No time to chop funding for a pivotal climate programme p.287

As the Great Barrier Reef suffers yet more potentially fatal damage, it makes no sense to chop funds from a global progamme that analyses the threats of a changing climate

doi: 10.1038/543287a

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Springer Natureは、発行する全ての学術誌で、研究の再現性・信頼性を高めるため、透明性基準を強化する。

Announcement: Transparency upgrade for Nature journals p.288

The Nature journals continue journey towards greater rigour.

doi: 10.1038/543288b

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Not just dwingey chimbles: dialects are alive and kicking p.288

A British Library collection of regional words and phrases shows that language is still evolving.

doi: 10.1038/543288a

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Earth’s lost history of planet-altering eruptions revealed p.295

Geologists unearth signs of major volcanic events stretching back 3 billion years.

doi: 10.1038/543295a

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‘Zombie’ patent fights over mutant mice return p.296

University takes on US National Institutes of Health over animals used for Alzheimer’s research.

doi: 10.1038/nature.2017.21620

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First fluorescent frog found p.297

A rare find in land animals reveals a new way to glow.

doi: 10.1038/nature.2017.21616

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Synthetic yeast chromosomes help probe mysteries of evolution p.298

To work out how the yeast genome evolved, bioengineers are recreating it.

doi: 10.1038/nature.2017.21615

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New England Journal of Medicineのある掲載論文の臨床試験データを題材にした、データ解析コンテストの結果発表が。

Open-data contest unearths scientific gems — and controversy p.299

Hundreds of researchers pick through clinical trial from a major blood-pressure study, to the dismay of some who collected the information.

doi: 10.1038/nature.2017.21572

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Chinese mountain observatory to probe cosmic-ray origins p.300

The massive project will intercept γ-ray showers in an unexplored energy band.

doi: 10.1038/543300a

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News Features


CRISPR, microbes and more are joining the war against crop killers p.302


doi: 10.1038/543302a

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A makeover for the world's most hated crop p.306


doi: 10.1038/543306a

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News & Views


Astrophysics: Distant galaxies lack dark matter p.318


doi: 10.1038/543318a

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Biomedicine: An improved gel for detached retinas p.319


doi: 10.1038/nature21898

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Physiology: Bone-derived hormone suppresses appetite p.320


doi: 10.1038/nature21501

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Biogeochemistry: A plan for efficient use of nitrogen fertilizers p.322


doi: 10.1038/543322a

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Ecology: Coral crisis captured p.323


doi: 10.1038/543323a

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Cell biology: Sort and destroy p.324


doi: 10.1038/nature21892

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Applied physics: 3D imaging for microchips p.325


doi: 10.1038/543325a

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Molecular biology: A hidden competitive advantage of disorder p.325


doi: 10.1038/nature21893

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Mineral supply for sustainable development requires resource governance p.367

doi: 10.1038/nature21359

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Global warming and recurrent mass bleaching of corals p.373

Aerial and underwater survey data combined with satellite-derived measurements of sea surface temperature over the past two decades show that multiple mass-bleaching events have expanded to encompass virtually all of the Great Barrier Reef.

doi: 10.1038/nature21707

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Integrated genomic and molecular characterization of cervical cancer p.378

This paper describes molecular subtypes of cervical cancers, including squamous cell carcinoma and adenocarcinoma clusters defined by HPV status and molecular features, and distinct molecular pathways that are activated in cervical carcinomas caused by different somatic alterations and HPV types.

doi: 10.1038/nature21386

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MC4R-dependent suppression of appetite by bone-derived lipocalin 2 p.385

Osteoblast-derived LCN2 activates the melanocortin 4 receptor in neurons of the paraventricular nucleus of the hypothalamus to suppress appetite, regulates insulin secretion and increases insulin sensitivity and glucose tolerance.

doi: 10.1038/nature21697

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Molecular basis of ancestral vertebrate electroreception p.391

