Research Abstract


Origin of subdiffusion of water molecules on cell membrane surfaces

2014年4月17日 Scientific Reports 4 : 4720 doi: 10.1038/srep04720


山本 詠士1, 秋元 琢磨1, 安井 正人2 & 泰岡 顕治1

  1. 慶應義塾大学 理工学部 機械工学科
  2. 慶應義塾大学 医学部 薬理学教室
Water molecules play an important role in providing unique environments for biological reactions on cell membranes. It is widely believed that water molecules form bridges that connect lipid molecules and stabilize cell membranes. Using all-atom molecular dynamics simulations, we show that translational and rotational diffusion of water molecules on lipid membrane surfaces exhibit subdiffusion and aging. Moreover, we provide evidence that both divergent mean trapping time (continuous-time random walk) and long-correlated noise (fractional Brownian motion) contribute to this subdiffusion. These results suggest that subdiffusion on cell membranes causes the water retardation, an enhancement of cell membrane stability, and a higher reaction efficiency.