Research press release


Nature Genetics

Reservoir ducks



今回、Ning Liたちは、北京に生息する雌のマガモのゲノム全体について塩基配列解読を行った。そして、マガモのゲノム塩基配列を他の鳥類と哺乳類を比較したところ、マガモが保有する免疫関連遺伝子の数が哺乳類よりも少なく、ニワトリとキンカチョウのゲノムでの観察結果と同じであることが判明した。次に、Liたちは、高病原性と低病原性の鳥インフルエンザH5N1ウイルスに感染したマガモの肺における遺伝子発現を比較することによって、鳥インフルエンザウイルスに応答して発現パターンが変化する遺伝子を同定した。また、鳥インフルエンザ感染に対するマガモの宿主免疫応答に関係すると考えられる要因、例えば、鳥類と哺乳類のβデフェンシン遺伝子ファミリーも同定した。

The genome sequence of the duck is reported this week in Nature Genetics. This work identifies potential genetic factors influencing the duck's response to avian influenza infection, and will facilitate further studies to understand the mechanism for the greater protection seen in this type of waterfowl.

The recent emergence of avian influenza subtype H5N1 has contributed to widespread influenza outbreaks in poultry, and the duck has been implicated as a reservoir species by which the virus has spread. The duck, a natural host of influenza A viruses (including H5N1), is known to often remain asymptomatic following influenza infection.

Ning Li and colleagues sequenced the whole genome of a female duck from Beijing. Comparisons to the genome sequences of other birds and mammals showed that the duck contains fewer immune-related genes than mammals, similar to observations in the chicken and zebra finch genomes. By comparing gene expression in the lungs of ducks infected with either highly or weakly pathogenic avian influenza H5N1 viruses, the authors identify genes whose expression patterns are altered in response to avian influenza viruses. They also identify factors that may be involved in duck host immune response to avian virus infection, including the avian and mammalian beta-defensin gene families.

doi: 10.1038/ng.2657


メールマガジンリストの「Nature 関連誌今週のハイライト」にチェックをいれていただきますと、毎週各ジャーナルからの最新の「注目のハイライト」をまとめて皆様にお届けいたします。