Research press release


Nature Immunology

Immune response to traumatic brain injury



Dorian McGavernたちは、マウスモデルを使ってmTBIに対する免疫細胞の応答を研究し、受傷後4日の間に、創傷部位中の死細胞を除去する免疫細胞が関わる一次的な炎症応答が起こることを明らかにした。続いて、二次的な創傷治癒応答が観察され、他の免疫細胞が創傷の外周に集まり、細胞内部に入って、新しい血管の成長を促進し、凝血塊を除去した。この二次応答は1~3週間続いた。また、一次炎症応答の段階で再度損傷が起こると、回復過程が阻害され、永続的な障害につながることも分かった。


The immune system acts in two waves to repair damage resulting from mild traumatic brain injury, suggests a mouse study published online this week in Nature Immunology.

Mild traumatic brain injury (mTBI) is the most common form of brain injury. Roughly 50% of patients who have suffered mTBI experience damage within the brain meninges, the membranes that cover the surface of the brain, yet little is known about how these injuries heal, and no clinically approved treatment currently exists.

Dorian McGavern and colleagues use a mouse model to study immune cell responses to mTBI and identify a primary inflammatory response involving immune cells that scavenge dead cells within the wound site within the first four days after injury. They then observe a secondary wound-healing response involving other immune cells that gather at the wound’s perimeter before working their way inward, to promote the growth of new blood vessels and clear clotted material. This phase lasts between one week and three weeks. They also find that re-injury during the primary inflammatory phase disrupts the recovery process and can lead to persistent damage.

The authors speculate that the failure to repair meningeal blood vessels by interrupting this two-step process (via re-injury) might account for the post-concussive syndrome that develops in approximately 15% of patients after mTBI.

doi: 10.1038/s41590-018-0086-2


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