Volume 519 Number 7541



Fatal fallout p.5

The Ebola epidemic has had a dire effect on the health prospects of pregnant women.

doi: 10.1038/519005b

気候変動懐疑論者であるWillie Soonの資金的背景の調査は、政治的動機によるものであり、学問の自由を脅かす恐れがある。

Gone fishing p.5

An investigation into the funding sources of climate scientists who have testified to the US Congress makes demands that have the potential to infringe on academic freedom.

doi: 10.1038/519005a


Hues and cry p.6

A blue dress divided the Internet — and put the science of visual perception in the spotlight.

doi: 10.1038/519006a



Ebola’s mental-health wounds linger in Africa p.13

Health-care workers struggle to help people who have been traumatized by the epidemic.

doi: 10.1038/519013a


Robo-rescuers battle it out in disaster challenge p.14

Nimble bots to go head-to-head for $2-million DARPA prize.

doi: 10.1038/519014a


UN climate panel charts next steps p.15

IPCC prepares for new leadership and plans another assessment of climate science.

doi: 10.1038/519015a


World's deadliest volcanoes identified p.16

Indonesia's population most at risk from eruptions.

doi: 10.1038/519016a


Therapeutic cancer vaccine survives biotech bust p.17

Pharmaceutical company rescues landmark prostate-cancer treatment, Provenge.

doi: 10.1038/519017a


Slick idea proposed to stretch water supplies p.18

In drought-ridden US, water managers consider using a coating one molecule thick to reduce evaporation from reservoirs.

doi: 10.1038/519018a

News Features


Developing world: The minority minority p.20


doi: 10.1038/519020a


Maternal health: Ebola’s lasting legacy p.24


doi: 10.1038/519024a

News & Views


HIV: Tied down by its own receptor p.36


doi: 10.1038/nature14205


Materials science: Nanoscale locomotion without fuel p.37


doi: 10.1038/519037a


Neuroscience: A cellular basis for the munchies p.38


doi: 10.1038/nature14206


Molecular biology: Signals across domains of life p.40


doi: 10.1038/nature14202


Materials science: Gating mechanism under pressure p.41


doi: 10.1038/519041a


Catalysis: Dual catalysis at the flick of a switch p.42


doi: 10.1038/519042a



Hypothalamic POMC neurons promote cannabinoid-induced feeding p.45

Cannabinoid-induced feeding signals are shown to enhance pro-opiomelanocortin (POMC) neuronal activity in mice, causing an enhancement of β-endorphin release, which is crucial in causing this cannabinoid-induced response; these results uncover an overlooked role of hypothalamic POMC neurons in the promotion of feeding by cannabinoids.

doi: 10.1038/nature14260


A motor cortex circuit for motor planning and movement p.51

During movement preparation, motor cortical neuronal subpopulations that project to downstream motor areas are more selective for the direction of upcoming movement than those that project to other cortical targets, especially immediately before movement, emphasizing the need to interpret complex neuronal responses measured during behaviour in the context of hierarchically organized cortical circuits.

doi: 10.1038/nature14178


A gp130–Src–YAP module links inflammation to epithelial regeneration p.57

This study demonstrates the activation of a STAT3-independent healing pathway in response to mucosal injury which involves the co-receptor for IL-6 cytokines gp130 and downstream effectors Src, Yes, YAP and Notch.

doi: 10.1038/nature14228


宇宙物理学:惑星状星雲Henize 2-428の、双縮退しスーパー・チャンドラセカール状態を示すコア

The double-degenerate, super-Chandrasekhar nucleus of the planetary nebula Henize 2-428 p.63

The probable evolution of the planetary nebula Henize 2-428 is examined, from a close binary system in which both stars ejected their envelopes to the white dwarf stage with a short orbital period and combined mass above the Chandrasekhar limit, suggesting that the system should merge in about 700 million years and trigger a type Ia supernova.

doi: 10.1038/nature14124


State preservation by repetitive error detection in a superconducting quantum circuit p.66

A quantum error correction scheme is demonstrated in a system of superconducting qubits, and repeated quantum non-demolition measurements are used to track errors and reduce the failure rate; increasing the system size from five to nine qubits improves the failure rate further.

doi: 10.1038/nature14270


Liquid-based gating mechanism with tunable multiphase selectivity and antifouling behaviour p.70

