Global reach

doi: 10.1038/490309b

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Life after death

doi: 10.1038/490309a

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Badger away

doi: 10.1038/490310a

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Stem-cell fraud hits febrile field

doi: 10.1038/490321a

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The exoplanet next door

doi: 10.1038/490323a

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Badger battle erupts in England

doi: 10.1038/490317a

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Nobel work boosts drug development

doi: 10.1038/490320a

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Drug firm to share raw trial data

doi: 10.1038/490322a

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Antarctic seas in the balance

doi: 10.1038/490324a

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Politics holds back animal engineers

doi: 10.1038/490318a

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News Features


Science on the move


doi: 10.1038/490326a

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Science mapped out


doi: 10.1038/490325a

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News & Views


Planetary science: Galvanized lunacy p.346


doi: 10.1038/490346a

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Cancer therapy: Tumours switch to resist p.347


doi: 10.1038/nature11489

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Structural biology: Bundles of insights into sugar transporters p.348


doi: 10.1038/490348a

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HIV: Design by trial p.350


doi: 10.1038/490350a

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Molecular biology: Choose your protein partners p.351


doi: 10.1038/490351a

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Ecology: The big picture of marsh loss p.352


doi: 10.1038/490352a

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The aged niche disrupts muscle stem cell quiescence p.355

The niche is a conserved regulator of stem cell quiescence and function. During ageing, stem cell function declines. To what extent and by what means age-related changes within the niche contribute to this phenomenon are unknown. Here we demonstrate that the aged muscle stem cell niche, the muscle fibre, expresses Fgf2 under homeostatic conditions, driving a subset of satellite cells to break quiescence and lose their self-renewing capacity. We show in mice that relatively dormant aged satellite cells robustly express sprouty 1 (Spry1), an inhibitor of fibroblast growth factor (FGF) signalling. Increasing FGF signalling in aged satellite cells under homeostatic conditions by removing Spry1 results in the loss of quiescence, satellite cell depletion and diminished regenerative capacity. Conversely, reducing niche-derived FGF activity through inhibition of Fgfr1 signalling or overexpression of Spry1 in satellite cells prevents their depletion. These experiments identify an age-dependent change in the stem cell niche that directly influences stem cell quiescence and function.

doi: 10.1038/nature11438

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Crystal structure of a bacterial homologue of glucose transporters GLUT1–4 p.361

Glucose transporters are essential for metabolism of glucose in cells of diverse organisms from microbes to humans, exemplified by the disease-related human proteins GLUT1, 2, 3 and 4. Despite rigorous efforts, the structural information for GLUT1–4 or their homologues remains largely unknown. Here we report three related crystal structures of XylE, an Escherichia coli homologue of GLUT1–4, in complex with d-xylose, d-glucose and 6-bromo-6-deoxy-d-glucose, at resolutions of 2.8, 2.9 and 2.6 Å, respectively. The structure consists of a typical major facilitator superfamily fold of 12 transmembrane segments and a unique intracellular four-helix domain. XylE was captured in an outward-facing, partly occluded conformation. Most of the important amino acids responsible for recognition of d-xylose or d-glucose are invariant in GLUT1–4, suggesting functional and mechanistic conservations. Structure-based modelling of GLUT1–4 allows mapping and interpretation of disease-related mutations. The structural and biochemical information reported here constitutes an important framework for mechanistic understanding of glucose transporters and sugar porters in general.

doi: 10.1038/nature11524

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Structure of AMP-PNP-bound vitamin B12 transporter BtuCD–F p.367

The ATP-binding cassette (ABC) transporter BtuCD mediates the uptake of vitamin B12 across the inner membrane of Escherichia coli. Previous structures have shown the conformations of apo states, but the transport mechanism has remained unclear. Here we report the 3.5 Å crystal structure of the transporter-binding protein complex BtuCD–BtuF (BtuCD–F) trapped in an β-γ-imidoadenosine 5′-phosphate (AMP-PNP)-bound intermediate state. Although the ABC domains (BtuD subunits) form the expected closed sandwich dimer, the membrane-spanning BtuC subunits adopt a new conformation, with the central translocation pathway sealed by a previously unrecognized cytoplasmic gate. A fully enclosed cavity is thus formed approximately halfway across the membrane. It is large enough to accommodate a vitamin B12 molecule, and radioligand trapping showed that liposome-reconstituted BtuCD–F indeed contains bound B12 in the presence of AMP-PNP. In combination with engineered disulphide crosslinking and functional assays, our data suggest an unexpected peristaltic transport mechanism that is distinct from those observed in other ABC transporters.

doi: 10.1038/nature11442

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Hard-X-ray emission lines from the decay of 44Ti in the remnant of supernova 1987A p.373

doi: 10.1038/nature11473

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Zinc isotopic evidence for the origin of the Moon p.376

doi: 10.1038/nature11507

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Circuit quantum electrodynamics with a spin qubit p.380

doi: 10.1038/nature11559

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Bonding and structure of a reconstructed (001) surface of SrTiO3 from TEM p.384

doi: 10.1038/nature11563

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Coastal eutrophication as a driver of salt marsh loss p.388

doi: 10.1038/nature11533

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Delayed build-up of Arctic ice sheets during 400,000-year minima in insolation variability p.393

doi: 10.1038/nature11493

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神経:in vivoでバレル皮質ニューロンの曲げ方向同調を決める非線型的な樹状突起情報処理

Nonlinear dendritic processing determines angular tuning of barrel cortex neurons in vivo p.397

doi: 10.1038/nature11451

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Severe stress switches CRF action in the nucleus accumbens from appetitive to aversive p.402

doi: 10.1038/nature11436

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Androgenetic haploid embryonic stem cells produce live transgenic mice p.407

doi: 10.1038/nature11435

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Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation p.412

doi: 10.1038/nature11538

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医学:HIV-1ワクチンはEnv V2に遺伝的特徴を持つウイルスに対してより高い効力を持つ

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2 p.417

doi: 10.1038/nature11519

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A FOXO3–IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses p.421

doi: 10.1038/nature11428

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Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes p.426

doi: 10.1038/nature11464

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Initiation of transcription-coupled repair characterized at single-molecule resolution p.431

doi: 10.1038/nature11430

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