Research press release

代謝 : 運動が老齢マウスの筋肉を若返らせる

Nature Metabolism

Metabolism: Exercise rejuvenates muscle in old mice

マウスの自発的な運動が筋肉の修復を加速し、老化した筋肉幹細胞を回復させることを示した論文が、Nature Metabolism に掲載される。


今回、Thomas Randoたちは、若いマウスと老齢のマウスに、自由に回転する回し車を与えて、3週間自発的に使わせた。すると、老齢のマウスほど、筋肉の修復が加速され、MuSCの機能が改善されることが分かった。このMuSCの活性改善は、休眠状態の幹細胞のサイクリンD1(細胞周期の進行に必要なタンパク質)レベルが、若いときのレベルに回復することによる。サイクリンD1は、老化を促進するTGF-β–Smad3情報伝達経路を休眠状態のときに抑制し、最終的にMuSCの再生を促進する。このような変化は、若いマウスでは老齢マウスほど明確には起こらない。


Voluntary exercise accelerates muscle repair and restores old muscle stem cells in mice, according to an article published in Nature Metabolism.

With advanced age, muscle mass declines, and the ability to regenerate and repair muscle is impaired. The reason for this decline is likely to involve both a reduced number of muscle stem cells (MuSCs) and a diminishing regenerative capacity with age. Although previous research has studied how to preserve muscle mass with age through exercise, little is known about the benefits of exercise in preserving regenerative capacity.

Thomas Rando and colleagues provided young and old mice 3 weeks’ voluntary access to freely rotating running wheels. The authors found accelerated muscle repair and improved old MuSC function in the older animals. These improvements in MuSC activation were due to the restoration of Cyclin D1 (a protein required for cell-cycle progression) in dormant stem cells back to youthful levels. Cyclin D1 suppresses the pro-ageing TGF-β–Smad3 signalling pathway in the dormant state, ultimately accelerating MuSC regeneration. These changes were less pronounced in young mice.

This research suggests that a short-term, voluntary exercise regimen is a practicable intervention for rejuvenating old MuSCs, although further studied are needed to determine whether these findings translate to humans.

doi: 10.1038/s42255-020-0190-0


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