Research press release





今回、Philippe Mourrainたちの研究グループは、2週齢のゼブラフィッシュ幼生の睡眠時の眼球運動、筋肉運動、心拍とともに脳全体の活動を測定し、この測定結果を用いて、ゼブラフィッシュの睡眠のニューロンのシグネチャーを初めて突き止めた。今回の研究では、さまざまな睡眠状態[徐バースト型睡眠(SBS)、深睡眠、レム睡眠など]を心筋や眼筋などの筋肉に特有のシグネチャーと結び付けて明らかにしている。Mourrainたちは、これらの知見が、脊椎動物全体にとって必須の祖先型の睡眠機能を示している可能性があると考えている。

Zebrafish experience similar sleep stages as mammals, birds and reptiles, according to a paper published this week in Nature. These findings suggest that sleep as humans experience it may have emerged as far back as 450 million years ago.

Sleep has been described in all branches of the animal kingdom using behavioural criteria and, in the case of humans, the main electrophysiological hallmarks have been identified: deep and rapid eye movement (REM) sleep. These sleep states have also been found in other mammals, birds and reptiles, but it has remained unclear whether fish and amphibians, earlier common ancestors of humans, experience these same states.

Philippe Mourrain and colleagues measured brain-wide activity along with eye movement, muscle dynamics and heart rate of two-week-old zebrafish larvae during sleep. Using these measurements, the authors were able to identify the first neuronal sleep signatures in this type of fish. They identified various sleep states - including slow-bursting, deep sleep and REM - coupled with characteristic muscle signatures, including in the heart and eye. The authors suggest that these findings are likely to mark ancestral sleep functions that are essential across vertebrates.

doi: 10.1038/s41586-019-1336-7

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