A rapid, reversible, non-fouling gating mechanism is created by infusing a porous membrane with a capillary-stabilized liquid that reconfigures under pressure to form a liquid-lined pathway, enabling selective multiphase transport with rationally tunable differential response profiles for a variety of liquids and gases.

doi: 10.1038/nature14253

有機化学:有機触媒反応および光酸化還元触媒反応によるアリルsp3 C–H結合の直接アリール化

The direct arylation of allylic sp3 C–H bonds via organic and photoredox catalysis p.74

Photoredox and organic catalysis are combined to achieve broadly effective direct arylation of allylic carbon–hydrogen bonds under mild conditions; this carbon–carbon bond forming reaction readily accommodates a wide range of alkene and electron-deficient arene coupling partners.

doi: 10.1038/nature14255


Drought impact on forest carbon dynamics and fluxes in Amazonia p.78

Severe drought in a tropical forest ecosystem suppresses photosynthetic carbon uptake and plant maintenance respiration, but growth is maintained, suggesting that, overall, less carbon is available for tree tissue maintenance and defence, which may cause the subsequent observed increase in tree mortality.

doi: 10.1038/nature14213

古生物学:復元されたホモ・ハビリスのタイプ標本OH 7は初期ヒト属でかなり早い段階に種多様性が生じたことを示唆する

Reconstructed Homo habilis type OH 7 suggests deep-rooted species diversity in early Homo p.83

Virtually reconstructing the jaw of OH 7 reveals a remarkably primitive shape, suggesting that the Homo habilis lineage originated before 2.3 million years ago; marking deep-rooted species diversity in the genus Homo.

doi: 10.1038/nature14224


AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges p.87

The new entry inhibitor eCD4-Ig, consisting of the immunoadhesin form of CD4 (CD4-Ig) fused to a small CCR5-mimetic sulfopeptide, avidly binds two highly conserved sites of the HIV-1 Env protein; the inhibitor has high potency and breadth and can neutralize 100% of a diverse panel of neutralization-resistant HIV-1 viruses, and when delivered to macaques using an adeno-associated virus vector, it can provide effective long-term protection from multiple challenges with simian/human immunodeficiency virus.

doi: 10.1038/nature14264


Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome p.92

Emulsifying agents, which are common food additives in the human diet, induce low-grade inflammation and obesity/metabolic syndrome in mice, suggesting that further investigation into the potential impact of dietary emulsifiers on the gut microbiota and human heath are warranted.

doi: 10.1038/nature14232


Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity p.97

In Caenorhabditis elegant, reduced insulin/IGF-1 signalling can promote longevity through a program that is genetically distinct from the dauer developmental pathway, and requires SKN-1-dependent collagen remodelling that is a broadly essential feature of longevity assurance pathways.

doi: 10.1038/nature14021


Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation p.102

A large ex vivo screen of approved and investigational anti-cancer drugs in primary cells derived from CML and ALL patients identifies axitinib, a VEGFR inhibitor approved for the treatment of kidney cancer, as a potent inhibitor of BCR–ABL1(T315I) with unique binding interactions that overcome the gatekeeper resistance mutation, highlighting the potential of repurposing existing drugs for additional cancer types.

doi: 10.1038/nature14119


Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch p.106

The structural polymorphism of intrinsically disordered protein 4E-BP2 allows it to regulate translation initiation through post-translational modification-mediated folding, exemplifying a new and potentially general mechanism of biological regulation mediated by intrinsically disordered proteins.

doi: 10.1038/nature13999

分子生物学:構造化された真核生物のIRES RNAによる細菌での翻訳開始

Initiation of translation in bacteria by a structured eukaryotic IRES RNA p.110

A eukaryotic viral internal ribosome entry site (IRES) element is described that binds both bacterial and eukaryotic ribosomes and initiates translation in both, demonstrating that RNA structure-based initiation can occur in both these domains of life, although in bacteria the element uses a mechanism that differs from that in eukaryotes.

doi: 10.1038/nature14219


Structure of the F-actin––tropomyosin complex p.114

Electron cryomicroscopy reveals the three-dimensional structure of F-actin at a resolution of 3.7 Å in complex with tropomyosin at a resolution of 6.5 Å; the stabilizing interactions and the effects of disease-causing mutants are also investigated.

doi: 10.1038/nature14033

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