Research press release



マウスの口腔がん細胞と皮膚がん細胞をパーム油に含まれる食餌脂肪酸に高濃度で曝露 すると、それらの細胞の転移が促進されることを明らかにした論文が、Nature に掲載される。


今回、Salvador Benitahたちは、ヒトの口腔がん細胞と皮膚がん細胞をパルミチン酸(パーム油に含まれる主要な飽和脂肪酸)、オレイン酸、リノール酸という3種類の食餌脂肪酸のいずれかに4日間曝露した後、標準的な食餌を与えたマウスの対応する組織に移植した。調べた脂肪酸はいずれも腫瘍のイニシエーションに影響を及ぼさなかったが、パルミチン酸は、既存の転移病変の浸潤性とサイズの両方を有意に増大させることが分かった。オレイン酸とリノール酸の場合には、そのような有意な効果は認められなかった。



Exposure to high concentrations of a dietary fatty acid contained in palm oil promotes the metastasis of mouth and skin cancer cells in mice, according to a paper published in Nature.

Changes in the uptake and metabolism of fatty acids have been linked to cancer metastasis — the process by which cancer cells spread to other parts of the body. However, it is unclear which dietary fatty acids in particular might be responsible for these changes, and the biological mechanisms involved.

Salvador Benitah and colleagues exposed human mouth and skin cancer cells to one of three types of dietary fatty acid — palmitic acid (the main saturated fatty acid in palm oil), oleic acid or linoleic acid — for four days, before introducing them into corresponding tissues in mice fed a standard diet. Although tumour initiation was not found to be influenced by any of the fatty acids studied, palmitic acid significantly increased both the penetrance and size of existing metastatic lesions. No such significant effect was observed for oleic or linoleic acid.

Pro-metastatic cancer cells also retained ‘memory’ of exposure to high levels of palmitic acid. For example, tumours from mice fed a palm-oil-rich diet for only ten days or tumour cells exposed to palmitic acid in the laboratory transiently for four days (before returning to normal medium) remained highly metastatic even when transplanted into mice fed on a normal diet. This process is associated with epigenetic changes — molecular modifications that alter patterns of gene expression without the DNA itself being altered — in metastatic cells that are suggested to mediate the long-term stimulation of metastasis.

The findings may aid in the identification of new therapies, the authors conclude.

doi: 10.1038/s41586-021-04075-0

「Nature 関連誌注目のハイライト」は、ネイチャー広報部門が報道関係者向けに作成したリリースを翻訳したものです。より正確かつ詳細な情報が必要な場合には、必ず原著論文をご覧ください。

メールマガジンリストの「Nature 関連誌今週のハイライト」にチェックをいれていただきますと、毎週最新のNature 関連誌のハイライトを皆様にお届けいたします。