Volume 505 Number 7483



Power to the people p.261

A planned database collating medical information for England’s population is a laudable exercise, with huge potential for research. But people’s right to opt out has been greatly downplayed.

doi: 10.1038/505261a


Cool heads needed p.261

As cold weather rages, it is easy to forget the difference between weather and climate.

doi: 10.1038/505261b


V is for vortex p.262

An endangered species helps scientists to learn why migrating birds fly in a familiar formation.

doi: 10.1038/505262a



Comet craft ready to wake p.269

Stakes high as European Space Agency waits for Rosetta orbiter to come out of hibernation.

doi: 10.1038/505269a


Researchers question rescued polar expedition p.270

Australian Antarctic Division says it did not approve research strategy of stricken mission.

doi: 10.1038/505270a


Repositories share key research tools p.272

But some biological resource centres face funding issues.

doi: 10.1038/505272a


Ampere to get rational redefinition p.273

Single-electron flow measured in bid to overhaul SI base unit.

doi: 10.1038/505273a


Kepler clue to supernova puzzle p.274

Two white dwarfs favoured as precursors of type Ia supernovae.

doi: 10.1038/505274a

News Features


Climate change: The case of the missing heat p.276


doi: 10.1038/505276a


Astrophysics: The heart of darkness p.280


doi: 10.1038/505280a

News & Views


Earth science: River incision revisited p.294


doi: 10.1038/505294a


Bird flight: Fly with a little flap from your friends p.295


doi: 10.1038/505295a


Astrophysics: Black hole found orbiting a fast rotator p.296


doi: 10.1038/505296a


Plant science: Fairy chemicals p.298


doi: 10.1038/505298a

分子生物学:DNA修復 – 押してもだめなら引いてみよう

Molecular biology: The tug of DNA repair p.298


doi: 10.1038/nature12850



CNVs conferring risk of autism or schizophrenia affect cognition in controls p.361

Rare copy-number variants (CNVs) conferring risk of schizophrenia or autism affect fecundity of carriers in Iceland, and carriers of these CNVs who do not suffer disease or have not been diagnosed with intellectual disability show phenotypes in brain structure and cognitive abilities between those of non-carrier controls and patients with schizophrenia.

doi: 10.1038/nature12818


Biochemical reconstitution of topological DNA binding by the cohesin ring p.367

Many DNA processes require chromosomes to be held together by a ring-shaped complex called cohesin, but despite the importance of this protein, its interaction with DNA has not been reproduced in vitro; here, using purified yeast proteins, cohesin loading is successfully recapitulated, offering mechanistic insight into how the loader complex mediates topological cohesin binding.

doi: 10.1038/nature12867


UvrD facilitates DNA repair by pulling RNA polymerase backwards p.372

UvrD acts in nucleotide excision repair by using its helicase/translocase activity to induce RNA polymerase backtracking, enabling repair enzymes to access DNA lesions.

doi: 10.1038/nature12928



A Be-type star with a black-hole companion p.378

A black hole with mass 3.8 to 6.9 times that of the Sun is found to be orbiting the nearby Be-type star MWC 656; the black hole is encircled by an accretion disk and X-ray quiescent, implying that Be binaries with black-hole companions are difficult to detect in conventional X-ray surveys.

doi: 10.1038/nature12916


Nanoparticle solutions as adhesives for gels and biological tissues p.382

Strong, rapid adhesion between two hydrogels and even slices of animal tissue can be achieved at room temperature by using a silica nanoparticle solution as a ‘glue’.

doi: 10.1038/nature12806


Asymmetric synthesis from terminal alkenes by cascades of diboration and cross-coupling p.386

A single-flask, catalytic enantioselective conversion of terminal alkenes into a number of chiral products is described: this tandem diboration/cross-coupling reaction works on a broad range of substrates, requires small amounts of commercially available catalysts, and provides products in high yield and high selectivity.

doi: 10.1038/nature12781


A signature of transience in bedrock river incision rates over timescales of 104–107 years p.391

Rates of river incision into bedrock are thought to reflect rates of rock uplift as well as the strength of climatic forcing of erosion over time, but here incision rate is shown to depend on the measurement interval.

doi: 10.1038/nature12913


Amazon River carbon dioxide outgassing fuelled by wetlands p.395

Global carbon budgets reveal that inland waters emit substantial amounts of carbon, which is believed to originate from the terrestrial biosphere; however, here the carbon emitted from the Amazon River system is shown to originate from temporary wetlands in the flooded area itself, such as flooded forests.

doi: 10.1038/nature12797


Upwash exploitation and downwash avoidance by flap phasing in ibis formation flight p.399

Position and flap phasing between birds in formation flight indicate aerodynamic benefit.

doi: 10.1038/nature12939


A mitochondrial genome sequence of a hominin from Sima de los Huesos p.403

A full mitochondrial genome from a 400,000-year-old Middle Pleistocene hominin from Spain unexpectedly reveals a close relationship to Denisovans, a sister group to the Neanderthals, raising interesting questions about the origins of Neanderthals and Denisovans.

doi: 10.1038/nature12788


Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period p.407

In mice, chronic stimulation by repetitive sounds, whisker deflection, motor activity or seizures during a postnatal developmental critical period, leads to permanent reductions in brain microvascular density, an effect that impairs oxygen delivery to neurons but can be prevented by blocking nitric oxide signalling.

doi: 10.1038/nature12821


Muc5b is required for airway defence p.412

The airway mucin Muc5b (but not Muc5ac) is required for mucociliary clearance, defence against bacterial infection in the airways and middle ear, and maintenance of immune homeostasis in the lungs; Muc5b deficiency causes accumulation of apoptotic macrophages, impairment of phagocytosis and reduced production of interleukin-23, leading to infection and inflammation.

doi: 10.1038/nature12807


Cytokinin signalling inhibitory fields provide robustness to phyllotaxis p.417

The regularly spaced arrangement of plant organs around the stem known as phyllotaxis depends on auxin-based inhibitory fields; this study identifies another hormone-based inhibitory field downstream of auxin which is generated by movement of the cytokinin signalling inhibitor ARABIDOPSIS HISTIDINE PHOSPHOTRANSFER PROTEIN 6 and regulates the periodicity of organ production.

doi: 10.1038/nature12791


Chasing acyl carrier protein through a catalytic cycle of lipid A production p.422

The crystal structures of three forms of Escherichia coli acyl carrier protein engaging LpxD, an acyltransferase in the lipid A biosynthetic pathway, are reported.

doi: 10.1038/nature12679


Trapping the dynamic acyl carrier protein in fatty acid biosynthesis p.427

A highly specific chemical crosslinking method is used to trap a complex between an acyl carrier protein and a fatty acid dehydratase during fatty acid biosynthesis; subsequent X-ray crystallography, NMR spectroscopy and molecular dynamics simulations techniques enable the detailed study of this complex.

doi: 10.1038/nature12810


Icosahedral bacteriophage ΦX174 forms a tail for DNA transport during infection p.432

Here, the atomic structure of a virally encoded, cell-wall-spanning, DNA-translocating conduit from bacteriophage ΦX174 is described.

doi: 10.1038/nature12816

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