Volume 519 Number 7543



A clean, green science machine p.261

As the world warms and technology improves, researchers and institutions should look at their carbon footprints and question whether they really need to travel to academic conferences.

doi: 10.1038/519261a


Hollow humour p.261

The public’s distorted attitude towards mental-health conditions hampers their treatment.

doi: 10.1038/519261b

Nature Podcast Audiofileの最新ファイルは、音楽がいかに科学の着想を刺激するかを示している。

Strike a chord p.262

The latest episode of the Nature Audiofile podcast looks at how music inspires science.

doi: 10.1038/519262a



Marijuana gears up for production high in US labs p.269

Researchers will score more-powerful varieties of the drug courtesy of the National Institute on Drug Abuse.

doi: 10.1038/519269a

口径30 mの次世代光学赤外線超大型望遠鏡TMT計画の予算が、カナダ政府の2015年の予算に組み込まれるかどうかに注目が。

Crunch time for Canada’s role in mega-telescope p.270

Astronomers ask federal government to honour promise for Thirty Meter Telescope.

doi: 10.1038/519270a


Ethics of embryo editing divides scientists p.272

Researchers disagree over whether making heritable changes to human genes crosses a line.

doi: 10.1038/519272a


Irish government under fire for turning its back on basic research p.273

Letter from scientists questions commercially driven funding decisions.

doi: 10.1038/519273a


Five Solar System sights NASA should visit p.274

US planetary scientists dream up voyages of discovery, from Venus mappers to asteroid tours.

doi: 10.1038/519274a

News Features


The myopia boom p.276


doi: 10.1038/519276a


Fisheries: Eyes on the ocean p.280

ブリティッシュ・コロンビア大学(カナダ)の海洋生物学者Daniel Paulyは、国際連合食糧農業機関(FAO)の漁獲高データに大きな抜け落ちがあると警鐘を鳴らしている。

doi: 10.1038/519280a

News & Views


Materials chemistry: Cooperative carbon capture p.294


doi: 10.1038/nature14212


Biogeochemistry: Signs of saturation in the tropical carbon sink p.295


doi: 10.1038/519295a


Neuroscience: Hot on the trail of temperature processing p.296


doi: 10.1038/nature14209


Renewable energy: Better luminescent solar panels in prospect p.298


doi: 10.1038/519298a


Neuroscience: Spotlight on deep-brain stimulation p.299


doi: 10.1038/519299a


Cancer immunotherapy: Dendritic-cell vaccines on the move p.300


doi: 10.1038/nature14211



Cooperative insertion of CO2 in diamine-appended metal-organic frameworks p.303

A cooperative insertion mechanism for CO2 adsorption is shown to generate highly efficient adsorbents for carbon capture applications.

doi: 10.1038/nature14327


The fine-scale genetic structure of the British population p.309

Extensive genetic analysis of over 2,000 individuals from different locations in Britain reveals striking fine-scale patterns of population structure; comparisons with similar genetic data from the European continent reveal the legacy of earlier population migrations and information about the ancestry of current populations in specific geographic regions.

doi: 10.1038/nature14230


Visualizing transient Watson–Crick-like mispairs in DNA and RNA duplexes p.315

dG•dT and rG•rU ‘wobble’ mispairs in DNA and RNA transiently form base pairs with Watson–Crick geometry via tautomerization and ionization with probabilities that correlate with misincorporation probabilities during replication and translation.

doi: 10.1038/nature14227


Crystal structure of the eukaryotic origin recognition complex p.321

The crystal structure of the heterohexameric origin recognition complex (ORC), essential for coordinating DNA replication onset in eukaryotes, is resolved at 3.5 Å resolution.

doi: 10.1038/nature14239



A dusty, normal galaxy in the epoch of reionization p.327

Far-infrared measurements of galaxies in the early Universe would reveal their detailed properties, but have been lacking for the more typical galaxies where most stars form; here an archetypal, early Universe star-forming galaxy is detected at far-infrared wavelengths, allowing its dust mass, total star-formation rate and dust-to-gas ratio to be calculated.

doi: 10.1038/nature14164

宇宙物理学:ガス流の降着に起因する可能性がある、NGC 5253内の極めて効率の高い星形成

Highly efficient star formation in NGC 5253 possibly from stream-fed accretion p.331

Detection of carbon monoxide in a molecular cloud in dwarf galaxy NGC 5253 reveals the highest star-formation efficiency yet seen, driven by an accreting streamer of gas.

doi: 10.1038/nature14218


Ligand-enabled meta-C–H activation using a transient mediator p.334

A combination of norbornene and pyridine-type ligand enables commonly used ortho-directing groups to direct meta-C–H activation with palladium catalysts.

doi: 10.1038/nature14214


Observational determination of surface radiative forcing by CO2 from 2000 to 2010 p.339

Empirical evidence for the effect of rising atmospheric carbon dioxide levels on Earth’s surface energy balance is presented: the increase in surface radiative forcing from 2000 to 2010 measured at two sites is directly attributable to the increase in atmospheric carbon dioxide over that decade and agrees with model results.

doi: 10.1038/nature14240


Long-term decline of the Amazon carbon sink p.344

The capacity of Amazonian forests to sequester carbon has weakened with potentially important implications for climate change.

doi: 10.1038/nature14283


Polyploidy can drive rapid adaptation in yeast p.349

In vitro evolution experiments on haploid, diploid, and tetraploid yeast strains show that adaptation is faster in tetraploids, providing direct quantitative evidence that in some environments polyploidy can accelerate evolutionary adaptation.

doi: 10.1038/nature14187


Thermosensory processing in the Drosophila brain p.353

The mechanisms of thermosensing in the Drosophila brain are elucidated by the identification of distinct classes of projection neurons which are excited either by external cooling or warming, or both; the neurons that are excited by warming participate in complex circuits that incorporate crossover inhibition from cool receptor neurons.

doi: 10.1038/nature14170


Temperature representation in the Drosophila brain p.358

This study identifies distinct classes of neurons in the fly brain, which respond to external cooling, warming, or both, and contribute to behavioural response; the results illustrate how higher brain centres extract a stimulus’ quality, intensity and timing from a simple temperature map at the periphery.

doi: 10.1038/nature14284


CetZ tubulin-like proteins control archaeal cell shape p.362

The structure and function of CetZ, a protein related to both tubulin and FtsZ (the bacterial homologue of tubulin) from the archaeon Haloferax volcano, is reported and its involvement in the control of cell shape uncovered; it appears that this family of proteins was involved in the control of cell shape long before the evolution of eukaryotes.

doi: 10.1038/nature13983


Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients p.366

A clinical trial in patients with glioblastoma shows increased immune and anti-tumour responses to dendritic cell vaccination after pre-conditioning the site of vaccination with tetanus toxoid (Td); similar results are also seen in mice in part due to the actions of the chemokine CCL3, and the findings may represent new ways to improve the efficacy of anti-cancer vaccines.

doi: 10.1038/nature14320


A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol p.370

A human tRNA synthetase connects resveratrol to stress signalling.

doi: 10.1038/nature14028

分子生物学:NAD captureSeqにより示された、一部の調節性RNAに対する細菌のキャップとしてのNAD

NAD captureSeq indicates NAD as a bacterial cap for a subset of regulatory RNAs p.374

A newly developed method, NAD captureSeq, has been used to show that bacteria cap the 5′-ends of some RNAs to protect against degradation, much as happens with eukaryotic messenger RNAs, although with a different modification: nicotinamide adenine dinucleotide.

doi: 10.1038/nature14020

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