Research press release





今回、Ali Brivanlouたちの研究グループは、マイクロプリントされた特製ディスク上でヒト胚性幹(ES)細胞を培養し、成長因子で処理したところ、ES細胞からオーガナイザー様組織の生成が誘導された。次に、この細胞群をニワトリ胚に移植したところ、その周囲にある細胞から細長い神経組織の形成が誘導され、オーガナイザー能力が実証された。Brivanlouたちは、ヒト幹細胞を用いてオーガナイザーの特性を示す組織を得ることによって、幹細胞の働きの理解をさらに進めるシステムを確立した。

The organizer, a long-theorized cluster of cells that helps organize and direct embryonic development, has been demonstrated to be present in human tissue for the first time, reports a paper published online this week in Nature. The study provides a new model for early embryonic development and suggests that the organizer is highly conserved across the animal kingdom.

In 1924, Hans Spemann and Hilde Mangold performed what has become arguably one of the most famous experiments in developmental biology. They grafted a tiny piece of tissue from one salamander embryo into another salamander embryo and showed that it induced the host cells to form a second embryo. They called the grafted region the organizer, because it could organize the host cells around it.

In the new study, Ali Brivanlou and colleagues grew human embryonic stem cells on special microprinted disks and treated them with growth factors, which induced them to form organizer-like tissue. This cluster of cells was then grafted into chicken embryos, where it induced the surrounding host cells to form elongated neural tissue, demonstrating its organizational capacity. By using human stem cells to obtain a tissue displaying organizer properties, the authors have established a system that should enable further understanding of the workings of these cells.

doi: 10.1038/s41586-018-0150-y

「Nature 関連誌注目のハイライト」は、ネイチャー広報部門が報道関係者向けに作成したリリースを翻訳したものです。より正確かつ詳細な情報が必要な場合には、必ず原著論文をご覧ください。

メールマガジンリストの「Nature 関連誌今週のハイライト」にチェックをいれていただきますと、毎週最新のNature 関連誌のハイライトを皆様にお届けいたします。