Volume 544 Number 7651



More surgeons must start doing basic science p.393

They say they don't have the time or incentives to do research — and that’s dangerous for translational medicine.

doi: 10.1038/544393b


Liquid-biopsies success highlights power of combining basic and clinical research p.393

Using free-floating DNA to detect lung cancer brings benefits to researchers and patients alike.

doi: 10.1038/544393a


Announcement: Nature journals support the San Francisco Declaration on Research Assessment p.394

doi: 10.1038/nature.2017.21882



California’s $3-billion bet on stem cells faces final test p.401

Major investment in regenerative medicine enters its last stage — and the money might run out before treatments are ready.

doi: 10.1038/544401a


Ripple effects of New Zealand earthquake continue to this day p.402

November tremor sparked slow, deep movements in Earth’s crust that increase the chances of a similar severe quake within a year.

doi: 10.1038/nature.2017.21876


Mining threatens Chinese fossil site that revealed planet's earliest animals p.403

Protests sparked by the destruction of three key fossil-hunting areas result in a temporary halt of phosphate mining.

doi: 10.1038/nature.2017.21869


What happened at March for Science events around the world p.404

Nature reported from marches in cities including Sydney, Washington DC and Paris, as people took to the streets in support of science.

doi: 10.1038/nature.2017.21853


Surprise El Niño causes devastation but offers lessons for ecologists p.405

How Peruvian coastal deserts respond to rains will aid future disaster response.

doi: 10.1038/544405a

News Features


The next big hit in molecule Hollywood p.408


doi: 10.1038/544408a

News & Views


Animal behaviour: How to build a better dad p.418


doi: 10.1038/nature22486


Particle physics: Strangeness in the proton p.419


doi: 10.1038/nature21909


Archaeology: Unexpectedly early signs of Americans p.420


doi: 10.1038/544420a


Atmospheric science: Severe weather in a warming climate p.422


doi: 10.1038/544422a


Microscopy: A larger palette for biological imaging p.423


doi: 10.1038/544423a


Plant science: Genomic compartments in barley p.424


doi: 10.1038/544424a



A chromosome conformation capture ordered sequence of the barley genome OPEN p.427

The International Barley Genome Sequencing Consortium reports sequencing and assembly of a reference genome for barley, Hordeum vulgare.

doi: 10.1038/nature22043


The genetic basis of parental care evolution in monogamous mice p.434

Parental care in mice evolves through multiple genetic changes; one candidate is vasopressin, the reduced expression of which promotes parental nest-building behaviour in monogamous mice.

doi: 10.1038/nature22074


Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure p.440

The cryo-electron microscopy structure of Saccharomyces cerevisiae Snf2 chromatin remodeller bound to a nucleosome and a proposed mechanism for DNA translocation by Snf2 are presented.

doi: 10.1038/nature22036


Structure and allosteric inhibition of excitatory amino acid transporter 1 p.446

High-resolution structures of the thermostabilized human excitatory amino acid transporter EAAT1, alone or in association with its substrate or small molecule inhibitors, reveal architectural features of human SLC1 transporters and an allosteric mechanism of inhibition.

doi: 10.1038/nature22064



A universal model for solar eruptions p.452

Simulations of a solar coronal jet driven by filament ejection demonstrate that magnetic reconnection underlies the energy release, implying that a universal ‘breakout’ model explains both tiny jets and huge mass ejections from the Sun.

doi: 10.1038/nature22050


Predicting crystal growth via a unified kinetic three-dimensional partition model p.456

A general simulation approach that can replicate, and in theory predict, the growth of a wide range of crystal types, including porous, molecular and ionic crystals, is demonstrated.

doi: 10.1038/nature21684


Ultrastrong steel via minimal lattice misfit and high-density nanoprecipitation p.460

A method of producing superstrong yet ductile steels using cheaper and lighter alloying elements is described, based on minimization of the lattice misfit to achieve a maximal dispersion of nanoprecipitates, leading to ultimate precipitation strengthening.

doi: 10.1038/nature22032


Super-multiplex vibrational imaging p.465

Stimulated Raman scattering under electronic pre-resonance conditions, combined with a new palette of probes, enables super-multiplex imaging of molecular targets in living cells with very high vibrational selectivity and sensitivity.

doi: 10.1038/nature22051


Abrasion-set limits on Himalayan gravel flux p.471

The amount of coarse gravel transported out of the Himalayan mountains by rivers is insensitive to catchment size, because the majority of gravel sourced more than 100 kilometres upstream of the mountain front is abraded into sand before it reaches the Ganga Plain.

doi: 10.1038/nature22039


Frequency of extreme Sahelian storms tripled since 1982 in satellite observations p.475

Since 1982, extreme daily rainfall in the western Sahel has increased persistently, owing to a warmer Sahara which has led to increased wind shear and an increase in intense storms.

doi: 10.1038/nature22069


A 130,000-year-old archaeological site in southern California, USA p.479

Evidence of mastodon bone modifications for marrow extraction and/or tool production, found in the presence of hammerstones and anvils that showed use-wear and impact marks, suggest the presence of Homo in North America around 130 thousand years ago.

doi: 10.1038/nature22065


The earliest bird-line archosaurs and the assembly of the dinosaur body plan p.484

The archosaur species Teleocrater rhadinus, part of the new clade Aphanosauria, is an example of the earliest divergence of the avian stem lineage (Avemetatarsalia), the lineage that contains dinosaurs (including birds).

doi: 10.1038/nature22037


Human umbilical cord plasma proteins revitalize hippocampal function in aged mice p.488

Treatment with plasma of an early developmental stage, human umbilical cord, revitalizes the hippocampus and improves cognitive function in aged mice.

doi: 10.1038/nature22067


SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin p.493

The identification of homotypic SLAMF7 interactions responsible for haematopoietic tumour cell phagocytosis by macrophages when the inhibitory receptor/ligand interaction of SIRPα/CD47 is blocked therapeutically.

doi: 10.1038/nature22076


High-avidity IgA protects the intestine by enchaining growing bacteria p.498

doi: 10.1038/nature22058


Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl p.503

The distribution of cohesin in the mouse genome depends on CTCF, transcription and the cohesin release factor Wapl.

doi: 10.1038/nature22063

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