Research Abstract


Tissue-adhesive wirelessly powered optoelectronic device for metronomic photodynamic cancer therapy

2018年7月16日 Nature Biomedical Engineering 3 : 7 doi: 10.1038/s41551-018-0261-7



Kento Yamagishi, Izumi Kirino, Isao Takahashi, Hizuru Amano, Shinji Takeoka, Yuji Morimoto and Toshinori Fujie

Corresponding Author

守本 祐司

藤枝 俊宣

Metronomic (that is, low-dose and long-term) photodynamic therapy (mPDT) for treating internal lesions requires the stable fixation of optical devices to internal tissue surfaces to enable continuous, local light delivery. Surgical suturing—the standard choice for device fixation—can be unsuitable in the presence of surrounding major nerves and blood vessels, as well as for organs or tissues that are fragile, change their shape or actively move. Here, we show that an implantable and wirelessly powered mPDT device consisting of near-field-communication-based light-emitting-diode chips and bioadhesive and stretchable polydopamine-modified poly(dimethylsiloxane) nanosheets can be stably fixed onto the inner surface of animal tissue. When implanted subcutaneously in mice with intradermally transplanted tumours, the device led to significant antitumour effects by irradiating for 10 d at approximately 1,000-fold lower intensity than conventional PDT approaches. The mPDT device might facilitate treatment strategies for hard-to-detect microtumours and deeply located lesions that are hard to reach with standard phototherapy.