Research press release


Nature Metabolism

Keep organs cool for transplantation



今回、Mike Murphy、Kourosh Saeb-Parsyたちは、マウス、ブタ、ヒトの心臓について、温かい状態、あるいは低温で保存し、詳細な代謝解析を行った。すると、心臓を提供後に温かいままに保つと、代謝産物であるコハク酸の蓄積量が増え、このコハク酸は心臓に血管を再びつないだ後に、心臓の組織を損傷させることが分かった。コハク酸の蓄積を薬剤投与や心臓の冷却によって防ぐと、マウスの心臓移植後の経過は改善した。


Rapid cooling of animal and human donor hearts may decrease the accumulation of a chemical that damages the tissue after transplantation, according to a new study in Nature Metabolism. These findings may lead to improved solutions for the storage of the limited pool of donor organs worldwide.

Storage of donor hearts in cold preservation solution is common practice in transplantation medicine. However, the chemical changes that occur in donor hearts during organ retrieval and the exact benefits of cold organ storage are not well understood.

Mike Murphy, Kourosh Saeb-Parsy and colleagues performed a detailed metabolic analysis of mouse, pig and human hearts stored at warm or cold temperatures. The authors found that allowing organs to remain warm after donation increased accumulation of the metabolite succinate, which damages heart tissue after organs are reconnected to blood vessels. Preventing this accumulation by administering a drug or by cooling organs improved heart-transplantation outcomes in mice.

The authors conclude that this research may lead to the formulation of new drugs to inhibit the formation of succinate in organs and improve results after transplantation.

doi: 10.1038/s42255-019-0115-y


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