ‘channel’ — and the European Commission is considering its own service.

doi: 10.1038/nature.2017.21700


How Brexit is changing the lives of eight researchers p.600

The months between the Brexit vote and this week's triggering of Article 50 have been a turbulent time for scientists — and things show no sign of calming.

doi: 10.1038/nature.2017.21714


Biological underpinnings of chronic fatigue syndrome begin to emerge p.602

Gut bacteria and altered metabolic pathways are suspects in mysterious disease.

doi: 10.1038/543602a

News Features


How giant marine reptiles terrorized the ancient seas p.603


doi: 10.1038/543603a


Cruel fusion: What a young man’s death means for childhood cancer p.608


doi: 10.1038/543608a

News & Views


Cancer: Tumour stem-cell surprises p.626


doi: 10.1038/543626a


Inorganic chemistry: Making iron glow p.627


doi: 10.1038/543627a


In Retrospect: Forty years of cellular clues from worms p.628

1977年に、線虫の一種Caenorhabditis elegansで、幼虫が変態して成虫になる際の細胞分裂が細胞系統樹で記述された。以来この研究は、発生機構に関する多くの発見の基盤となってきた。

doi: 10.1038/543628a


Marine conservation: How to heal an ocean p.630


doi: 10.1038/nature21895


Neuroscience: Auditory landscape on the cognitive map p.631


doi: 10.1038/543631a


Environmental science: Eating ourselves dry p.633


doi: 10.1038/543633a


Cancer therapy: The leukaemia epigenome targeted p.634


doi: 10.1038/543634a


Planetary science: Reckless orbiting in the Solar System p.635


doi: 10.1038/543635a



Exploiting non-covalent π interactions for catalyst design p.637

doi: 10.1038/nature21701


Using coherence to enhance function in chemical and biophysical systems p.647

doi: 10.1038/nature21425



Functional materials discovery using energy–structure–function maps p.657

Energy–structure–function maps that describe the possible structures and properties of molecular crystals are developed, and these maps are used to guide the experimental discovery of porous materials with specific functions.

doi: 10.1038/nature21419


Capacity shortfalls hinder the performance of marine protected areas globally p.665

Although 71% of marine protected areas are benefiting fish populations, their effects are highly variable, with staff capacity proving to be the most important explanatory variable.

doi: 10.1038/nature21708


Neural ensemble dynamics underlying a long-term associative memory p.670

Use of a head-mounted miniature microscope in awake, behaving mice reveals that neural ensembles in the basal and lateral amygdala encode associations between conditioned and unconditioned stimuli in a way that matches models of supervised learning.

doi: 10.1038/nature21682


A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer p.676

Ablation of Lgr5+ cancer stem cells does not result in regression of primary colorectal tumours, but prevents the formation and maintenance of metastasis in the liver.

doi: 10.1038/nature21713


LACTB is a tumour suppressor that modulates lipid metabolism and cell state p.681

LACTB modulates mitochondrial lipid metabolism and changes the differentiation state of breast cancer cells, thereby negatively affecting the growth of various tumorigenic, but not non-tumorigenic, cells both in vitro and in vivo.

doi: 10.1038/nature21408



A retrograde co-orbital asteroid of Jupiter p.687

Asteroid 2015 BZ509 is a retrograde co-orbital asteroid of the planet Jupiter, stably orbiting in a sense opposite to that of Jupiter’s orbit around the Sun for around a million years.

doi: 10.1038/nature22029


Ultra-selective high-flux membranes from directly synthesized zeolite nanosheets p.690

A direct synthesis of high-aspect-ratio microporous zeolite nanosheets and the use of such nanosheets in separation membranes are described.

doi: 10.1038/nature21421

化学:寿命100 psの配位子から金属への電荷移動フォトルミネッセンスを示す低スピンFe(III)錯体

A low-spin Fe(iii) complex with 100-ps ligand-to-metal charge transfer photoluminescence p.695

An iron complex is described that exhibits photoluminescence at room temperature, opening the way to the use of iron-based materials as low-cost, non-toxic light emitters and photosensitizers.

doi: 10.1038/nature21430


Groundwater depletion embedded in international food trade p.700

Global food consumption drives irrigation for crops, which depletes aquifers in some regions; here we quantify the volumes of groundwater depletion associated with global food production and international trade.

doi: 10.1038/nature21403


Transboundary health impacts of transported global air pollution and international trade p.705

The transboundary health impacts of air pollution associated with the international trade of goods and services are greater than those associated with long-distance atmospheric pollutant transport.

doi: 10.1038/nature21712


The true tempo of evolutionary radiation and decline revealed on the Hawaiian archipelago p.710

A geologically informed model of the relationship between changing island area and species richness for the Hawaiian archipelago reveals the rates of species richness change for 14 endemic groups over their entire evolutionary histories without the need for fossil data or molecular phylogenies.

doi: 10.1038/nature21675


Somatic mutations reveal asymmetric cellular dynamics in the early human embryo p.714

Whole-genome sequencing of normal blood cells sampled from 241 adults is used to infer mosaic point mutations that are likely to have arisen during early embryogenesis, providing insight into how early cellular dynamics may affect adult tissues.

doi: 10.1038/nature21703


Mapping of a non-spatial dimension by the hippocampal–entorhinal circuit p.719

Cells in the hippocampal–entorhinal circuit, which fire in response to navigational variables such as location or speed, are shown also to encode continuous, task-relevant but non-spatial variables such as sound frequency.

doi: 10.1038/nature21692


Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens p.723

Evidence for the abundant presentation of class II neoantigens by a human B-cell lymphoma.

doi: 10.1038/nature21433


Effective combinatorial immunotherapy for castration-resistant prostate cancer p.728

A new chimaeric mouse model of metastatic castration-resistant prostate cancer to efficiently test combination therapies in an autochthonous setting.

doi: 10.1038/nature21676


The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1 p.733

The selective allosteric ABL1 inhibitor ABL001 (asciminib) represents a new inhibitory mechanism for BCR–ABL1-driven malignancies, and its efficacy and evolving mechanisms of resistance do not overlap with those of other BCR–ABL1 kinase inhibitors.

doi: 10.1038/nature21702


Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein p.738

Double electron–electron resonance and computer simulations are used to describe conformational dynamics in the ATP-binding cassette transporter Pgp, which has an important role in the clearance of xenobiotics and cancer resistance to chemotherapy.

doi: 10.1038/nature21414

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