研究ポートフォリオ分析は、研究の経済性を高めるだけでなく、より広範な目的の達成にも役立ちそうだ。
Portfolio boost p.265
People who fund or manage many research projects could do it better with mindful analysis.
doi: 10.1038/524265b
People who fund or manage many research projects could do it better with mindful analysis.
doi: 10.1038/524265b
From the oceans to the soil, technology is changing the part that amateurs can play in research. But this greater involvement raises concerns that must be addressed.
doi: 10.1038/524265a
Research minister says two chunks of money from the European Union can now be released.
doi: 10.1038/524273a
Fears about the virus helped forge deal to elevate existing facility to BSL-4 status.
doi: 10.1038/nature.2015.18179
Fields with more women found to be more welcoming.
doi: 10.1038/nature.2015.18187
Analysis could force climate scientists to revisit estimates of global cycle.
doi: 10.1038/524276a
Researchers strive to reproduce and understand landmark result.
doi: 10.1038/nature.2015.18191
Proposed alpine ski area lies within nature reserve, prompting fears of development in other conservation areas.
doi: 10.1038/nature.2015.18174
大麻は、さまざまな国や地域で規制が緩和されているが、その長期使用の影響など重要な疑問点については、まだあまり明らかになっていない。
doi: 10.1038/524280a
細胞内小器官のミトコンドリアは、損傷を受けた場合には単一のシグナル伝達カスケードの働きによって処理されると考えられていた。だが今回、複雑な分子間相互作用のネットワークによって廃棄作業が開始されることが、細胞を使った解析によって明らかになった。
doi: 10.1038/nature15199
デングウイルス血清型2に対するヒト抗体は、マウスを病気にかかりにくくすることが示されている。ウイルスに結合した抗体の構造から、この抗体が多様な形態のウイルスに結合してウイルスの細胞侵入を防止する仕組みが明らかになった。
doi: 10.1038/524295a
通常は得られにくいニッケル中間体を生じる光活性化触媒が報告されたことによって、困難な触媒反応を実現する可能性のある一般的戦略が得られた。
doi: 10.1038/nature15200
組織の酸素濃度の低下に応答するタンパク質である、2種類の低酸素誘導因子の結晶構造から、これらの機能について手掛かりが得られ、合理的な薬剤設計に適した部位が明らかになった。
doi: 10.1038/nature14641
ボルネオ島にあるキナバル山に生息する1800種類を超える生物のDNA塩基配列についての研究によって、山地に見られる高度で独特な生物多様性につながる進化的機序が明らかになった。
doi: 10.1038/nature14645
天の川銀河の中心部に存在するガス雲G2は、銀河中心のブラックホールに接近遭遇した際に吸い込まれずに生き残り、ブラックホールの活動における主要なフレアアップを引き起こせなかったことが分かった。このガス雲の性質を説明できる有力な理論が提案されている。
doi: 10.1038/524301a
This study describes the long-awaited crystal structures for hypoxia-inducible factor (HIF) heterodimers, including complexes bound to small molecules and DNA; the HIF–ARNT architecture is distinct from the bHLH-PAS-containing CLOCK–BMAL1 heterodimer, and HIF mutations linked to cancer can be mapped to important structural regions, with the structures providing future reference for small-molecule drug discovery efforts.
doi: 10.1038/nature14883
The PINK1 ubiquitin kinase is shown to recruit the two autophagy receptors NDP52 and OPTN to mitochondria to activate mitophagy directly, independently of the ubiquitin ligase parkin; once recruited to mitochondria, NDP52 and OPTN recruit autophagy initiation components, and parkin may amplify the phospho-ubiquitin signal generated by PINK1, resulting in robust autophagy induction.
doi: 10.1038/nature14893
X-ray crystallography and molecular dynamics simulations of the μ-opioid receptor reveal the conformational changes in the extracellular and intracellular domains of this G-protein-coupled receptor that are associated with its activation.
doi: 10.1038/nature14886
Gas-giant planets are widely thought to form from solid ‘cores’ of roughly ten Earth masses; simulations now show that such cores can be produced from ‘pebbles’ (centimetre-to-metre-sized objects) provided that the pebbles form sufficiently slowly, leading to the formation of one to four gas giants in agreement with the observed structure of the Solar System.
doi: 10.1038/nature14675
A position sensor is demonstrated that is capable of resolving the zero-point motion of a nanomechanical oscillator in the timescale of its thermal decoherence; it achieves an imprecision that is four orders of magnitude below that at the standard quantum limit and is used to feedback-cool the oscillator to a mean photon number of five.
doi: 10.1038/nature14672
Despite advances in carbon–carbon fragment couplings, the ability to forge carbon–oxygen bonds in a general fashion via nickel catalysis has been largely unsuccessful; here, visible-light-excited photoredox catalysts are shown to provide transient access to Ni(iii) species that readily participate in reductive elimination, leading to carbon–oxygen coupling.
doi: 10.1038/nature14875
A revised estimate of Chinese carbon emissions from fossil fuel burning and cement production is presented, based on updated energy consumption and clinker production data and two new sets of measured emission factors for Chinese coal.
doi: 10.1038/nature14677
Geochemical data from inclusions within diamonds from the Northwest Territories, Canada, indicate that saline fluids are parental to silicic and carbonatitic deep mantle melts, via fluid–rock interaction; a subducting plate under western North America is suggested to be the source of the fluids.
doi: 10.1038/nature14857
The Ediacaran macrofossil Fractofusus reveals a complex life history of multigenerational, stolon-like asexual reproduction, interspersed with dispersal of waterborne propagules.
doi: 10.1038/nature14646
Investigating the evolutionary origins of montane biodiversity by sampling the entire biota from a single mountain, Mount Kinabalu in Borneo, allows for a better understanding not only of the origins of endemism, but also of this biota’s forecasted response to environmental change.
doi: 10.1038/nature14949
Feedbacks between the dissociation and advection of myosin II result in self-organized behaviour of actomyosin networks that drives shape changes during tissue morphogenesis.
doi: 10.1038/nature14603
Zinc transporter ZIP12 expression is increased in many cell types in remodelled mammalian pulmonary arterioles in hypoxia-induced pulmonary hypertension.
doi: 10.1038/nature14620
The MiT/TFE family of transcription factors is found to coordinate constitutive activation of autophagy and lysosome biogenesis to drive the metabolic programming and malignant growth of pancreatic cancer.
doi: 10.1038/nature14587
Diatoms optimize their photosynthetic efficiency via extensive energetic exchanges between plastids and mitochondria.
doi: 10.1038/nature14599
This study provides insights into conformational changes that lead to phospho-ubiquitin-induced PARKIN activation and how PARKIN is recruited to phospho-ubiquitin chains on mitochondria; the crystal structure of PARKIN in complex with phospho-ubiquitin also indicates that the pocket within PARKIN where phospho-ubiquitin binds carries amino acid residues that are mutated in patients with autosomal-recessive juvenile Parkinsonism.
doi: 10.1038/nature14879
NMR spectroscopy reveals the conformational changes of the μ-opioid receptor that are associated with receptor activation, helping to explain why the allosteric coupling between the agonist-binding pocket and the cytoplasmic G-protein-coupling interface of this receptor is relatively weak.
doi: 10.1038/nature14680
