Research press release


Nature Medicine

Cleaning up bad blood


D Ingberたちは、ヒト血液タンパク質(マンノース結合性レクチン)に遺伝子操作を加えて作ったタンパク質で被覆した磁性ナノビーズを体外循環させた血液に加えて、さまざまな病原体や毒素を捕捉する装置を開発した。ビーズに結合した病原体や毒素を磁石により取り除いた後に、浄化された血液がラットの体内に戻されたが、血液の組成には目立った変化はなく、凝固も起こらなかった。


An external blood-cleansing device that mimics the spleen by rapidly and continuously removing pathogens and toxins from blood is described in a study published in Nature Medicine this week. The device, tested in rats, may lead to future potential treatments for human blood infections and septic shock, which leads to death in 30-50% of cases.

Don Ingber and colleagues developed a device, which uses magnetic nanobeads, coated with a genetically engineered version of a natural human blood protein (mannose-binding lectin), to capture a broad range of pathogens and toxins. Testing in rats, the authors showed that bead-bound pathogens and toxins could be pulled out of the flowing blood by a magnet. The cleansed blood was then be returned to the rat body without significantly altering its composition or causing coagulation.

The authors also demonstrated reduced levels of certain pro-inflammatory immune system cytokines known to play a role in the sepsis cascade and the removal of toxins that are key in a rat model of acute septic shock.

doi: 10.1038/nm.3640


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