Research press release





今回、Gou Young Kohたちの研究グループは、マウスの頭蓋底を注意深く調べることで、髄膜リンパ管の正確な位置を可視化し、CSFの取り込みと排出を容易にする特殊な特徴を突き止めた。Kohたちは、若齢マウス(3か月齢)と高齢マウス(24~27か月齢)の髄膜リンパ管の構造と機能を比較することで、リンパ管の完全性とCSFクリアランスが加齢によって低下することを明らかにしている。脳内にタンパク質が蓄積することは、アルツハイマー病などの加齢性神経変性疾患の一因と考えられている。今回の研究によって得られた知見は、神経変性疾患の発症におけるCSFのクリアランス不全の役割に関してさらなる手掛かりをもたらす。

Identification of a precise exit route for fluids leaving the brain, reported in Nature this week, helps us to understand how waste is cleared from the brain. The findings also shed light on how age-related changes in this process may affect the development of neurodegenerative diseases.

Excess fluids and large molecules (such as proteins) are removed from tissues via lymphatic vessels, although the brain was thought to lack a classical lymphatic drainage system until recently. Around four years ago a network of vessels (meningeal lymphatic vessels) in the outer brain membrane were rediscovered and found to regulate fluid balance by draining it of macromolecules. The precise route of cerebrospinal fluid (CSF) drainage remained unclear, however, in part due to difficulties in exploring a subset of these vessels trapped within complex structures at the base of the skull.

By performing careful examination of the skull base in mice, Gou Young Koh and colleagues visualize the precise location of basal meningeal lymphatic vessels and identify specialized features that facilitate CSF uptake and drainage. The authors compared meningeal lymphatic vessel structure and function in young (3 months old) and aged (24 - 27 months old) mice, uncovering an age-related decline in the vessel integrity and CSF clearance. A build-up of proteins in the brain is thought to contribute to age-related neurodegenerative diseases, such as Alzheimer’s disease. The latest findings provide further insights into the role of impaired CSF clearance in the development of neurodegenerative diseases.

doi: 10.1038/s41586-019-1419-5

「Nature 関連誌注目のハイライト」は、ネイチャー広報部門が報道関係者向けに作成したリリースを翻訳したものです。より正確かつ詳細な情報が必要な場合には、必ず原著論文をご覧ください。

メールマガジンリストの「Nature 関連誌今週のハイライト」にチェックをいれていただきますと、毎週最新のNature 関連誌のハイライトを皆様にお届けいたします。