Research press release


Nature Genetics

Risk for hepatitis B in Asians

アジア人におけるB型肝炎ウイルスの持続感染リスクと関連する遺伝子多型が同定されたことを報告する研究論文が、Nature Genetics(電子版)に掲載される。慢性B型肝炎は、最も一般的な感染性肝疾患の1つで、B型肝炎ウイルス(HBV)が原因となっている。



Scientists have identified genetic variations associated with the risk of persistent infection of hepatitis B virus in Asian populations, according to a study online this week in Nature Genetics. Chronic hepatitis B is one of the most common infectious liver diseases caused by hepatitis B virus (HBV).

Yusuke Nakamura and colleagues carried out an association study in Asian populations, and identified a significant association between chronic hepatitis B infection and 11 genetic variations in a region of the genome that includes the HLA-DPA1 and HLA-DPB1 genes. These genes are structurally similar to genes that encode proteins critical for launching an effective immune response against HBV.

There are an estimated 400 million people chronically infected with HBV worldwide, and nearly 60% of liver cancers are related to chronic hepatitis B and liver cirrhosis. Since the clinical outcomes after the exposure to HBV are highly variable, identification of genetic and environmental factors that are related to progression of HBV-induced liver diseases is critically important.

doi: 10.1038/ng.348


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