Detection of weak electrical signals by skates relies on functional coupling of specific calcium and potassium channels, which mediates oscillations in electrosensory cell membrane voltage.

doi: 10.1038/nature21401

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Strongly baryon-dominated disk galaxies at the peak of galaxy formation ten billion years ago p.397

The rotation velocities in the outer disks of six massive star-forming galaxies are shown to decrease with disk radius, owing to high baryonic mass fractions and large velocity dispersions.

doi: 10.1038/nature21685

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High-resolution non-destructive three-dimensional imaging of integrated circuits p.402

A recently developed computational imaging technique, X-ray ptychographic tomography, is used to study integrated circuits, and a 3D image of a processor chip with a resolution of 14.6 nm is obtained.

doi: 10.1038/nature21698

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Enzymatic mineralization generates ultrastiff and tough hydrogels with tunable mechanics p.407

Synthetic hydrogels are here created by enzyme-induced mineralization of hydrogel networks, yielding materials that are tough yet impressively stiff, with calcium phosphate particles distributed homogeneously throughout the network.

doi: 10.1038/nature21392

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Biofuel blending reduces particle emissions from aircraft engines at cruise conditions p.411

Compared to using conventional jet fuel, the use of a biofuel blend reduces aircraft engine particle emissions at cruising altitude by about 50–70 per cent.

doi: 10.1038/nature21420

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Rheological separation of the megathrust seismogenic zone and episodic tremor and slip p.416

A model of the conditions required for episodic tremor and accompanying slow slip to occur, near the megathrust seismogenic zone, reconciles seemingly contradictory observations.

doi: 10.1038/nature21389

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Paleoproterozoic sterol biosynthesis and the rise of oxygen p.420

Steranes in ancient rocks have been used as ‘molecular fossils’, but the very earliest records of steranes have been shown to be contaminants; here, the presence of two key sterol biosynthesis enzymes in eukaryotes and bacteria suggests at least one gene transfer between bacteria and the earliest eukaryotes occurred some 2.3 billion years ago.

doi: 10.1038/nature21412

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Interplay between metabolic identities in the intestinal crypt supports stem cell function p.424

The glycolytic activity of Paneth cells provides lactate, which is required by self-renewing intestinal stem cells for oxidative metabolism to activate p38 MAP kinase, ensuring regeneration of a mature crypt.

doi: 10.1038/nature21673

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がん:クラスIIa HDACの阻害は抗腫瘍マクロファージを介して乳がんを縮小させ転移を減らす

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages p.428

A selective class IIa histone deacetylase inhibitor induces anti-tumour immunity in a mouse model of mammary cancer through altered differentiation and recruitment of tumour-associated macrophages.

doi: 10.1038/nature21409

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SZT2 dictates GATOR control of mTORC1 signalling p.433

SZT2 recruits GATOR1 and GATOR2 to form a SZT2-orchestrated GATOR (SOG) complex at the lysosome that is essential for GATOR- and SESN-dependent nutrient sensing and mTORC1 regulation.

doi: 10.1038/nature21378

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KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1 p.438

A protein complex composed of KPTN, ITFG2, C12orf66 and SZT2, named KICSTOR, is necessary for lysosomal localization of GATOR1, interaction of GATOR1 with the Rag GTPases and GATOR2, and nutrient-dependent mTORC1 modulation.

doi: 10.1038/nature21423

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Cytosolic proteostasis through importing of misfolded proteins into mitochondria p.443

Proteins prone to aggregation in yeast are imported into mitochondria under stress conditions, suggesting that mitochondrial import and proteolysis may help to disaggregate proteins in the cytoplasm.

doi: 10.1038/nature21695

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Hypersensitive termination of the hypoxic response by a disordered protein switch p.447

The intrinsically disordered CITED2 negative feedback regulator displaces the tightly bound hypoxia-inducible transcription factor HIF-1α from their common target TAZ1 through the formation of an intermediate ternary complex and thereby attenuates the hypoxic response.

doi: 10.1038/nature21705

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