Volume 540 Number 7633


トランプ次期米国大統領が、科学を軽視し温暖化対策に反対するScott Pruittを環境保護庁(EPA)長官に指名したことには失望する。

Donald Trump’s choice for head of the US environment agency is dismaying p.315

Scott Pruitt has consistently opposed attempts to reduce pollution.

doi: 10.1038/540315b


Corporate culture spreads to Scandinavian institutes p.315

The trend of turning universities into businesses is limiting research freedoms in traditionally liberal institutes in northern Europe. It is time for scientists to regain lost ground.

doi: 10.1038/540315a


Sequence reveals genes behind bizarre sea-horse traits p.316

A Nature paper explores this unusual creature from the inside out.

doi: 10.1038/540316a



Tech giants open virtual worlds to bevy of AI programs p.323

Artificial-intelligence algorithms can learn a lot from playing immersive 3D video games.

doi: 10.1038/540323a


Italian scientists won’t miss departing Prime Minister Matteo Renzi p.324

Italy’s youngest leader failed to walk the talk when it came to boosting research, academics say.

doi: 10.1038/nature.2016.21139


Controversial impact factor gets a heavyweight rival p.325

Elsevier’s CiteScore uses a larger database — and provides different results for the quality of journals.

doi: 10.1038/nature.2016.21131


CRISPR heavyweights battle in US patent court p.326

The University of California, Berkeley, and the Broad Institute are vying for lucrative rights to the gene-editing system.

doi: 10.1038/nature.2016.21101


Does it matter if Donald Trump has a science adviser? p.327

His plans for the job are a mystery, but past presidents have used their chief scientific aide in a number of ways.

doi: 10.1038/nature.2016.21129


Algorithms compete to predict recipe for cancer vaccine p.328

How to rouse the immune system against tumours has proved elusive.

doi: 10.1038/540328a

News Features


Three minutes with Hans Rosling will change your mind about the world p.330

スウェーデン・カロリンスカ医科大学の医師で、非営利組織Gapminder Foundationの創設者でもあるHans Roslingは、世界の貧困の実状を、先入観を捨てて事実に基づいて見つめるよう人々に働きかけている。

doi: 10.1038/540330a

News & Views


Pharmacology: Inside-out receptor inhibition p.344


doi: 10.1038/nature20486


Chemical biology: A radical change in enzyme catalysis p.345


doi: 10.1038/540345a


Cancer: A gene-expression profile for leukaemia p.346


doi: 10.1038/nature20488


Hydrology: The dynamics of Earth's surface water p.348


doi: 10.1038/nature21100


Stem cells: Cause and consequence in aged-muscle decline p.349


doi: 10.1038/nature20485


Biomedicine: An eye on retinal recovery p.350


doi: 10.1038/nature20487



The seahorse genome and the evolution of its specialized morphology p.395

Here, the genome sequence of the tiger tail seahorse is reported and comparative genomic analyses with other ray-finned fishes are used to explore the genetic basis of the unique morphology and reproductive system of the seahorse.

doi: 10.1038/nature20595


Electric-field-stimulated protein mechanics p.400

A new method in which strong electric fields are applied to a protein crystal while collecting time-resolved X-ray diffraction patterns is able to follow the mechanical motions of all the constituent atoms, with implications for molecular biology and drug discovery.

doi: 10.1038/nature20571



Resolved images of a protostellar outflow driven by an extended disk wind p.406

Observations of the outflow associated with the TMC1A protostellar system reveal that the ‘disk wind’ model correctly explains how material is ejected from protostars.

doi: 10.1038/nature20600


Extensive degeneracy, Coulomb phase and magnetic monopoles in artificial square ice p.410

All of the characteristics of the square-ice model are observed in an artificial square-ice system in which the two sublattices of nanomagnets are slightly vertically separated.

doi: 10.1038/nature20155


Accessing non-natural reactivity by irradiating nicotinamide-dependent enzymes with light p.414

Photoexcitation of a catalytic enzyme’s co-factor is shown to change the reactivity of the enzyme, enabling it to carry out a non-natural enantioselective dehalogenation of lactone molecules.

doi: 10.1038/nature20569


High-resolution mapping of global surface water and its long-term changes p.418

A freely available dataset produced from three million Landsat satellite images reveals substantial changes in the distribution of global surface water over the past 32 years and their causes, from climate change to human actions.

doi: 10.1038/nature20584


Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism p.423

Gene expression analysis in brain tissue from individuals with and without autism spectrum disorder (ASD) suggests that the transcription factor SOX5 contributes to an ASD-associated reduction in transcriptional differences between brain areas and indicates that common transcriptomic changes occur in different forms of ASD.

doi: 10.1038/nature20612


Epigenetic stress responses induce muscle stem-cell ageing by Hoxa9 developmental signals p.428

Changes in active chromatin marks in old activated satellite cells lead to Hoxa9 activation, which induces the expression of developmental pathway genes with a known inhibitory effect on satellite cell function and muscle regeneration in aged mice.

doi: 10.1038/nature20603


A 17-gene stemness score for rapid determination of risk in acute leukaemia p.433

A rapid gene signature test (LSC17) that captures stem cell expression programs in acute myeloid leukaemia patients at diagnosis is associated with therapy response and survival, facilitating initial treatment stratification.

doi: 10.1038/nature20598


Zika virus infection damages the testes in mice p.438

Infection of male mice with Zika virus caused testicular and epididymal damage, reduction in sex hormone levels, destruction of germ and somatic cells in the testis, loss of mature sperm and reduction in fertility.

doi: 10.1038/nature20556


Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice p.443

Monoclonal Zika-virus-neutralizing human antibodies can protect against maternal–fetal transmission, infection and disease.

doi: 10.1038/nature20564


Receptor usage dictates HIV-1 restriction by human TRIM5α in dendritic cell subsets p.448

Human TRIM5α restricts HIV-1 infection of Langerhans cells through a Langerin-dependent autophagy pathway.

doi: 10.1038/nature20567


Structure of photosystem II and substrate binding at room temperature p.453

The structures of three intermediate states of photosystem II, which is crucial for photosynthesis, have been solved at room temperature, shedding new light on this process.

doi: 10.1038/nature20161


Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists p.458

The crystal structure of CCR2 chemokine receptor in a complex with two different antagonists—one orthosteric the other allosteric—which functionally cooperate to inhibit CCR2.

doi: 10.1038/nature20605


Intracellular allosteric antagonism of the CCR9 receptor p.462

The crystal structure of the CCR9 chemokine receptor in complex with vercirnon at 2.8 Å resolution.

doi: 10.1038/nature20606


Structure and regulation of the chromatin remodeller ISWI p.466

The crystal structures of ISWI, the catalytic subunit of several chromatin remodelling complexes, and its complex with a histone H4 peptide are reported.

doi: 10.1038/nature20590

「Journal home」に戻る