A meeting between the Pope, patients and researchers acknowledges how the two sectors can help each other.
doi: 10.1038/nature.2017.21985
The nation needs to end the long-running battle between regulators, lawmakers and industry.
doi: 10.1038/nature.2017.21987
The Department of Energy needs to prioritize the clean-up of nuclear waste.
doi: 10.1038/545266a
Rural and struggling areas have benefited from funding that is now at risk.
doi: 10.1038/545273a
Researchers and manufacturers face possible jail time — or execution — for fraudulent submissions to nation's drug agency.
doi: 10.1038/nature.2017.21977
Famous bell-shaped pots associated with group of immigrants who may have displaced Neolithic farmers.
doi: 10.1038/545276a
Desperate farmers hope scientists can beat pathogen that is wrecking the US orange harvest.
doi: 10.1038/545277a
DNA sequences from 100-year-old tumour samples could bolster childhood cancer research.
doi: 10.1038/nature.2017.21975
木造建築物は、より安全に、より強く、より高く、進化し続けており、温暖化の抑制にも効果があるかもしれない。
doi: 10.1038/545280a
腫瘍細胞は、ニッチと呼ばれる腫瘍の増殖を支える微小環境の一部を形成する非分裂細胞を生み出すことがあることが、今回分かった。こうしたニッチ細胞は、腫瘍の増殖や発達を促進するタンパク質を分泌する。
doi: 10.1038/nature22494
量子物体の系は、物体間の相関によって特性を評価できる。今回、最も弱い相関でも精密に測定できる手法によって、量子系のモデルを検証できた。
doi: 10.1038/545293a
加齢や多くの疾患は、部分的には、分裂しなくなった損傷細胞の蓄積によって進行する。今回、FOXO4タンパク質の活性を阻害する薬剤を用いれば、マウスのこうした老化細胞を完全に除去できることが分かった。
doi: 10.1038/nature22493
1967年の古典的論文で、気候のモデル化の重要な進歩が報告され、二酸化炭素の地球温暖化効果の説得力のある定量化が可能になった。これが、今日の気候研究を支えるモデルの基盤となっている。
doi: 10.1038/545296a
人々の間の協調が関与する問題では、時々間違いを起こすロボットの参加者を入れることで成績が向上することが、今回分かった。この知見は、実世界の協調問題に影響を及ぼす。
doi: 10.1038/545297a
The authors use computational modelling and a set of chemically synthesized compounds to define the physicochemical properties required for small-molecule accumulation in Gram-negative bacteria.
doi: 10.1038/nature22308
Lipopolysaccharide derived from gut bacteria can accelerate the formation of cerebral cavernous malformations by activating TLR4 on endothelial cells, and polymorphisms that increase expression of the genes encoding TLR4 or its co-receptor CD14 are associated with higher CCM lesion burden in humans.
doi: 10.1038/nature22075
In response to nitrate, Ca2+-sensor protein kinases (CPKs) act as master regulators to coordinate downstream signalling responses that are essential for shoot growth and root establishment in Arabidopsis.
doi: 10.1038/nature22077
The identification of the positions and patterns of amino acids that form the selectivity determinants for the entire human G-protein and G-protein-coupled receptor signalling system.
doi: 10.1038/nature22070
Experimental measurements of higher-order correlation functions in many-body systems provide insight into a non-trivial quantum field theory and how it can be implemented in a cold-atom quantum simulation.
doi: 10.1038/nature22310
The cell flow and defects within the alignment pattern of cultured mouse neural progenitor cells are described.
doi: 10.1038/nature22321
Modelling of two modes of continental crust formation suggests that before plate tectonics began operating, the Archean early Earth’s tectonic regime was governed by intrusive magmatism.
doi: 10.1038/nature22042
Earthquake rupture experiments and mathematical modelling reveal the existence of a torquing mechanism of thrust fault ruptures near the free surface that causes them to dynamically unclamp, open and slip large distances.
doi: 10.1038/nature22045
The Drosophila rhodopsin Rh7 works with cryptochrome to mediate circadian light entrainment by pacemaker neurons.
doi: 10.1038/nature22325
A complete larval zebrafish brain is examined and its myelinated axons reconstructed using serial-section electron microscopy, revealing remarkable symmetry and providing a valuable resource.
doi: 10.1038/nature22356
Preventing netrin secretion from floor-plate cells at the midline does not disrupt axonal guidance; commissural axons develop normally and the data suggest that netrin may influence axons locally by promoting growth cone adhesion.
doi: 10.1038/nature22331
A subset of Kras and p53 mutant cancer cells acts as a Wnt-producing niche for another cancer cell subset, and porcupine inhibition disrupts Wnt secretion in this niche, thereby suppressing proliferative potential and leading to therapeutic benefit.
doi: 10.1038/nature22334
In a mouse model of small-cell lung cancer and in human tumours, activation of the Notch pathway can lead to a cell fate switch of neuroendocrine cells to less proliferative non-neuroendocrine cells, generating intratumoural heterogeneity.
doi: 10.1038/nature22323
Ubiquitination of the GβL subunit, a component of both mTORC1 and mTORC2, acts as a regulatory switching mechanism to balance levels of mTORC1 and mTORC2; the failure of this mechanism in some cancers leads to elevated mTORC2 formation and tumorigenesis.
doi: 10.1038/nature22344
A networked colour coordination game, with humans interacting with autonomous software bots, shows that bots acting with small levels of random noise and being placed centrally in the network improves not only human–bot interactions but also human–human interactions at distant nodes.
doi: 10.1038/nature22332
