Volume 494 Number 7436



Preventive therapy p.147

Stem-cell trials must be made easier, so that treatments can be based on real data.

doi: 10.1038/494147b


A deal on the horizon p.147

Leaders have finally thrashed out the European Union budget for the next seven years. But how much money will go to research is yet to be confirmed.

doi: 10.1038/494147a


Damage control p.148

Planning for extreme events must incorporate not just infrastructure but societal preparedness.

doi: 10.1038/494148a



When Google got flu wrong p.155

US outbreak foxes a leading web-based method for tracking seasonal flu.

doi: 10.1038/494155a


Data barriers limit genetic diagnosis p.156

Tools for data-sharing promise to improve chances of connecting mutations with symptoms of rare diseases.

doi: 10.1038/494156a


Science agencies prepare for cuts p.158

Scientists already feeling the bite of US budget sequester.

doi: 10.1038/494158a


Europe scales back research plans p.159

Leaders propose 13% cut to commission's proposals.

doi: 10.1038/494159a


Malaria drug made in yeast causes market ferment p.160

Synthetic biology delivers combination therapies into an uncertain market.

doi: 10.1038/494160a


Company offers portable peer review p.161

Author-pays service cuts down on redundant reviews.

doi: 10.1038/494161a

News Features

自然災害:ニューヨーク 対 大西洋

Natural hazards: New York vs the sea p.162


doi: 10.1038/494162a


Stem cells in Texas: Cowboy culture p.166


doi: 10.1038/494166a

News & Views


Neuroscience: To go or not to go p.178


doi: 10.1038/nature11856


Asymmetric synthesis: Relay catalysis at a boron centre p.179


doi: 10.1038/494179a


Cell biology: Beneficial lessons from viruses p.181


doi: 10.1038/nature11947


Earth science: All rise for the case of the missing magma p.182


doi: 10.1038/nature11950



Molecular signatures of G-protein-coupled receptors p.185

A systematic investigation of high-resolution G-protein-coupled receptor (GPCR) structures uncovers a conserved inter-helical network of non-covalent contacts that defines the GPCR fold, and provides insights into the molecular determinants of different GPCR conformations.

doi: 10.1038/nature11896



Thin crust as evidence for depleted mantle supporting the Marion Rise p.195

Systematic sampling along the Marion Rise of the Southwest Indian Ridge reveals that its crust is discontinuous and thin, indicating that the rise is supported by low-density depleted mantle beneath it.

doi: 10.1038/nature11842


Identification of a candidate therapeutic autophagy-inducing peptide p.201

A cell-permeable peptide is constructed that is derived from a region of an essential autophagy protein called beclin 1; the peptide is a potent inducer of autophagy in mammalian cells and in vivo in mice, and is effective in the clearance of several viruses.

doi: 10.1038/nature11866



The structure of the asteroid 4 Vesta as revealed by models of planet-scale collisions p.207

Three-dimensional simulations of the global evolution of asteroid 4 Vesta under two overlapping planet-scale collisions closely reproduce its observed shape; but expected large areas of olivine-rich rocks and pure diogenites are not observed on the surface, possibly implying that the outer ~100 km is composed mainly of a basaltic crust (eucrites) with ultramafic intrusions (diogenites).

doi: 10.1038/nature11892


Hybrid circuit cavity quantum electrodynamics with a micromechanical resonator p.211

The properties of a quantum bit coupled to both a microwave cavity and a phonon mode in a micromechanical resonator suggest that such systems may allow for storage of quantum information in long-lived phonon states and read-out via microwave photons, with applications in quantum information control.

doi: 10.1038/nature11821


Simple organic molecules as catalysts for enantioselective synthesis of amines and alcohols p.216

A set of small organic molecules catalyse reactions of unsaturated organoboron reagents with imines and carbonyls to produce amines and alcohols in high enantiomeric purity efficiently, speedily and at low cost through sustainable protocols.

doi: 10.1038/nature11844


Insolation-induced mid-Brunhes transition in Southern Ocean ventilation and deep-ocean temperature p.222

Model simulations show that in response to insolation changes only, southern westerlies and feedbacks between sea ice, temperature, evaporation and salinity caused vigorous Southern Ocean ventilation and cooler deep ocean during the interglacials before the mid-Brunhes transition, suggesting that this transition may in fact have resulted from a series of individual interglacial responses to various combinations of insolation conditions.

doi: 10.1038/nature11790


Vertebral architecture in the earliest stem tetrapods p.226

X-ray synchrotron microtomography has revealed the three-dimensional vertebral architecture of Ichthyostega, and other crucial and celebrated early tetrapods; a surprising feature is the relationship between the vertebral elements, with the pleurocentra unexpectedly attached to the succeeding intercentrum, suggesting a ‘reverse’ rhachitomous design.

doi: 10.1038/nature11825


Biodiversity decreases disease through predictable changes in host community competence p.230

A combination of extensive field surveys and realistic experiments involving an amphibian disease system reveals that biodiversity reduces pathogen transmission due to a predictable link between species richness and the ability of communities to support infection.

doi: 10.1038/nature11883


Finding the sources of missing heritability in a yeast cross p.234

In a cross between two yeast strains, detected loci are found to explain nearly the entire additive contribution to heritable variation for a number of quantitative traits.

doi: 10.1038/nature11867


Concurrent activation of striatal direct and indirect pathways during action initiation p.238

In mice performing an operant task, increases in neural activity in direct- and indirect-pathway spiny projection neurons (SPNs) are associated with action initiation but not with inactivity, and concurrent activation of SPNs from both pathways in one hemisphere precedes the initiation of contraversive movements.

doi: 10.1038/nature11846


A direct and melanopsin-dependent fetal light response regulates mouse eye development p.243

During retinal vascular development there is simultaneous regression of the hyaloid vasculature and formation of the retinal vasculature; here it is demonstrated that regression of developing vasculature is light dependent and acts via the photoreceptor melanopsin.

doi: 10.1038/nature11823

細胞:Wntが促進する再生によって誘導される単一のLgr5+肝幹細胞のin vitroでの増殖

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration p.247

A mouse model of liver damage has identified a population of Lrg5+ liver stem cells that can generate hepatoctyes and bile ducts in vivo.

doi: 10.1038/nature11826


Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance p.251

BRAF inhibitors such as vemurafenib have shown promising effects in patients with BRAF-mutant melanomas, but the tumours generally develop resistance; vemurafenib-resistant melanomas are now shown to be drug dependent, and an intermittent dosing schedule can help prevent drug resistance.

doi: 10.1038/nature11814


Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP p.256

Biguanides such as metformin, which is the most widely prescribed drug for type-2 diabetes, are shown to antagonize the actions of glucagon by decreasing the levels of cyclic AMP.

doi: 10.1038/nature11808


A T-bet gradient controls the fate and function of CCR6RORγt+ innate lymphoid cells p.261

The graded expression of the transcription factor T-bet in CCR6−RORγt+ innate lymphoid cells is found to be involved in the control of interferon-γ expression, a cytokine that is required to protect the epithelial barrier against Salmonella infections.

doi: 10.1038/nature11813


A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis p.266

High-throughput peptide synthesis and mass spectrometry are used to generate a near-complete reference map of the Saccharomyces cerevisiae proteome; two versions of the map (supporting discovery- and hypothesis-driven proteomics) are then applied to a protein-based quantitative trait locus analysis.

doi: 10.1038/nature11835

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