Research press release




Tony Wyss-Corayたちの研究グループは、これまでの研究で、若齢マウスの血中因子を使うと老齢マウスにおける老化に伴う変化を阻害できることを明らかにしていた。今回、この研究グループは、これに似た効果がヒトの臍帯血漿にあることを実証し、この効果の原因としてTIMP2(組織メタロプロテアーゼ阻害物質2)というタンパク質を同定した。


A protein present in human umbilical cord plasma can revitalize the hippocampus and improve cognitive function in aged mice, reveals a Nature paper published online this week. The discovery could potentially aid the development of therapies to target degeneration in the ageing brain.

Tony Wyss-Coray and colleagues have previously shown that blood-borne factors in young mice can counteract age-related changes in older mice. Here, the authors demonstrate a similar effect for human cord plasma and identify a protein called tissue inhibitor of metalloproteinases 2 (TIMP2) that is responsible for the effect.

The protein, which occurs naturally during early development, appeared in the brain after injection into aged mice. Following treatment, aged mice improved in various tests of learning, memory and synaptic plasticity (the brain’s ability to change and adapt to new information). Together, the findings suggests that systemic factors present early in life could help to revitalize aged tissue, and that TIMP2 and/or the cells targeted by it could be useful targets for drug development.

doi: 10.1038/nature22067

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