US foreign aid saves money as well as lives p.269

Cutting the budget for applied research in foreign aid would make the United States less competitive.

doi: 10.1038/nature.2017.21826

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French scientists focus on the big political picture p.269

Researchers in France overwhelmingly oppose the far right and can stamp out its rise by turning out to register their disapproval.

doi: 10.1038/544269a

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Social networks push runners to run further and faster than their friends p.270

Online data sharing through wearable devices motivates people to do more exercise.

doi: 10.1038/544270a

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French-election fears unite scientists in defence of liberal democracy p.277

Threat of a far-right president galvanizes researchers to put politics first.

doi: 10.1038/544277a

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Drivers gear up for world’s first nanocar race p.278

Chemists will navigate molecular wagons along a tiny golden track.

doi: 10.1038/544278a

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Unravelling why shoelace knots fail p.279

A better understanding of this pedestrian problem could lead to improved surgeons’ knots and fibres.

doi: 10.1038/nature.2017.21815

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Republican scientists negotiate the Trump era p.280

Conservative academics face a growing tension between their politics and the liberal atmosphere on many US campuses.

doi: 10.1038/544280a

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Global coalition chips away at neglected tropical diseases p.281

Partnerships see some success in eliminating illnesses, but challenges, such as access to treatments, remain.

doi: 10.1038/544281a

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News Features


DNA's secret weapon against knots and tangles p.284


doi: 10.1038/544284a

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News & Views


Ecology: In peril from a perfect pathogen p.300


doi: 10.1038/544300a

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Materials science: Crystals aligned through graphene p.301


doi: 10.1038/544301a

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Neurodegenerative Disease: Two–for–one on potential therapies p.302


doi: 10.1038/nature21911

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Microbiology: Gut microbes augment neurodegeneration p.304


doi: 10.1038/nature21910

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Materials science: How to print glass p.305


doi: 10.1038/544305a

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Glaciology: Ice-shelf stability questioned p.306


doi: 10.1038/544306a

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Structural biology: A receptor that might block itself p.307


doi: 10.1038/nature21907

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Virus genomes reveal factors that spread and sustained the Ebola epidemic p.309

Frequent dispersal and short-lived local transmission clusters fuelled the 2013–2016 Ebola virus epidemic in Guinea, Liberia and Sierra Leone.

doi: 10.1038/nature22040

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Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP p.316

Postsynaptic synaptotagmin-1 and synaptotagmin-7 mediate calcium-dependent exocytosis of AMPA receptors during long-term potentiation.

doi: 10.1038/nature21720

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A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis p.322

The biosynthesis of oxetanocin A involves OxsB, a B12-dependent S-adenosylmethionine radical enzyme, which catalyses an unusual ring contraction of a 2′-deoxyadenosine phosphate.

doi: 10.1038/nature21689

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Structural basis for selectivity and diversity in angiotensin II receptors p.327

Crystal structures of two complexes of the angiotensin II receptor AT2R with distinct tightly bound ligands reveal an active-like state of the receptor, in which helix VIII adopts a non-canonical position that blocks binding of G proteins and β-arrestins.

doi: 10.1038/nature22035

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A temperate rocky super-Earth transiting a nearby cool star p.333

An Earth-sized planet is observed orbiting a nearby star within the liquid-water, habitable zone, the atmospheric composition of which could be determined from future observations.

doi: 10.1038/nature22055

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Three-dimensional printing of transparent fused silica glass p.337

Using stereolithography 3D printers, a silica nanocomposite is shaped and then fused to produce non-porous, very smooth, highly transparent fused silica glass components.

doi: 10.1038/nature22061

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Remote epitaxy through graphene enables two-dimensional material-based layer transfer p.340

Conventional epitaxy is of limited application, but by placing a monolayer of graphene between the substrate and the so-called epilayer grown on top, its scope can be substantially extended.

doi: 10.1038/nature22053

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Antarctic ice shelf potentially stabilized by export of meltwater in surface river p.344

On the Nansen Ice Shelf in Antarctica, a surface river that terminates in a waterfall can drain the ice shelf’s entire annual meltwater in just one week, potentially preventing the meltwater from hastening the catastrophic collapse of the shelf.

doi: 10.1038/nature22048

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Widespread movement of meltwater onto and across Antarctic ice shelves p.349

Surface water and its drainage across the surface of Antarctic ice is shown to be widespread, large-scale and to have persisted for decades.

doi: 10.1038/nature22049

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Drivers of salamander extirpation mediated by Batrachochytrium salamandrivorans p.353

The authors investigated the disease ecology of the fast-spreading fungal pathogen Batrachochytrium salamandrivorans in fire salamanders; on the basis of their research, they call for Europe-wide monitoring systems and conservation strategies for threatened species.

doi: 10.1038/nature22059

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Neanderthal behaviour, diet, and disease inferred from ancient DNA in dental calculus p.357

Analysis of calcified dental plaque (calculus) specimens from Neanderthals shows marked regional differences in diet and microbiota and evidence of self-medication in one individual, and identifies prevalent microorganisms and their divergence between Neanderthals and modern humans.

doi: 10.1038/nature21674

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Antisense oligonucleotide therapy for spinocerebellar ataxia type 2 p.362

Antisense oligonucleotides against ATXN2 improved motor neuron function and restored firing frequency in cerebellar Purkinje cells in mouse models of spinocerebellar ataxia type 2.

doi: 10.1038/nature22044

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Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice p.367

A decrease in ataxin-2 levels leads to a reduction in the aggregation of TDP-43, markedly increased lifespan and improved motor function in a transgenic mouse model of TDP-43 proteinopathy.

doi: 10.1038/nature22038

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Modulating the therapeutic response of tumours to dietary serine and glycine starvation p.372

Dependence on exogenous serine means that tumour growth is restricted in mice on a low-serine diet; this effect on tumour growth can be amplified by antagonizing the antioxidant response.

doi: 10.1038/nature22056

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Rad51-mediated double-strand break repair and mismatch correction of divergent substrates p.377

DNA repair by break-induced replication begins with the Rad51-mediated invasion of single-stranded DNA into a double-stranded donor template; this study shows that successful recombination between highly mismatched substrates can occur when only five consecutive bases can be paired and that mismatch correction is most efficient near the invading end of the recipient strand.

doi: 10.1038/nature22046

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