Research press release


Nature Genetics

Genetics: Variant associated with protection against typhoid fever


今回、S J Dunstanたちは、原因菌に感染しても、腸チフスになる者とならない者がいる理由を探るため、ベトナムとネパールの原因菌感染者と非感染者の遺伝子構成を比較した。その結果、HLA-DRB1*04:05という遺伝子バリアントの腸チフスに対する防御作用が、同じHLA遺伝子の別のバリアントのほぼ5倍であることが分かった。この遺伝子バリアントが位置しているHLA領域は、免疫系の調節を行うタンパク質をコードする遺伝子群が存在する6番染色体上の場所である

A genetic variant associated with the risk of contracting typhoid fever is reported in a study published online this week at Nature Genetics. The results further our understanding of how the bacteria that cause typhoid fever interact with their human hosts.

Typhoid fever, also known as enteric fever, infects more than 26 million people each year, mostly in low-income countries. The disease is caused by particular strains of Salmonella and is usually contracted by eating or drinking food or water contaminated by feces. Without treatment, 10-25% of those who become sick will die.

In order to understand why some people who come in contact with the bacteria become sick, while others do not, Sarah Jane Dunstan and colleagues compared the genetic makeup of infected and uninfected people from populations in Vietnam and Nepal. They found one genetic variant, HLA-DRB1*04:05, that confers nearly fivefold greater protection from the disease than the alternative variant of the same gene. The variant is found in the HLA region, which is a cluster of genes on chromosome 6 that encode proteins responsible for regulating the immune system.

doi: 10.1038/ng.3143


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