Volume 541 Number 7636



Fantasy politics p.133

A US congressional investigation has distorted the truth about research that uses human fetal tissue — and sets a troubling precedent.

doi: 10.1038/541133a


‘Nature-based solutions’ is the latest green jargon that means more than you might think p.133

It may sound vague, but the term represents real and vital concepts.

doi: 10.1038/541133b

2017年、Nature Researchは、Nature AstronomyNature Ecology & EvolutionNature Biomedical EngineeringNature Human BehaviourNature Reviews Chemistryの5誌を創刊する。

Announcement: Nature launches five new journals for 2017 p.134

doi: 10.1038/541134a



Chinese AI company plans to mine health data faster than rivals p.141

iCarbonX believes its cutting-edge partners and generous funding give it the upper hand.

doi: 10.1038/541141a


Google reveals secret test of AI bot to beat top Go players p.142

Updated version of DeepMind's AlphaGo program behind mystery online competitor.

doi: 10.1038/nature.2017.21253


Legendary radio telescope hangs in the balance p.143

US National Science Foundation looks to slash funding for Puerto Rico’s Arecibo Observatory.

doi: 10.1038/541143a


Deceptive curcumin offers cautionary tale for chemists p.144

Spice extract dupes assays and leads some drug hunters astray.

doi: 10.1038/541144a


Brexit offers rare chance to make Britain greener p.145

Environmental scientists plan to push for policy changes but are nervous about losing current protections.

doi: 10.1038/541145a


Gene-edited cows, rogue clinics, speedier drug approvals: the challenges facing Trump's FDA chief p.146

The agency's next leader will have an opportunity to reshape its approach to regulation.

doi: 10.1038/nature.2017.21256

News Features


Behind New Zealand’s wild plan to purge all pests p.148


doi: 10.1038/541148a

News & Views


Biological techniques: Stomach growth in a dish p.160

胃の主要部分に似た構造をヒト胚性幹細胞からin vitroで成長させるプロトコルが開発された。これは、胃の発生に関する知見が得られる進歩である。

doi: 10.1038/nature21110


Fluid dynamics: Water flows out of touch p.161


doi: 10.1038/541161a


Cancer genomics: Spot the difference p.162


doi: 10.1038/nature21112


Optical physics: Supercavity lasing p.164


doi: 10.1038/541164a


Physiology: Mechanosensor of lung inflation identified p.165


doi: 10.1038/nature21111


Stem cells: Valine starvation leads to a hungry niche p.166


doi: 10.1038/nature21106


Climate science: The resilience of Amazonian forests p.167


doi: 10.1038/541167a



Integrated genomic characterization of oesophageal carcinoma OPEN p.169

The Cancer Genome Atlas Research Network report integrated genomic and molecular analyses of 164 squamous cell carcinomas and adenocarcinomas of the oesophagus; they find genomic and molecular features that differentiate squamous and adenocarcinomas of the oesophagus, and strong similarities between oesophageal adenocarcinomas and the chromosomally unstable variant of gastric adenocarcinoma, suggesting that gastroesophageal adenocarcinoma is a single disease entity.

doi: 10.1038/nature20805


Piezo2 senses airway stretch and mediates lung inflation-induced apnoea p.176

The mechanoreceptor Piezo2 is required for both the Hering–Breuer inflation reflex in adult mice and the inflation of the lungs of newborn mice.

doi: 10.1038/nature20793


Wnt/β-catenin promotes gastric fundus specification in mice and humans p.182

Wnt signalling is shown to be required for specification of the gastric fundus in mice, and was used to develop human gastric organoids with functional fundic cell types.

doi: 10.1038/nature21021



Penitentes as the origin of the bladed terrain of Tartarus Dorsa on Pluto p.188

Simulations of Pluto suggest that the sharp ridges in the Tartarus Dorsa region of Pluto are penitentes that formed over the past tens of millions of years.

doi: 10.1038/nature20779


Sideband cooling beyond the quantum backaction limit with squeezed light p.191

Squeezed light is used to sideband cool the motion of a macroscopic mechanical object below the limit imposed by quantum fluctuations.

doi: 10.1038/nature20604


Lasing action from photonic bound states in continuum p.196

Lasing action from an optically pumped bound state in the continuum cavity is demonstrated, of both fundamental interest and with applications from optical trapping to biological sensing and quantum information.

doi: 10.1038/nature20799


Aromatic and antiaromatic ring currents in a molecular nanoring p.200

By investigating ring currents, a six-porphyrin nanoring molecule is shown to be antiaromatic in its 4+ oxidation state and aromatic in its 6+ oxidation state.

doi: 10.1038/nature20798


Hydroclimate changes across the Amazon lowlands over the past 45,000 years p.204

Oxygen isotope records derived from stalagmites in the eastern Amazon reveal that rainfall was about half of today’s during the Last Glacial Maximum but half again as much during the mid-Holocene, broadly coinciding with global changes in temperature and carbon dioxide.

doi: 10.1038/nature20787


A symmoriiform chondrichthyan braincase and the origin of chimaeroid fishes p.208

The chimaeroids are one of the four principal divisions of the living jawed vertebrates and their evolutionary origins have been hard to discern; here, the study of a skull of the extinct shark Dwykaselachus shows that the chimaeroids nest among the once fairly common and widespread symmoriiforms.

doi: 10.1038/nature20806


Genome sequence and genetic diversity of European ash trees OPEN p.212

The genome sequence and genetic diversity of European ash (Fraxinus excelsior) trees reveals the species’ varying susceptibility to ash dieback.

doi: 10.1038/nature20786


Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes p.217

Structural differences in 40- and 42-residue-long amyloid-β fibrils seeded in vitro from the cortical tissue of patients with different clinical subtypes of Alzheimer’s disease suggest that different fibril structures form in different disease variants and with different peptide lengths.

doi: 10.1038/nature20814


Hypoxia induces heart regeneration in adult mice p.222

A pathway triggered by chronic severe hypoxia boosts regeneration of injured hearts in adult mice.

doi: 10.1038/nature20173


mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide p.228

The polypeptide SPAR is encoded by a long non-coding RNA, localizes to the late endosome and lysosome, and regulates muscle regeneration by inhibiting mTORC1.

doi: 10.1038/nature21034

がん:ゲノム規模のin vivoスクリーニングから見つかった転移性コロニー形成の新たな宿主調節因子

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization p.233

Screening mutant mouse lines using a genome-wide in vivo assay identifies microenvironmental regulators of metastatic colonization and defines SPNS2 as an important mediator of lung colonization.

doi: 10.1038/nature20792

遺伝学:in situの空間配置と相関するDNA切断マッピングによって明らかになった可変的クロマチン構造

Variable chromatin structure revealed by in situ spatially correlated DNA cleavage mapping p.237

The first genome-wide map of human chromatin conformation at the 1–3 nucleosome (50–500 base pair) scale, obtained using ionizing radiation-induced spatially correlated cleavage of DNA with sequencing (RICC-seq), which identifies spatially proximal DNA–DNA contacts.

doi: 10.1038/nature20781


Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography p.242

Femtosecond XFEL crystallography is used to identify dynamic changes in the adenine riboswitch aptamer domain, with at least four states identified in real time, two in the apo form before binding and two with the ligand bound.

doi: 10.1038/nature20599

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