Research press release


Nature Biotechnology

Gauging the behaviour of nanoparticles in the lung


J FrangioniとA Tsudaのグループは、近赤外蛍光画像化法を利用して、ラットの肺に投与したナノ粒子を追跡した。ナノ粒子のどのような性質が、組織内への輸送やその後の体内からのクリアランスに影響するかを知るため、ナノ粒子の化学組成、大きさ、表面電荷をさまざまに変えて調べたところ、正電荷をもたない(non-positively charged)直径34ナノメートル未満の粒子が迅速にリンパ節に運ばれること、正電荷と負電荷を同量もつ直径6ナノメートル未満の粒子が腎臓を経て体内から迅速に排除されることが明らかになった。


The behaviour of nanoparticles in the body after they are deposited in the lungs is reported online in Nature Biotechnology this week. The findings may have implications for future drug delivery, and in the study of air pollution and cancer development.

John Frangioni, Akira Tsuda, and colleagues used near-infrared fluorescent imaging to track nanoparticles administered to the lungs of rats. They varied the chemical composition, size and surface charge of the nanoparticles in order to determine which properties affect the transport of nanoparticles into tissues and their subsequent clearance from the body. The team shows that non-positively charged particles smaller than 34 nanometres in diameter are rapidly transported to lymph nodes, and that nanoparticles smaller than six nanometres with equal positive and negative charge are quickly cleared from the body via the kidneys.

With regard to the health effects of environmental pollutants, this work helps to explain why certain nanoparticles are more toxic than others. It also suggests that the toxicity of nanoparticle pollutants could be reduced by chemical strategies to alter their size and charge.

doi: 10.1038/nbt.1696


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