Dutch elections signal next test for rise in populism p.149

Science is already losing out in the Netherlands.

doi: 10.1038/543149b

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Rising to the challenge as US states turn the screw on science education p.149

Researchers everywhere should pay more attention to how their subject is presented.

doi: 10.1038/543149a

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Science journalism can be evidence-based, compelling — and wrong p.150

A ranking of the best science-news outlets misjudges the relationship between research and reporting.

doi: 10.1038/543150a

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How the fallout from Trump's travel ban is reshaping science p.157

Researchers are cutting short travel, ending collaborations and rethinking their US ties.

doi: 10.1038/nature.2017.21579

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IBMが、量子コンピューターの市場形成を目指してクラウドサービス「IBM Q」を発表。

IBM's quantum cloud computer goes commercial p.159

Company plans a bigger, better system aimed at creating a market for the still-immature technology.

doi: 10.1038/nature.2017.21585

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How rival bots battled their way to poker supremacy p.160

Artificial-intelligence programs harness game-theory strategies and deep learning to defeat human professionals in two-player hold 'em.

doi: 10.1038/nature.2017.21580

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Peer-review activists push psychology journals towards open data p.161

Editor asked to resign from journal for saying he’ll review only papers whose data he can see.

doi: 10.1038/nature.2017.21549

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Quantum microscope offers MRI for molecules p.162

Diamond-based imaging system uses magnetic resonance of electrons to detect charged atoms and peer at chemical reactions in real time.

doi: 10.1038/nature.2017.21573

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Neanderthal tooth plaque hints at meals — and kisses p.163

Analysis paints picture of diets, medicine and possible intimacy with humans.

doi: 10.1038/543163a

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News Features


The quest to crystallize time p.164


doi: 10.1038/543164a

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How Facebook, fake news and friends are warping your memory p.168


doi: 10.1038/543168a

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News & Views


Microbiology: Manipulation of the manipulators p.182


doi: 10.1038/nature21509

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Non-coding RNA: More uses for genomic junk p.183


doi: 10.1038/543183a

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Condensed-matter physics: Marching to a different quantum beat p.185


doi: 10.1038/543185a

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Cancer epigenetics: Reading the future of leukaemia p.186


doi: 10.1038/nature21894

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Archaeology: Digital maps illuminate ancient trade routes p.188


doi: 10.1038/543188a

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Nanoscience: Single-atom data storage p.189


doi: 10.1038/543189a

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Immunology: The chronicles of T-cell exhaustion p.190


doi: 10.1038/nature21508

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Nomadic ecology shaped the highland geography of Asia’s Silk Roads p.193

The authors use modelling to show that the network of trading routes known as the Silk Road emerged from hundreds of years of interactions between pastoralists as they moved their herds and flocks between higher and lower elevations in generally mountainous regions.

doi: 10.1038/nature21696

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An atlas of human long non-coding RNAs with accurate 5′ ends p.199

A catalogue of human long non-coding RNA genes and their expression profiles across samples from major human primary cell types, tissues and cell lines.

doi: 10.1038/nature21374

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Autophagy maintains the metabolism and function of young and old stem cells p.205

Loss of autophagy increases the accumulation of mitochondria and the respiration status of haematopoietic stem cells, which perturbs their self-renewal and regeneration activities, and promotes cellular aging.

doi: 10.1038/nature21388

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TIRR regulates 53BP1 by masking its histone methyl-lysine binding function p.211

A new protein, Tudor interacting repair regulator (TIRR), affects DNA repair by masking the chromatin interaction domain of 53BP1, thereby preventing its recruitment to double-strand breaks.

doi: 10.1038/nature21358

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Observation of a discrete time crystal p.217

A time crystal is a state of matter that shows robust oscillations in time, and although forbidden in equilibrium, a discrete time crystal has now been observed in a periodically driven quantum system.

doi: 10.1038/nature21413

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Observation of discrete time-crystalline order in a disordered dipolar many-body system p.221

Discrete time-crystalline order is observed in a driven, disordered ensemble of about one million dipolar spin impurities in diamond at room temperature, and is shown to be very stable to perturbations.

doi: 10.1038/nature21426

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Reading and writing single-atom magnets p.226

A two-bit magnetic memory is demonstrated, based on the magnetic states of individual holmium atoms, which are read and written in a scanning tunnelling microscope set-up and are stable over many hours.

doi: 10.1038/nature21371

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Amplified stimulated emission in upconversion nanoparticles for super-resolution nanoscopy p.229

Super-resolution optical microscopy based on stimulated emission depletion effects can now be performed at much lower light intensities than before by using bright upconversion emission from thulium-doped nanoparticles.

doi: 10.1038/nature21366

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Arrays of horizontal carbon nanotubes of controlled chirality grown using designed catalysts p.234

Horizontal arrays of metallic or semiconducting carbon nanotubes with controlled chirality are grown from specially designed solid carbide catalysts.

doi: 10.1038/nature21051

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Earth’s first stable continents did not form by subduction p.239

Phase equilibria modelling of rocks from Western Australia confirms that the ancient continental crust could have formed by multistage melting of basaltic ‘parents’ along high geothermal gradients—a process incompatible with modern-style subduction.

doi: 10.1038/nature21383

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Prophage WO genes recapitulate and enhance Wolbachia-induced cytoplasmic incompatibility p.243

The discovery of two genes encoded by prophage WO from Wolbachia that functionally recapitulate and enhance cytoplasmic incompatibility in arthropods is the first inroad in solving the genetic basis of reproductive parasitism.

doi: 10.1038/nature21391

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Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination p.248

A single, low-dose intradermal immunization with lipid-nanoparticle-encapsulated nucleoside-modified mRNA encoding the pre-membrane and envelope glycoproteins of Zika virus protects both mice and rhesus macaques against infection and elicits rapid and long-lasting neutralizing antibody responses.

doi: 10.1038/nature21428

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Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism p.252

FABP4 and FABP5 are important for the maintenance, longevity and function of CD8+ tissue-resident memory T cells, which use oxidative metabolism of exogenous free fatty acids to persist in tissues and to mediate protective immunity.

doi: 10.1038/nature21379

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Reconstitution of the tubular endoplasmic reticulum network with purified components p.257

In the presence of GTP, a tubular endoplasmic reticulum network can be reconstituted with only two purified membrane proteins.

doi: 10.1038/nature21387

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The molecular architecture of lamins in somatic cells p.261

Cryo-electron tomography reveals a detailed view of the structural organization of the lamin meshwork within the lamina of the mammalian cell nucleus.

doi: 10.1038/nature21382

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ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia p.265

The chromatin-reader protein ENL regulates oncogenic programs in acute myeloid leukaemia by binding via its YEATS domain to acetylated histones on the promoters of actively transcribed genes and recruiting the transcriptional machinery.

doi: 10.1038/nature21687

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がんエピジェネティクス:急性白血病におけるENL YEATSドメインによる転写制御

Transcription control by the ENL YEATS domain in acute leukaemia p.270

ENL, identified in a genome-scale loss-of-function screen as a crucial requirement for proliferation of acute leukaemia, is required for leukaemic gene expression, and its YEATS chromatin-reader domain is essential for leukaemic growth.

doi: 10.1038/nature21688

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