More accountability for big-data algorithms p.449

To avoid bias and improve transparency, algorithm designers must make data sources and profiles public.

doi: 10.1038/537449a

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Socio-economic inequality in science is on the rise p.450

Current trends indicate that research is starting to become a preserve of the privileged.

doi: 10.1038/537450a

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US clampdown on clinical-trial reporting is long overdue p.450

Reform to 2007 law brings visibility to negative trial results.

doi: 10.1038/537450b

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Geneticists attempt to heal rifts with Aboriginal communities p.457

After decades of rocky relations, they are working together to trace indigenous communities’ ancestry.

doi: 10.1038/537457a

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US sharpens surveillance of crippling solar storms p.458

Next-generation space-weather model will map the danger facing power grids.

doi: 10.1038/537458a

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Detailed map shows Milky Way is bigger than we thought p.459

First results from Gaia probe also seem to solve old controversy over Pleiades cluster.

doi: 10.1038/nature.2016.20591

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Titanic clash over CRISPR patents turns ugly p.460

Accusations of impropriety feature in escalating dispute.

doi: 10.1038/537460a

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Human skeleton found on famed Antikythera shipwreck p.462

Two-thousand-year-old bones could yield first DNA from an ancient shipwreck victim.

doi: 10.1038/537462a

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News Features


Science and inequality p.465


doi: 10.1038/537465a

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Is science only for the rich? p.466


doi: 10.1038/537466a

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Science’s 1%: How income inequality is getting worse in research p.471


doi: 10.1038/537471a

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News & Views


Alzheimer's disease: Structure of aggregates revealed p.492


doi: 10.1038/nature19470

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Acoustics: Motion controlled by sound p.493


doi: 10.1038/537493a

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Developmental biology: Panoramic views of the early epigenome p.494


doi: 10.1038/nature19468

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Exoplanets: Migration of giants p.496


doi: 10.1038/nature19430

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Immunology: Channelling potassium to fight cancer p.497


doi: 10.1038/nature19467

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Condensed-matter physics: Multitasking materials from atomic templates p.499


doi: 10.1038/537499a

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Geology: Evidence of life in Earth's oldest rocks p.500


doi: 10.1038/nature19429

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Perimortem fractures in Lucy suggest mortality from fall out of tall tree p.503

Careful study of the famous fossil ‘Lucy’, a hominin who died over 3 million years ago, suggests that she died as a result of multiple injuries sustained in a fall–probably out of a tall tree.

doi: 10.1038/nature19332

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High-throughput discovery of novel developmental phenotypes p.508

Identification and characterization, using a comprehensive embryonic phenotyping pipeline, of 410 lethal alleles during the generation of the first 1,751 of 5,000 unique gene knockouts produced by the International Mouse Phenotyping Consortium.

doi: 10.1038/nature19356

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A partially differentiated interior for (1) Ceres deduced from its gravity field and shape p.515

Gravity and shape measurements for Ceres obtained from the Dawn spacecraft mission show that it is in hydrostatic equilibrium with its inferred normalized mean moment of inertia of 0.37, suggesting that Ceres has a rocky chondritic core overlaid by a volatile-rich icy shell.

doi: 10.1038/nature18955

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Holograms for acoustics p.518

Holograms for sound waves, encoded in a 3D printed plate, are used to shape sound fields that can be used for the contactless manipulation of objects.

doi: 10.1038/nature19755

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Atomically engineered ferroic layers yield a room-temperature magnetoelectric multiferroic p.523

A single-phase multiferroic material is constructed, in which ferroelectricity and strong magnetic ordering are coupled near room temperature, enabling direct electric-field control of magnetism.

doi: 10.1038/nature19343

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Switching on electrocatalytic activity in solid oxide cells p.528

A new way of activating the electrodes in solid oxide cells involves applying an electrical potential to trigger the exsolution of metal catalysts to the electrode surface; the success of this technique raises the possibility of regenerating the electrodes during operation.

doi: 10.1038/nature19090

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Molecular-scale evidence of aerosol particle formation via sequential addition of HIO3 p.532

Field data from an iodine-rich, coastal environment point to the molecular steps involved in the formation of new aerosol particles from iodine vapours over coastal regions.

doi: 10.1038/nature19314

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Rapid emergence of life shown by discovery of 3,700-million-year-old microbial structures p.535

Stromatolite fossils formed around 3,700 million years ago in what is now Greenland predate the previous oldest fossil evidence for life on Earth by more than 200 million years.

doi: 10.1038/nature19355

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Ionic immune suppression within the tumour microenvironment limits T cell effector function p.539

Potassium ions released by necrotic cells in tumours impair T cell function by increasing the intracellular potassium concentration in vitro and in vivo.

doi: 10.1038/nature19364

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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition p.544

Accumulation of fumarate resulting from mutations in fumarate hydratase,which are associated with renal and other cancers, is shown to induce epithelial-to-mesenchymal transition—a process associated with cancer initiation.

doi: 10.1038/nature19353

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Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition p.548

Three papers in this issue of Nature use highly sensitive ChIP–seq assays to describe the dynamic patterns of histone modifications during early mouse embryogenesis, showing that oocytes have a distinctive epigenome and providing insights into how the maternal gene expression program transitions to the zygotic program.

doi: 10.1038/nature19360

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Allelic reprogramming of the histone modification H3K4me3 in early mammalian development p.553

Three papers in this issue of Nature use highly sensitive ChIP–seq assays to describe the dynamic patterns of histone modifications during early mouse embryogenesis, showing that oocytes have a distinctive epigenome and providing insights into how the maternal gene expression program transitions to the zygotic program.

doi: 10.1038/nature19361

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Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos p.558

Three papers in this issue of Nature use highly sensitive ChIP–seq assays to describe the dynamic patterns of histone modifications during early mouse embryogenesis, showing that oocytes have a distinctive epigenome and providing insights into how the maternal gene expression program transitions to the zygotic program.

doi: 10.1038/nature19362

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A blue-light photoreceptor mediates the feedback regulation of photosynthesis p.563

Algae rely on blue-light-sensitive phototropin to trigger induction of LHCRS3, allowing it to dissipate energy from excess light that would otherwise compromise the fitness of the organism.

doi: 10.1038/nature19358

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Structural basis of kainate subtype glutamate receptor desensitization p.567

The high-resolution cryo-electron microscopy structure of the kainate receptor GluK2 subtype in its desensitized state is reported, which reveals that desensitization is attained by establishing a ring-like structure in the ligand-binding domains.

doi: 10.1038/nature19352

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